Caption |
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15578. |
Description |
Diffuse large B-cell lymphoma, centroblastic, spleen |
Notes |
Diffuse large B-cell lymphoma, centroblastic, spleen. There is a diffuse infiltration of lymphoma cells throughout the spleen. The tumor cells are uniform in size and shape with prominent central nucleoli and sparse cytoplasm. Many mitotic figures are observed. The starry sky effect is seen (tingible-body macrophages throughout containing tumor cell debris). Metastatic tumor cell foci are seen in the liver. The tumor cells are CD45R+. Some tumor infiltrating CD3+ lymphocytes are scattered in the spleen. |
Contributor |
Ward JM (J:107304) |
Pathologist |
Ward JM (J:107304) |
Copyright |
This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute. |
Method |
H&E |
