Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15905.

Description

splenic marginal zone lymphoma

Notes

Marginal zone lymphoma, spleen, advanced. The marginal zones and red pulp are infiltrated by a population of lymphoid cells with irregular to round nuclei with prominent nuclei and a moderate amount of eosinophilic cytoplasm. Small remnants of the white pulp can be seen. Foci of small basophilic cells (erythroid islands) are found throughout the red pulp. Metastases were not found in other tissues. Bouin?s fixation. From a Trp53 null mouse.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69592
Tumor Name
Leukocyte • lymphoma - splenic marginal zone
Treatment Type
None (spontaneous)
Tumor Synonyms
splenic marginal zone lymphoma
Organ Affected
Spleen
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129-Trp53tm1Brd
Strain Types
targeted mutation (knockout)
General Note
Homozygous mice. The genetic background of these mice was a mixture of C57BL/6 and 129 (substrain(s) not specified).
Strain Synonyms
p53 ko (B6, 129)
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified