Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15845/.

Description

follicular center cell lymphoma

Notes

Follicular lymphoma, mesenteric lymph node and intestine (Peyer?s patches). The mesenteric lymph node and intestinal Peyer?s patches are enlarged. The normal structures cannot be seen. The tissues are infiltrated by neoplastic lymphoma cells in various degrees of differentiation. The same mixture of lymphoid cells in 951-spleen can be seen including centroblasts, cleaved centrocytes and small lymphocytes (centrocytes). Mitotic figures are seen. Large areas of tumor cell necrosis is seen. In one section, there is a mass of neutrophils forming an abscess. The lymphoma cells are CD45R+ and non-neoplastic infiltrating small lymphocytes are CD3+. No slide for CD3 and CD45R staining is presented, pattern is identical as shown for Case # 990000951-5 shown in pathology record 6649.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69102
Tumor Name
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell • lymphoma - follicular
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
FCC lymphoma (CBCC)
follicular center cell lymphoma (FCC)
Organ Affected
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129
Strain Types
other
General Note
Mice with a mixed C57BL/6 and 129 background.
Strain Synonyms
B6, 129
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified