Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15629/.

Description

histiocytic sarcoma

Notes

Histiocytic sarcoma, liver. There is massive infiltration in the liver by histiocytic tumor cells. The tumor cells form vascular thrombi and emboli, have oval shaped nuclei and have abundant pale eosinophilic cytoplasm. In a few foci, the tumor cells have a spindle shape. Some multinucleated giant tumor cells are seen. Tumor cells are CD68+ and F4/80+.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69156
Tumor Name
Leukocyte - Monocyte - Macrophage - Histiocyte • histiocytic sarcoma
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
histiocytic sarcoma
Organ Affected
Leukocyte - Monocyte - Macrophage - Histiocyte
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129
Strain Types
other
General Note
Mice with a mixed C57BL/6 and 129 background.
Strain Synonyms
B6, 129
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified