Pathology Image Detail

Caption

 Type A spindle cell adrenocortical carcinoma. The neoplasm is located on the left and has caused edema and necrosis of many adrenal cortical cells on the right. This is evidenced by the many clear spaces between the cells (edema fluid lost in the tissue processing).

Description

 Type A spindle cell adrenocortical carcinoma

Age at Necropsy

 389 days

Contributor

 Mikaelian I (J:94310)

Pathologist

 Mikaelian I (J:94310)

Method

 H&E

Model
MMHC ID
MTB:18397
Tumor Name
Adrenal gland - Cortex • carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
adrenocortical carcinoma
Organ Affected
Adrenal gland - Cortex
Frequency
observed
Reference
J:94310

Strain
Strain
C.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Homozygous mice. These mice have been fully backcrossed onto BALB/cJ. The original mutation was generated using 129S2/SvPas ES cells and was crossed to C57BL/6 before being backcrossed to BALB/cJ.
Strain Synonyms
BALB/cJ-Trp53tm1Tyj
C.129S2(B6)-Trp53tm1Tyj
C.129S2-Trp53tm1Tyj/J
p53&delta
BALB-p53?/?
p53-/-
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
389 days