Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15902.

Description

follicular center cell lymphoma

Notes

Follicular lymphoma, pancreatic-duodenal lymph node. The normal lymph node structures cannot be seen. There is a diffuse infiltration by a mixture of neoplastic lymphoid cells including blast cells (centroblasts), lymphocytes with cleaved (folded) nuclei (centrocytes) and small mature lymphocytes (centrocytes). Some immature lymphoid cells have abundant pale eosinophilic cytoplasm. The tumor cells are CD45R+. Many non-neoplastic some small tumor infiltrating lymphocytes are CD3+.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.
Image Probes

Type: antibody

Name
anti-CD45R/B220 (RA3-6B2)
Target
CD45R/B220
Supplier
BD Biosciences

Model

MMHC ID
MTB:69109
Tumor Name
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell • lymphoma - follicular
Treatment Type
None (spontaneous)
Agents
Tumor Synonyms
FCC lymphoma (CBCC)
follicular center cell lymphoma (FCC)
Organ Affected
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell
Frequency
observed
Reference
J:107304

Strain

Strain
B6;129
Strain Types
other
General Note
Mice with a mixed C57BL/6 and 129 background.
Strain Synonyms
B6, 129
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified