Caption |
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15848. |
Description |
follicular center cell lymphoma |
Notes |
Follicular lymphoma, with focal histiocytic sarcoma, mesenteric lymph node. The normal structure of the node cannot be seen. The enlarged node is mostly composed of lymphoid tumor cells (centroblasts, centrocytes) and focally histiocytic tumor cells with multinucleated giant cells, with abundant eosinophilic cytoplasm. The lymphoid tumor cells are variable in size and shape. There are large blast cells with prominent nucleoli (centroblasts), medium sized lymphocytes with inconspicuous nucleoli, lymphocytes with cleaved (folded) nuclei, and small lymphocytes (centrocytes). The lymphoma cells are CD45R+ and non-neoplastic infiltrating small lymphocytes are CD3+. |
Contributor |
Ward JM (J:107304) |
Pathologist |
Ward JM (J:107304) |
Copyright |
This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute. |
Method |
H&E |