Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15848.

Description

follicular center cell lymphoma

Notes

Follicular lymphoma, with focal histiocytic sarcoma, mesenteric lymph node. The normal structure of the node cannot be seen. The enlarged node is mostly composed of lymphoid tumor cells (centroblasts, centrocytes) and focally histiocytic tumor cells with multinucleated giant cells, with abundant eosinophilic cytoplasm. The lymphoid tumor cells are variable in size and shape. There are large blast cells with prominent nucleoli (centroblasts), medium sized lymphocytes with inconspicuous nucleoli, lymphocytes with cleaved (folded) nuclei, and small lymphocytes (centrocytes). The lymphoma cells are CD45R+ and non-neoplastic infiltrating small lymphocytes are CD3+.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69105
Tumor Name
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell • lymphoma - follicular
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
FCC lymphoma (CBCC)
follicular center cell lymphoma (FCC)
Organ Affected
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129
Strain Types
other
General Note
Mice with a mixed C57BL/6 and 129 background.
Strain Synonyms
B6, 129
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified