Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15575.

Description

immunoblastic lymphoma

Notes

Immunoblastic lymphoma (diffuse large B-cell lymphoma), spleen. The spleen is infiltrated by a mixed population of lymphoid cells (immunoblastic, centroblastic) with nuclei of variable size and shape and with a moderate amount of eosinophilic cytoplasm. Nuclei vary from large and central, acentric along the nuclear membrane. Mitotic figures are common. Some plasmacytoid cells can be seen. Tumor cells were CD45R+ and infiltrating CD3+ cells were seen. Repoterd CD45R and CD3 staining patterns have no submitted images.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69112
Tumor Name
Leukocyte • lymphoma - immunoblastic
Treatment Type
None (spontaneous)
Tumor Synonyms
immunoblastic lymphoma
Organ Affected
Leukocyte
Frequency
observed
Reference
J:107304

Strain

Strain
NFS.V
Strain Types
congenic
General Note
NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci from AKR and C58 mice.
Strain Synonyms
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified