Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15899.

Description

follicular center cell lymphoma

Notes

Follicular lymphoma, spleen. There is a uniform enlargement of all white pulp areas. The white pulp has lost its normal structure. The white pulp is composed of a mixture of large blast cells (centroblasts), cleaved lymphoid cells (centrocytes with folded nuclei), and small lymphocytes (centrocytes). Some cells have abundant pale cytoplasm. The lymphoma cells are CD45R+ and non-neoplastic infiltrating small lymphocytes are CD3+.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.
Image Probes

Type: antibody

Name
anti-CD3 (SantaCruz)
Target
CD3
Supplier
Santa Cruz Biotechnology
Notes
Goat anti-human antibody.

Model

MMHC ID
MTB:69101
Tumor Name
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell • lymphoma - follicular
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
FCC lymphoma (CBCC)
follicular center cell lymphoma (FCC)
Organ Affected
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129
Strain Types
other
General Note
Mice with a mixed C57BL/6 and 129 background.
Strain Synonyms
B6, 129
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified