Pathology Image Detail

Caption

Type A spindle cell adrenocortical carcinoma. The cortex of the adrenal gland was effaced by spindle shaped cells (blue cells) that compressed and separated the normal cortical cells (pink)

Description

Type A spindle cell adrenocortical carcinoma

Age at Necropsy

389 days

Contributor

Mikaelian I (J:94310)

Pathologist

Mikaelian I (J:94310)

Method

H&E

Model

MMHC ID
MTB:18397
Tumor Name
Adrenal gland - Cortex • carcinoma
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
adrenocortical carcinoma
Organ Affected
Adrenal gland - Cortex
Frequency
observed
Reference
J:94310

Strain

Strain
C.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Homozygous mice. These mice have been fully backcrossed onto BALB/cJ. The original mutation was generated using 129S2/SvPas ES cells and was crossed to C57BL/6 before being backcrossed to BALB/cJ.
Strain Synonyms
BALB/cJ-Trp53tm1Tyj
C.129S2(B6)-Trp53tm1Tyj
C.129S2-Trp53tm1Tyj/J
p53&delta
BALB-p53?/?
p53-/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
389 days