Caption |
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for TDT. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15884. |
Description |
Lymphoblastic lymphoma, thymic T-cell origin and marginal zone lymphoma, spleen |
Notes |
Lymphoblastic lymphoma, thymic T-cell origin and marginal zone lymphoma, spleen. The thymic mass in the mediastinum and splenic red and white pulp (PALS) contain thymic T-cell lymphoma cells. The tumor cells have round nuclei and prominent nuclei and have metastasized to the PALS and red pulp of the spleen. The starry sky effect (tingible-body macrophages) can be seen in both tissues. There is invasion of cardiac muscle and in peribronchial and perivascular locations in the lung. The splenic marginal zone is expanded in size and contains a population of large marginal zone B-cells with a roundish nucleus and a small nucleolus and pale eosinophilic cytoplasm. This lesion is an early marginal zone lymphoma of splenic origin. The primary thymic lymphoma and metastatic tumor cells in spleen are CD3+ and Tdt+. Some of the marginal zone lymphoma cells are CD45R+ but CD3- and Tdt-. |
Contributor |
Ward JM (J:107304) |
Pathologist |
Ward JM (J:107304) |
Copyright |
This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute. |
