Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15620.

Description

lymphoblastic lymphoma

Notes

Lymphoblastic lymphoma, T-cell, spleen and liver. There is diffuse infiltration of lymphoblasts into the splenic white and red pulp and liver. The neoplastic lymphoblasts have roundish nuclei with prominent nucleoli and sparse cytoplasm. Mitotic figures are numerous. The starry sky effect is seen composed of tangible-body macrophages. Lymphoma cells are CD3+. The lymphoma probably arose from the thymus and metastasized to these and other tissues.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69154
Tumor Name
Leukocyte - Lymphoblast • lymphoma - lymphoblastic
Treatment Type
None (spontaneous)
Tumor Synonyms
lymphoblastic lymphoma
Organ Affected
Leukocyte - Lymphoblast
Frequency
observed
Reference
J:107304

Strain

Strain
NFS.V
Strain Types
congenic
General Note
NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci from AKR and C58 mice.
Strain Synonyms
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified