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Last Database Update
2017-09-17
MTB 3.0
 
Help Pathology Image Search Results  
Search Summary
Accession Id: J:107304
Sort By: Organ
Display Limit: No Limit
149 (of 149) pathology reports displayed, including 779 images.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69172 Erythrocyte   leukemia - erythroleukemia Erythrocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed erythroid leukemia J:107304
5761
Image ID:
5761
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125418&XPos=4369393&YPos=1770975&ZPos=0&Lens=0.5524553571428571&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69112 Leukocyte   lymphoma - immunoblastic Leukocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed immunoblastic lymphoma J:107304
5747
Image ID:
5747
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125404&XPos=5064562&YPos=3613992&ZPos=0&Lens=0.870085685483871&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69147 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed splenic marginal zone lymphoma J:107304
5753
Image ID:
5753
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125420&XPos=9436639&YPos=1219804&ZPos=0&Lens=0.279796511627907&SignIn=Sign in as Guest.
5778
Image ID:
5778
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125395&XPos=7551997&YPos=368021&ZPos=0&Lens=0.2596672661870504&SignIn=Sign in as Guest.
5777
Image ID:
5777
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125425&XPos=7337768&YPos=-277918&ZPos=0&Lens=0.27835796915167094&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69151 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed Marginal zone lymphoma, spleen, with metastases J:107304
5835
Image ID:
5835
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125431&XPos=10716741&YPos=370207&ZPos=0&Lens=0.2827186684073107&SignIn=Sign%20in%20as%20Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69592 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous) B6;129-Trp53tm1Brd
Unspecified
reproductive status not specified
observed splenic marginal zone lymphoma J:107304
5754
Image ID:
5754
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125409&XPos=9808360&YPos=4383468&ZPos=0&Lens=0.4640456989247312&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69154 Leukocyte - Lymphoblast   lymphoma - lymphoblastic Leukocyte - Lymphoblast None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed lymphoblastic lymphoma J:107304
5755
Image ID:
5755
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125390&XPos=11279248&YPos=981895&ZPos=0&Lens=0.2734375&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69121 Leukocyte - Lymphocyte - B-lymphocyte   lymphoma - Burkitt Leukocyte - Lymphocyte - B-lymphocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed Diffuse large B-cell lymphoma, centroblastic, spleen J:107304
5774
Image ID:
5774
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125379&XPos=8035705&YPos=-3235916&ZPos=0&Lens=0.4401676829268293&SignIn=Sign in as Guest.
5748
Image ID:
5748
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125382&XPos=6772542&YPos=-182183&ZPos=0&Lens=0.42463235294117646&SignIn=Sign in as Guest.
5773
Image ID:
5773
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125405&XPos=6900528&YPos=1468178&ZPos=0&Lens=0.42463235294117646&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69143 Leukocyte - Lymphocyte - B-lymphocyte   lymphoma - lymphoblastic Leukocyte - Lymphocyte - B-lymphocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed B-cell lymphoblastic lymphoma J:107304
5776
Image ID:
5776
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125397&XPos=8226595&YPos=-1294148&ZPos=0&Lens=0.6083216292134831&SignIn=Sign in as Guest.
5751
Image ID:
5751
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125387&XPos=6589013&YPos=3990073&ZPos=0&Lens=0.4117157794676806&SignIn=Sign in as Guest.
5775
Image ID:
5775
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125426&XPos=7597753&YPos=878973&ZPos=0&Lens=0.4607712765957447&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69100 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Spleen None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5765
Image ID:
5765
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125427&XPos=16912347&YPos=-886328&ZPos=0&Lens=0.9498355263157895&SignIn=Sign in as Guest.
5740
Image ID:
5740
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125422&XPos=9753841&YPos=4690729&ZPos=0&Lens=1.03125&SignIn=Sign in as Guest.
5764
Image ID:
5764
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125429&XPos=5125425&YPos=2535679&ZPos=0&Lens=0.751953125&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69101 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5767
Image ID:
5767
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125433&XPos=5264536&YPos=396305&ZPos=0&Lens=0.26410060975609756&SignIn=Sign in as Guest.
5741
Image ID:
5741
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125385&XPos=8869950&YPos=-115319&ZPos=0&Lens=0.27622767857142855&SignIn=Sign in as Guest.
5766
Image ID:
5766
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125389&XPos=12111527&YPos=18029&ZPos=0&Lens=0.25240384615384615&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69102 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5742
Image ID:
5742
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125375&XPos=10122907&YPos=1100955&ZPos=0&Lens=0.27693414322250637&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69103 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5768
Image ID:
5768
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125412&XPos=16408980&YPos=601518&ZPos=0&Lens=0.29504427792915533&SignIn=Sign in as Guest.
5744
Image ID:
5744
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125424&XPos=7353160&YPos=1137853&ZPos=0&Lens=0.29994806094182824&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69105 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5770
Image ID:
5770
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125414&XPos=8102876&YPos=64720&ZPos=0&Lens=0.3515625&SignIn=Sign in as Guest.
5743
Image ID:
5743
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125402&XPos=10186314&YPos=-1787995&ZPos=0&Lens=0.32322761194029853&SignIn=Sign in as Guest.
5769
Image ID:
5769
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125411&XPos=7293642&YPos=2414645&ZPos=0&Lens=0.322265625&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69109 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed follicular center cell lymphoma J:107304
5771
Image ID:
5771
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125406&XPos=9434380&YPos=2909248&ZPos=0&Lens=0.508362676056338&SignIn=Sign in as Guest.
5772
Image ID:
5772
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125399&XPos=11590301&YPos=1530712&ZPos=0&Lens=0.508362676056338&SignIn=Sign in as Guest.
5745
Image ID:
5745
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125376&XPos=4618838&YPos=-1459142&ZPos=0&Lens=0.4833984375&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:71233 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Spleen None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed follicular lymphoma, spleen J:107304
5834
Image ID:
5834
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125381&XPos=8732261&YPos=-2908366&ZPos=0&Lens=0.370826198630137&SignIn=Sign%20in%20as%20Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69111 Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell   lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed plasma cell lymphoma J:107304
5746
Image ID:
5746
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125421&XPos=5509338&YPos=3807091&ZPos=0&Lens=0.6896894904458599&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69593 Leukocyte - Lymphocyte - Pre-T-lymphocyte   lymphoma - lymphoblastic Thymus None (spontaneous) B6;129-Trp53tm1Brd
Unspecified
reproductive status not specified
observed lymphoblastic lymphoma, thymic origin, early J:107304
5756
Image ID:
5756
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125403&XPos=3990415&YPos=895195&ZPos=0&Lens=0.6049231843575419&SignIn=Sign in as Guest.
5781
Image ID:
5781
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125415&XPos=18241509&YPos=452242&ZPos=0&Lens=0.513181279620853&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69594 Leukocyte - Lymphocyte - Pre-T-lymphocyte   lymphoma - mixed Thymus None (spontaneous) B6;129-Trp53tm1Brd
Unspecified
reproductive status not specified
observed Lymphoblastic lymphoma, thymic T-cell origin and marginal zone lymphoma, spleen J:107304
5790
Image ID:
5790
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for TDT. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125438&XPos=7793161&YPos=376595&ZPos=0&Lens=0.3504247572815534&SignIn=Sign in as Guest.
5788
Image ID:
5788
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125440&XPos=8365956&YPos=-253921&ZPos=0&Lens=0.3405070754716981&SignIn=Sign in as Guest.
5789
Image ID:
5789
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125443&XPos=8519789&YPos=-1046447&ZPos=0&Lens=0.3609375&SignIn=Sign in as Guest.
5762
Image ID:
5762
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125439&XPos=3795468&YPos=1385597&ZPos=0&Lens=0.34484474522292996&SignIn=Sign in as Guest


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69155 Leukocyte - Lymphocyte - T-lymphocyte   lymphoma - lymphoblastic Thymus Chemical/Drug
dimethylbenzanthracene (DMBA)
B6;129
Unspecified
reproductive status not specified
observed thymic origin lymphoblastic lymphoma J:107304
5757
Image ID:
5757
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125417&XPos=9696164&YPos=-665439&ZPos=0&Lens=0.2667025862068966&SignIn=Sign in as Guest.
5782
Image ID:
5782
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125401&XPos=13361430&YPos=2336686&ZPos=0&Lens=0.3291223404255319&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69130 Leukocyte - Monocyte - Macrophage - Histiocyte   lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed histiocyte-rich lymphoma J:107304
5749
Image ID:
5749
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125448&XPos=7926165&YPos=1129364&ZPos=0&Lens=0.3102614613180516&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69138 Leukocyte - Monocyte - Macrophage - Histiocyte   lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous) NFS.V
Unspecified
reproductive status not specified
observed histiocyte-rich lymphoma J:107304
5750
Image ID:
5750
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125449&XPos=4941101&YPos=-60139&ZPos=0&Lens=0.6810141509433962&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69156 Leukocyte - Monocyte - Macrophage - Histiocyte   histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous) B6;129
Unspecified
reproductive status not specified
observed histiocytic sarcoma J:107304
5758
Image ID:
5758
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125394&XPos=9238764&YPos=-513137&ZPos=0&Lens=0.29265202702702703&SignIn=Sign in as Guest.
5783
Image ID:
5783
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD68. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125400&XPos=10261181&YPos=-1260990&ZPos=0&Lens=0.3067457507082153&SignIn=Sign in as Guest.
5784
Image ID:
5784
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for F4/80. A whole-slide scan of this image can be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125419&XPos=10891277&YPos=1906298&ZPos=0&Lens=0.322265625&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:69158 Leukocyte - Myelocyte (Granulocyte)   leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) None (spontaneous) CFW
Unspecified
reproductive status not specified
observed Myeloid leukemia, undifferentiated, without maturation, spleen J:107304
5760
Image ID:
5760
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125377&XPos=9194597&YPos=260981&ZPos=0&Lens=0.26154891304347827&SignIn=Sign in as Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:71024 Leukocyte - Myelocyte (Granulocyte)   leukemia - myelocytic Spleen None (spontaneous) FVB/N-Tg(PML-RARA)556Kog
Unspecified
reproductive status not specified
observed Myeloid leukemia, preleukemic, spleen J:107304
5832
Image ID:
5832
Source of Image:
Ward JM
Pathologist:
Ward JM
Method / Stain:
H&E
Image Caption:
Image was submitted by Jerrald Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. Whole-slide scan of this image is available at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125432&XPos=6646230&YPos=2525131&ZPos=0&Lens=0.3550204918032787&SignIn=Sign%20in%20as%20Guest.
5833
Image ID:
5833
Source of Image:
Ward JM
Pathologist:
Ward JM
Image Caption:
Image was submitted by Jerrald Ward. This slide was stained for INOS. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. Whole-slide scan of this image is available at https://ndp.jax.org/NDPServe.dll?ViewItem?ItemID=125383&XPos=11495442&YPos=27611&ZPos=0&Lens=0.4944349315068493&SignIn=Sign%20in%20as%20Guest.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:28197 Mammary gland   adenocarcinoma Mammary gland None (spontaneous) B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Female
reproductive status not specified
observed 120 days Adenocarcinoma, glandular, circumscribed, mammary gland J:94320
1395
Image ID:
1395
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Circumscribed adenocarcinoma: the mammary parenchyma is effaced by a nodular, expensile, unencapsulated, densely cellular, polycystic mass. This mass is composed of glands that show various degrees of ectasia, contain an amorphous acidophilic material, and are lined by a one cell-thick cuboidal to columnar epithelium supported by a scant amount of fibrovascular stroma.
1396
Image ID:
1396
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Circumscribed adenocarcinoma: the mammary parenchyma is effaced by a nodular, expensile, unencapsulated, densely cellular, polycystic mass. This mass is composed of glands that show various degrees of ectasia, contain an amorphous acidophilic material, and are lined by a one cell-thick cuboidal to columnar epithelium supported by a scant amount of fibrovascular stroma. Neoplastic cells multifocally pile-up in a disorderly fashion. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate to large amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, hypochromatic, and with a large basophilic nucleolus. Mitoses are numerous.
1394
Image ID:
1394
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is markedly expanded and its' architecture is distorted by numerous hyperplastic and neoplastic nodules. Some neoplasms are expensile while some are invasive.
1393
Image ID:
1393
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there is, in the same field, a solid mammary adenocarcinoma (upper right corner of the field) with an invasive growth pattern, and a small circumscribed adenocarcinoma (lower left corner of the field) separated by areas of atypical hyperplasia and in situ carcinoma.
1397
Image ID:
1397
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Circumscribed adenocarcinoma: neoplastic cells multifocally pile-up in a disorderly fashion. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate to large amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, hypochromatic, and with a large basophilic nucleolus. Mitoses are numerous(arrowheads).


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29169 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous) FVB/N-Tg(Igf2)1aDdp
Female
reproductive status not specified
observed unknown Adenocarcinoma, papillary, mammary gland J:94320
1418
Image ID:
1418
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic.
1422
Image ID:
1422
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary mammary adenocarcinoma: this photomicrograph illustrates a peripheral portion of the neoplasm. The neoplasm is continuous with the epithelium of an interlobular mammary duct (D).
1414
Image ID:
1414
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: multiple nodular, densely cellular, unencapsulated, locally invasive, well-delineated neoplasms almost entirely replace the mammary gland.
1417
Image ID:
1417
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Large areas of liquefactive necrosis (*) are present at the center of the tumor.
1415
Image ID:
1415
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1421
Image ID:
1421
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph illustrates the central portions of the neoplasm. At the center of the neoplasm, the extracellular space between neoplastic papillae was often packed with macrophages (*), the cytoplasm of which was foamy.
1420
Image ID:
1420
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1416
Image ID:
1416
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Large areas of liquefactive necrosis (*) are present at the center of the tumor.
1419
Image ID:
1419
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29170 Mammary gland   adenocarcinoma in situ Mammary gland None (spontaneous) FVB/N-Tg(Igf2)1aDdp
Female
reproductive status not specified
observed unknown In situ papillary adenocarcinoma, mammary gland J:94320
1424
Image ID:
1424
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a few ducts and alveoli contain small papillary projections lined by a one cell-thick attenuated to cuboidal epithelium. Mitoses (arrowhead) are detected in the epithelium lining these papillae. Most of the epithelium lining acini and ducts is atrophic, except in a few areas (arrow) where cells have large nuclei.
1423
Image ID:
1423
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: all alveoli and ducts are moderately ectatic and contain various proportions of inspissated proteins, a proteinaceous fluid, and lipid droplets. In addition, a few ducts and alveoli contain small papillary projections lined by a one cell-thick attenuated to cuboidal epithelium.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29171 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous) FVB/N-Tg(Igf2)1bDdp
Female
reproductive status not specified
observed unknown Adenocarcinoma, papillary and glandular, secretory, with prominent lymphocytic and plasmacytic inflammation, mammary gland J:94320
1431
Image ID:
1431
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is prominent. The papillae are separated by a large amount of amorphous acidophilic material that contains a small number of desquamated and degenerated neoplastic cells intermingled with a moderate number of macrophages with a foamy cytoplasm.
1426
Image ID:
1426
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: a very prominent lymphocytic and plasmacytic infiltration is present in the stroma of the neoplasm at its' periphery. The neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium.
1433
Image ID:
1433
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is less obvious and is intermingled with areas with a glandular pattern. Degenerated neoplastic cells and neutrophils are present between neoplastic papillae.
1428
Image ID:
1428
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: the neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium. Neoplastic cells have distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles. The nucleus is large, central, oval, hyperchromatic, and with a coarsely-clumped chromatin. Numerous neoplastic cells undergo single cell necrosis and mitotic rate is elevated. Macrophages with a foamy cytoplasm are present in between neoplastic papillae.
1434
Image ID:
1434
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is effaced by a multilobular, unencapsulated, densely cellular, neoplasm.
1432
Image ID:
1432
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is less obvious and is intermingled with areas with a glandular pattern.
1427
Image ID:
1427
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: a very prominent lymphocytic and plasmacytic infiltration is present in the stroma of the neoplasm at its' periphery. The neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium.
1425
Image ID:
1425
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is effaced by a multilobular, unencapsulated, densely cellular, neoplasm. Most of the neoplasm has a papillary pattern (P), while one neoplastic lobule has a glandular pattern (G).
1430
Image ID:
1430
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is prominent. The papillae are separated by a large amount of amorphous acidophilic material that contains a small number of desquamated and degenerated neoplastic cells intermingled with a few macrophages.
1429
Image ID:
1429
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: the lumen of some glands contains apoptotic bodies.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29172 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) FVB/N-Tg(Igf2)1bDdp
Female
reproductive status not specified
observed unknown Carcinoma in situ, papillary, mammary gland J:94320
1435
Image ID:
1435
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally expanded by a nodular, ill-defined, unencapsulated, moderately cellular mass. A more cellular area is present at the center of this mass.
1436
Image ID:
1436
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the cellular area in this carcinoma in situ is characterized by epithelial cells piling-up and forming small papillae in a structure that resembles an intralobular duct. This change is associated with mild to moderate interstitial fibrosis and lymphoplasmacytic inflammation. Most neoplastic cells contain lipid vacuoles which are larger and more numerous in the cells lining the dysplastic acini surrounding the most advanced lesions.
1438
Image ID:
1438
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this photomicrograp illustrates a portion of the neoplasm where neoplastic cells form discrete papillae that are located in a moderately dilated intralobular duct. Atypia in this area is mild.
1437
Image ID:
1437
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the cellular area in this carcinoma in situ is characterized by epithelial cells piling-up and forming small papillae in a structure that resembles an intralobular duct. This change is associated with mild to moderate interstitial fibrosis and lymphoplasmacytic inflammation. Most neoplastic cells contain lipid vacuoles which are larger and more numerous in the cells lining the dysplastic acini surrounding the most advanced lesions. A few minute areas of cornification (arroheads) are also present.
1439
Image ID:
1439
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this photomicrograp illustrates a portion of the neoplasm where neoplastic cells form discrete papillae that are located in a moderately dilated intralobular duct. Atypia in this area is mild.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29173 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) FVB/N-Tg(Igf2)1bDdp
Female
reproductive status not specified
observed unknown Carcinoma in situ (early stage), mammary gland J:94320
1440
Image ID:
1440
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Early stages of in situ mammary carcinoma: this photomicrograph represents the appearance of the mammary gland of this mouse model in the early stages of neoplastic transformation. There is prominent lobular hyperplasia with accumulation of inspissated proteinaceous material in many alveoli and intralobular ducts. Alveoli and intralobular ducts are lined by a prominent epithelium that confers a "crowded" appearance to these structures.
1441
Image ID:
1441
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Early stages of in situ mammary carcinoma: this photomicrograph represents the appearance of the mammary gland of this mouse model in the early stages of neoplastic transformation. There is prominent lobular hyperplasia with accumulation of inspissated proteinaceous material in many alveoli and intralobular ducts. Alveoli and intralobular ducts are lined by a prominent epithelium that confers a "crowded" appearance to these structures. Cells do not pile-up disorderly and there is no evidence of atypia. Apoptotic cells are numerous.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29174 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous) FVB/N-Tg(Igf2)2Ddp
Female
reproductive status not specified
observed unknown Adenocarcinoma, papillary, secretory, with squamous differentiation J:94320
1447
Image ID:
1447
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary mammary adenocarcinoma: neoplastic glands are cuboidal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm which occasionally contains large lipid vacuoles. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. Neoplastic glands are filled with an inspissated proteinaceous material and desquamated neoplastic cells.
1442
Image ID:
1442
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm.
1446
Image ID:
1446
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary mammary adenocarcinoma: neoplastic glands are cuboidal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm which occasionally contains large lipid vacuoles. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. Neoplastic glands are filled with an inspissated proteinaceous material and desquamated neoplastic cells.
1448
Image ID:
1448
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of transition between a portion of the neoplasm with a glandular pattern (on the left of the photomicrograph) and a portion of the neoplasm with squamous differentiation (on the right of the photomicrophotograph). Squamous differentiation is associated with the formation of nests of cells undergoing cornification (arrowheads) and production of squames (*).
1443
Image ID:
1443
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae.
1452
Image ID:
1452
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of nests of cornified cells and squames.
1444
Image ID:
1444
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae.
1451
Image ID:
1451
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of nests of cornified cells (arrowhead). Cells in this area have distinct cell borders. Cells at various degrees of cornification are also present in the lower portions of the photomicrograph.
1449
Image ID:
1449
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation with the formation of nests of cornified cells.
1445
Image ID:
1445
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae and fill neoplastic glands.
1450
Image ID:
1450
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of squames. Neutrophils infiltrate this portion of the neoplasm.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29175 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous) FVB/N-Tg(Igf2)2Ddp
Female
reproductive status not specified
observed unknown Adenocarcinoma, papillary, secretory, mammary gland J:94320
1454
Image ID:
1454
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, neoplasm that contains, in its' center, large areas composed of desquamated and degenerated neoplastic cells. The neoplasm is composed of thin branched papillae and a few glands supported by a small to moderate amount of fibrovascular stroma.
1459
Image ID:
1459
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm.
1460
Image ID:
1460
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm. There are many mitotic figures.
1453
Image ID:
1453
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, neoplasm that contains, in its' center, large areas composed of desquamated and degenerated neoplastic cells.
1455
Image ID:
1455
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1456
Image ID:
1456
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1458
Image ID:
1458
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm.
1457
Image ID:
1457
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of collagen-rich fibrovascular stroma. Neoplastic cells are cuboidal to low columnar, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few small vacuoles of lipids. The nucleus is basal to central, medium-sized, oval, and normochromatic. The luminal spaces are filled with degenerated neoplastic cells. The stroma is infiltrated by a moderate number of neutrophils, lymphocytes and plasma cells.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29176 Mammary gland   adenoma Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed 300 days Adenoma, glandular, mammary gland J:94320
1466
Image ID:
1466
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma: a few neoplastic cells are multinucleated (arrowhead). This feature is consistent with aneuploidy and is often observed in tumors with alterations of p53.
1465
Image ID:
1465
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of large nest that have numerous small secondary lumens lined by a one cell-thick cuboidal epithelium. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sixed and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild.
1462
Image ID:
1462
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens.
1464
Image ID:
1464
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens lined by a one cell-thick cuboidal epithelium. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sixed and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild.
1461
Image ID:
1461
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm.
1463
Image ID:
1463
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29177 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed 300 days Mammary gland - Macrocyst, with atypia J:94320
1468
Image ID:
1468
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium.
1469
Image ID:
1469
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium. The cells lining the cysts have distinct cell borders and a moderate to large amount of acidophilic cytoplasm that often contain lipid vacuoles of various sizes. The nucleus is randomly located in the cell, is large, oval, hyperchromatic, and with a coarsely clumped chromatin. Anisokaryosis and anisocytosis are prominent. A few mitoses are detected.
1467
Image ID:
1467
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29178 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Adenocarcinoma, papillary, arising in a macrocyst, mammary gland J:94320
1476
Image ID:
1476
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis and formation of small secondary lumens. Nuclear palissading is prominent at the periphery of this neoplastic lobule.
1474
Image ID:
1474
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis (*) and formation of small secondary lumens.
1473
Image ID:
1473
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: neoplastic epithelial structures generally are several cells-thick (up to 10 cells-thick) and are characterized by the formation of secondary lumens. Neoplastic cells are large, cuboidal to polygonal, with distinct cell borders and a large amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sized, normochromatic, with a coarsely-clumped chromatin and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild.
1470
Image ID:
1470
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern.
1475
Image ID:
1475
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis and formation of small secondary lumens.
1472
Image ID:
1472
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern. The epithelial structures generally are several cells-thick (up to 10 cells-thick) and are characterized by the formation of secondary lumens. Neoplastic cells are large, cuboidal to polygonal, with distinct cell borders and a large amount of strongly acidophilic cytoplasm. The nucleus is central, oval, and medium-sized.
1471
Image ID:
1471
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern. The morphology of this lesion is similar to that of macrocysts, except that the glandular and papillary areas located at the periphery of the cysts in this tumors are more cellular than in macrocysts.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29179 Mammary gland   hyperplasia - lobular Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Lobular hyperplasia with atypia, mammary gland J:94320
1479
Image ID:
1479
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent. There is also moderate interstitial lymphocytic and plasmacytic inflammation.
1478
Image ID:
1478
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent.
1480
Image ID:
1480
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent. There is also moderate interstitial lymphocytic and plasmacytic inflammation.
1477
Image ID:
1477
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29180 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Unspecified
reproductive status not specified
observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
1484
Image ID:
1484
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia. Acini are lined by a one cell-thick cuboidal epithelium with prominent small lipid vacuoles and proteinaceous droplets. There is no evidence of atypia. A few mitoses are present.
1481
Image ID:
1481
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: two small, non-compressive, expensile, densely cellular nodules are present in a lactating mammary gland.
1482
Image ID:
1482
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia.
1483
Image ID:
1483
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia. Acini are lined by a one cell-thick cuboidal epithelium with prominent small lipid vacuoles and proteinaceous droplets. There is no evidence of atypia.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29181 Mammary gland   adenoma Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Unspecified
reproductive status not specified
observed unknown Adenoma, glandular, secretory, mammary gland J:94320
1488
Image ID:
1488
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is often basal, round to oval, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
1485
Image ID:
1485
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands supported by a small amount of fibrovascular stroma. The adjacent mammary gland is lactational.
1487
Image ID:
1487
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is ofetn basal, round to oval, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild.
1486
Image ID:
1486
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The adjacent mammary gland is lactational.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29182 Mammary gland   hyperplasia Mammary gland None (spontaneous) FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
Unspecified
reproductive status not specified
observed unknown Hyperplasia and atypia, mammary gland J:94320
1490
Image ID:
1490
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. Many cells in this area are large and have a large hyperchromatic nucleus with a contoured nuclear membrane. These features are consistent with aneuploidy, a phenomenon that is commonly observed in tumors with altered expression of Trp53. There is also a mild interstitial lymphocytic inflammation.
1489
Image ID:
1489
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. Many cells in this area are large and have a large hyperchromatic nucleus with a contoured nuclear membrane. These features are consistent with aneuploidy, a phenomenon that is commonly observed in tumors with altered expression of Trp53.
1491
Image ID:
1491
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. A pentapolar mitosis is present.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29183 Mammary gland   adenoma Mammary gland None (spontaneous) FVB/N-Tg(MtTGFA)100Lmb
Female
reproductive status not specified
observed unknown Adenoma, glandular, secretory, with atypia, mammary gland J:94320
1496
Image ID:
1496
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: the neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes.
1502
Image ID:
1502
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm. One neoplastic cell has a very large nucleus (arrowhead) comparatively to the other neoplastic cells in this field.
1499
Image ID:
1499
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is surrounded by a capsule infiltrated by a small number of lymphocytes and plasma cells. Inflammation extends into the neoplasm which comprises a moderate amount of stroma. There is also moderate anisokaryosis.
1493
Image ID:
1493
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm.
1497
Image ID:
1497
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: the neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is often basal, round, and hyperchromatic. Anisokaryosis and anisocytosis are moderate. Mitoses are not found in this field.
1500
Image ID:
1500
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm.
1492
Image ID:
1492
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm.
1501
Image ID:
1501
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm.
1494
Image ID:
1494
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm. The neoplasm is composed of closely-packed glands supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid.
1495
Image ID:
1495
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes.
1498
Image ID:
1498
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is surrounded by a capsule infiltrated by a small number of lymphocytes and plasma cells. Inflammation extends into the neoplasm which comprises a moderate amount of stroma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29184 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous) FVB/N-Tg(MtTGFA)100Lmb
Female
reproductive status not specified
observed unknown Macrocyst, mammary gland J:94320
1506
Image ID:
1506
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1510
Image ID:
1510
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.
1503
Image ID:
1503
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is markedly expanded by a large nodule that resembles a mammary lobule that has been expanded by a considerable amount of proteinaceous fluid. The large central cysts are interpreted as intralobular ducts. The club-shaped glands that radiate from the central cysts are interpreted as mammary acini.
1507
Image ID:
1507
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1509
Image ID:
1509
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.
1505
Image ID:
1505
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1504
Image ID:
1504
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is markedly expanded by a large nodule that resembles a mammary lobule that has been expanded by a considerable amount of proteinaceous fluid. The large central cysts are interpreted as intralobular ducts. The club-shaped glands that radiate from the central cysts are interpreted as mammary acini.
1508
Image ID:
1508
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. Neoplasms may arise within macrocysts.
1511
Image ID:
1511
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29185 Mammary gland   lesion Mammary gland None (spontaneous) FVB/N-Tg(MtTGFA)100Lmb
Female
reproductive status not specified
observed unknown Lactation responsive plaque, mammary gland J:94320
1514
Image ID:
1514
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia.
1516
Image ID:
1516
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia. A few mitoses are present.
1512
Image ID:
1512
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, well-defined, unencapsulated, densely cellular mass. The periphery of this mass is composed of closely-packed glands resembling mammary acini. The center of this mass is composed of duct-like structures embedded in a large amount of loose fibrovascular stroma. These features are consistent with a diagnosis of a "lactation responsive plaque", although this plaque is unusually large.
1515
Image ID:
1515
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Image Caption:
Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia.
1513
Image ID:
1513
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, well-defined, unencapsulated, densely cellular mass. The periphery of this mass is composed of closely-packed glands resembling mammary acini. The center of this mass is composed of duct-like structures embedded in a large amount of loose fibrovascular stroma. These features are consistent with a diagnosis of a "lactation responsive plaque", although this plaque is unusually large.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29186 Mammary gland   lesion Mammary gland None (spontaneous) FVB/N-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Lactation-responsive plaque, mammary gland J:94320
1520
Image ID:
1520
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Lactation-responsive plaque: there is no evidence of atypia. The interstitium shows mild to moderate diffuse edema, and is infiltrated by a small number of granulocytes, lymphocytes, plasma cells and macrophages.
1518
Image ID:
1518
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Lactation-responsive plaque: lactation responsive plaques are ill-defined to discoid unencapsulated masses composed of acini at the periphery, and ducts at the center. The stroma is more abundant and more edematous at the center at the plaque than at its' periphery. There is no evidence of atypia of the epithelium. Secretory activity is abundant in this case.
1519
Image ID:
1519
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Lactation-responsive plaque: lactation responsive plaques are ill-defined to discoid unencapsulated masses composed of acini at the periphery, and ducts at the center. The stroma is more abundant and more edematous at the center at the plaque than at its' periphery. There is no evidence of atypia of the epithelium. Secretory activity is abundant in this case.
1517
Image ID:
1517
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by numerous ill-defined to nodular masses characterized by a radiating arrangement of intralobular ducts and acini.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29187 Mammary gland   fibroadenoma Mammary gland None (spontaneous) FVB/N-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Fibroadenoma, mammary gland J:94320
1525
Image ID:
1525
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses (arrowhead) are detected. Myoepithelial differentiation (arrows) is present. The stroma is abundant, contains numerous myofibroblasts, a small number of inflammatory cells, and loosely arranged wavy and thin collagen fibers.
1526
Image ID:
1526
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma: this photomicrograph illustrates the branching pattern of neoplastic ducts.
1527
Image ID:
1527
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma: this photomicrograph illustrates a portion of the neoplasm where myoepithelial differentiation (arrowheads) is prominent.
1524
Image ID:
1524
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses (arrowhead) are detected. The stroma is abundant, contains numerous myofibroblasts, a small number of inflammatory cells, and loosely arranged wavy and thin collagen fibers.
1521
Image ID:
1521
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma.
1522
Image ID:
1522
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium.
1523
Image ID:
1523
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29188 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous) FVB/N-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Hyperlastic alveolar nodule, mammary gland J:94320
1529
Image ID:
1529
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. Interlobular ducts located in the nearby panniculus are normal.
1533
Image ID:
1533
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1536
Image ID:
1536
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins. The epithelium lining of these glands do not show atypia. There is a mild to moderate interstitial infiltration by lymphocytes, plasma cells, and pigment-ladden macrophages.
1534
Image ID:
1534
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins.
1531
Image ID:
1531
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1530
Image ID:
1530
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. A few pigment-ladden macrophages are scattered in the interstitium.
1528
Image ID:
1528
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. Interlobular ducts located in the nearby panniculus are normal.
1532
Image ID:
1532
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1535
Image ID:
1535
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29189 Mammary gland   adenoma - mixed Mammary gland None (spontaneous) FVB/N-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Adenoma, tubular and glandular, mammary gland J:94320
1540
Image ID:
1540
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, and medium-sized. Anisokaryosis and anisocytosis are mild. Tubules (*) have a "crowded" appearance and resemble intralobular ducts. The glands have morphologic features consistent with the epithelium of mammary acini. There is a mild interstitial infiltration by lymphocytes, plasma cells and macrophages.
1537
Image ID:
1537
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed tubules and glands supported by a scant amount of fibrovascular stroma.
1538
Image ID:
1538
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma.
1541
Image ID:
1541
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary adenoma: neoplastic cells form glands with morphologic features consistent with the gestational mammary gland.
1539
Image ID:
1539
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29190 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous) FVB/N-Tg(MMTV-Erbb2)NF1Mul
Female
reproductive status not specified
observed unknown Adenocarcinoma, solid, mammary gland J:94320
1547
Image ID:
1547
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.
1544
Image ID:
1544
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma.
1545
Image ID:
1545
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma. Neoplastic cells are medium-sized, polygonal, often with distinct cell borders, and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, medium-sized and slightly hyperchromatic. Anisokaryosis and anisocytosis are mild.
1542
Image ID:
1542
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with a few minute areas of liquefactive necrosis and cavitation.
1543
Image ID:
1543
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma.
1546
Image ID:
1546
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.
1548
Image ID:
1548
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29191 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) FVB/N-Tg(MMTV-Erbb2)NF1Mul
Female
reproductive status not specified
observed unknown Carcinoma in situ, mammary gland J:94320
1549
Image ID:
1549
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there was, at the periphery of the solid mammary carcinoma, a dilated interlobular duct that was lined by a 5-10 cells-thick epithelium that often formed small secondary lumens. Myoepithelial differentiation was not identified in this duct. This lesion may represent invasion of an interlobular duct by the solid carcinoma, or may indicate in situ carcinoma in an interlobular duct adjancent to a mammary carcinoma. The formation of a relatively large number of secondary lumens, a feature that was not detected in the solid carcinoma, supports a diagnosis of in situ carcinoma.
1550
Image ID:
1550
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there was, at the periphery of the solid mammary carcinoma, a dilated interlobular duct that was lined by a 5-10 cells-thick epithelium that often formed small secondary lumens. Myoepithelial differentiation was not identified in this duct. This lesion may represent invasion of an interlobular duct by the solid carcinoma, or may indicate in situ carcinoma in an interlobular duct adjancent to a mammary carcinoma. The formation of a relatively large number of secondary lumens, a feature that was not detected in the solid carcinoma, supports a diagnosis of in situ carcinoma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29192 Mammary gland   adenocarcinoma Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Adenocarcinoma, glandular, secretory, with prominent interstitial fibrosis, mammary gland J:94320
1557
Image ID:
1557
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular and secretory adenocarcinoma: myoepithelial differentiation (arrowheads) is often prominent.
1553
Image ID:
1553
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts. Neoplastic glands are lined by a two cells-thick epithelium: cells of the basal layer resemble myoepithelial cells of the mammary gland while cells of the luminal layer resemble luminal cells of the mammary gland. Neoplastic luminal cells often contain lipid vacuoles of various sizes.
1552
Image ID:
1552
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts.
1555
Image ID:
1555
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular and secretory adenocarcinoma: this photomicrograph illustrates the ratio between the stroma (approximately 60% of the surface of the section) and the neoplastic epithelial cells (approximately 40% if the surface of the section). Cells in the stroma are oat-shaped to spindloid and resemble myofibroblasts.
1554
Image ID:
1554
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts. Neoplastic glands are lined by a two cells-thick epithelium: cells of the basal layer resemble myoepithelial cells of the mammary gland while cells of the luminal layer resemble luminal cells of the mammary gland. Neoplastic luminal cells often contain lipid vacuoles of various sizes.
1551
Image ID:
1551
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular neoplasm (only a portion of the neoplasm is present on the slide).
1556
Image ID:
1556
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular and secretory adenocarcinoma: mitoses (arrowheads) are detected in myofibroblasts and neoplastic epithelial cells.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29193 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
1560
Image ID:
1560
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal one cell-thick epithelium supported by a scant amount of connective tissue. Cells lining the glands have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles and proteinaceous droplets. There is no evidence of atypia and cells do not pile-up.
1558
Image ID:
1558
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is moderately expanded by small nodules of various sizes. Most of these nodules are well-delineated, unencapsulated, and densely cellular. Some are encapsulated and slightly compress the adjacent tissues. There is mild to moderate interstitial fibrosis and moderate ductal and alveolar ectasia in the remaining portions of the mammary gland.
1561
Image ID:
1561
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal one cell-thick epithelium supported by a scant amount of connective tissue. Cells lining the glands have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles and proteinaceous droplets. There is no evidence of atypia and cells do not pile-up. A moderate number of epithelial cells undergo apoptosis.
1559
Image ID:
1559
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal epithelium.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29194 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Macrocyst, mammary gland J:94320
1567
Image ID:
1567
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: the cystic spaces are filled with an amorphous acidophilic material. Numerous small glands radiate from the smaller cysts.
1564
Image ID:
1564
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilocular mass. The cysts that make up most of this mass contain an inspissated proteinaceous material and are lined by a 2 cells-thick cuboidal epithelium that, in a few areas, forms secondary glands.
1565
Image ID:
1565
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: as exemplified on this photomicrograph, mitotic activity (arrowheads) is multifocally prominent. The cells lining the ducts and the cysts are cuboidal to low columnar, have indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus tends to be basal, is medium-sized, round to oval and normochromatic. Anisokaryosis and anisocytosis are mild. There is a moderate interstitial granulocytic (eosinophilic?) infiltration.
1562
Image ID:
1562
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilocular mass.
1566
Image ID:
1566
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: this low power magnification illustrates the cystic appearance of most macrocyts, and also the connection between the larger cyst and smaller cysts that radiate from the largest cyst. Small adenomas are present at the periphery of the macrocyst.
1563
Image ID:
1563
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilocular mass. The cysts that make up most of this mass contain an inspissated proteinaceous material and are lined by a 2 cells-thick cuboidal epithelium.
1569
Image ID:
1569
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocysts: the epithelium surrounding the major cyst is once cell-thick and is composed of attenuated cells. The epithelium lining the glands is cuboidal. There is no evidence of atypia. The proteinaceous material in the lumen of the glands often is inspissated. There is no evidence of atypia.
1568
Image ID:
1568
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Macrocyst: the cystic spaces are filled with an amorphous acidophilic material. Numerous small glands radiate from the smaller cysts. The cysts and the glands are lined by a 1-2 cells-thick epithelium supported by a small to moderate amount of fibrovascular stroma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29195 Mammary gland   adenoma Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Adenoma, glandular, secretory, mammary gland J:94320
1577
Image ID:
1577
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma.
1579
Image ID:
1579
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): mitoses (arrowheads) are numerous in some fields.
1574
Image ID:
1574
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. Similar smaller masses and hyperplastic alveolar nodules distort the remaining portions of the mammary gland.
1573
Image ID:
1573
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma (small): cells lining neoplastic glands are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains proteinaceous droplets (arrow) or small lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisocytosis and anisokaryosis are mild. A moderate number of mitoses (arrowheads) is present.
1578
Image ID:
1578
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma. Most glands are filled with an occasionally inspissated proteinaceous fluid. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains a few small lipid droplets. The nucleus generally is basal, round to oval, medium-sized, and normochromatic. Anisokaryosis and anisocytosis are mild.
1570
Image ID:
1570
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland, small glandular adenoma: the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. This mass is composed of small glands supported by a scant amount of fibrovascular stroma.
1571
Image ID:
1571
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland, small glandular adenoma: the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. This mass is composed of small glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma. Some glands are ectatic and are filled with an amorphous proteinaceous fluid.
1576
Image ID:
1576
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma.
1575
Image ID:
1575
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. Similar smaller masses and hyperplastic alveolar nodules distort the remaining portions of the mammary gland.
1580
Image ID:
1580
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary glandular adenoma (large): this photomicrograph illustrates the glandular pattern of this adenoma.
1572
Image ID:
1572
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Glandular adenoma, small glandular adenoma: cells lining neoplastic glands are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains small lipid vacuoles.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29196 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
1581
Image ID:
1581
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.
1582
Image ID:
1582
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.
1583
Image ID:
1583
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29197 Mammary gland   fibroadenoma Mammary gland None (spontaneous) FVB-Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed 300 days Fibroadenoma, secretory, with atypia, mammary gland J:94320
1590
Image ID:
1590
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia.
1587
Image ID:
1587
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid oaccasionally admixed with a coarse granular yellow-brown pigment.
1596
Image ID:
1596
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates portion of the neoplasm with a fibrous srtoma (to the left of the photomicrograph) and other portions of the neoplasm with a cellular stroma. Mitoses are not rare, even in the most immature portions of the neoplasm.
1594
Image ID:
1594
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma. Small clusters of cells seem to be engaged in the early stages of cornificatin (arrowhead).
1595
Image ID:
1595
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates portion of the neoplasm with a fibrous stroma (to the left of the photomicrograph) and other portions of the neoplasm with a cellular stroma.
1597
Image ID:
1597
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates the bi-stratified feature of the neoplasm. Arrowheads point at cells with myoepithelial differentiation.
1585
Image ID:
1585
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid.
1593
Image ID:
1593
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma. A few neoplastic cells are multinucleated (arrowhead).
1586
Image ID:
1586
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid.
1584
Image ID:
1584
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma.
1589
Image ID:
1589
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: the neoplasm is composed of dilated glands filled with a proteinaceous material and embedded in a large amount of dense fibrovascular stroma. There are two layers to the neoplastic epithelium: (1) a luminal layer composed of cuboidal cells that often contain lipid vacuoles and occasionally proteinaceous droplets; (2) an inconspicuous basal (=myoepithelial) layer. There is no evidence of atypia in this microscopic field.
1598
Image ID:
1598
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates the bi-stratified feature of the neoplasm. Cells with myoepithelial differentiation are difficult to differentiate from stromal cells, and are best identified with immunolabeling for myoepithelial cell markers (keratins 5, 14 and 17, alpha smooth muscle actin, p63, caldesmon, ...).
1588
Image ID:
1588
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid oaccasionally admixed with a coarse granular yellow-brown pigment.
1591
Image ID:
1591
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too.
1592
Image ID:
1592
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29198 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous) B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Female
reproductive status not specified
observed 120 days Adenocarcinoma, solid, comedo, mammary gland J:94320
1600
Image ID:
1600
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, invasive, densely cellular neoplasm. The neoplasm is composed of thick interconnected cords with prominent central liquefactive necrosis and supported by a small to moderate amount of fibrovascular stroma. Small secondary lumens are occasionally detected (arrowheads). Neoplastic cells are medium-sized, polygonal to spindloid, with indistinct cell borders and they have a moderate amount of strongly amphophilic cytoplasm.
1599
Image ID:
1599
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a nodular, invasive, densely cellular neoplasm. The neoplasm is composed of thick interconnected cords with prominent central liquefactive necrosis and supported by a small to moderate amount of fibrovascular stroma.
1601
Image ID:
1601
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Comedo mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where cells form 1-2 cells thick cords. It is often at the vicinity of these areas that epithelial to mesenchymal transition occurs.
1603
Image ID:
1603
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Comedo mammary adenocarcinoma: neoplastic cells are medium-size, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is medium-size, oval, hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Numerous neoplastic cells undergo single cell necrosis. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1602
Image ID:
1602
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Comedo mammary adenocarcinoma: this photomicrograph illustrates areas of the neoplasm that is predominantly solid with large central areas of liquefactive necrosis. In addition, neoplastic cells form a few lumens.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29199 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous) B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Female
reproductive status not specified
observed 120 days Adenocarcinoma, circumscribed, solid, comedo, glandular, mammary gland J:94320
1607
Image ID:
1607
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Comedo mammary adenocarcinoma: the neoplasm is composed of thick trabeculae and solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells occasionally form inconspicuous lumens (arrowhead). Neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central and oval.
1606
Image ID:
1606
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.
1608
Image ID:
1608
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Comedo mammary adenocarcinoma: the neoplasm is composed of thick trabeculae and solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic, with 1-2 large basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous neoplastic cells undergo single cell necrosis.
1605
Image ID:
1605
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.
1604
Image ID:
1604
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29200 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous) B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Female
reproductive status not specified
observed 120 days Adenocarcinoma, papillary, circumscribed, mammary gland J:94320
1610
Image ID:
1610
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a small, nodular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of coalescing papillae supported by a small amount of fibrovascular stroma and lined by a (predominantly) one cell-thick columnar epithelium. Neoplastic cells often pile-up disorderly or form small secondary lumens.
1611
Image ID:
1611
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Papillary adenocarcinoma: neoplastic cells are columnar to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic, and with 1-3 small to medium-sized strongly basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous degenerated neoplastic cells have desquamated.
1609
Image ID:
1609
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a small, nodular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of coalescing papillae supported by a small amount of fibrovascular stroma and lined by a (predominantly) one cell-thick columnar epithelium. Neoplastic cells often pile-up disorderly.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29201 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous) B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
Female
reproductive status not specified
observed 120 days Adenocarcinoma, solid, with secondary lumens and epithelial to mesenchymal transition J:94320
1617
Image ID:
1617
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: the secondary lumens are filled by a proteinaceous fluid. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, slightly hypochromatic, with a stippled chromatin and 1-2 medium-sized and strongly basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1614
Image ID:
1614
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules that are made up of solid areas with secondary lumens.
1620
Image ID:
1620
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: a neoplastic lobule with prominent secondary lumens has prominent central coagulation necrosis.
1616
Image ID:
1616
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: the largest solid areas have central liquefactive necrosis and have a comedo-type pattern (*). All solid areas contain secondary lumens filled by a proteinaceous fluid.
1619
Image ID:
1619
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with a a solid pattern and with numerous secondary lumens (*). Nearby neoplastic lobules have a more classical solid pattern with large central areas of liquefactive necrosis ("comedo" pattern).
1618
Image ID:
1618
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with a pattern intermediate between a glandular pattern and a solid pattern. Numerous secondary lumens (*) are present.
1622
Image ID:
1622
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid.
1615
Image ID:
1615
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: the largest solid areas have central liquefactive necrosis and have a comedo-type pattern. All solid areas contain secondary lumens filled by a proteinaceous fluid.
1621
Image ID:
1621
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: a neoplastic lobule with prominent secondary lumens has prominent central coagulation necrosis.
1612
Image ID:
1612
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules of various size that are made up of glands (predominantly) and solid areas. These lobules are separated by a small amount of fibrovascular stroma.
1624
Image ID:
1624
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid. Neoplastic spindloid cells are difficult to differentiate from stromal myofibroblasts. Individual spindloid neoplastic cells are present in the stroma.
1613
Image ID:
1613
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules that are made up of solid areas with secondary lumens.
1623
Image ID:
1623
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid. Neoplastic spindloid cells are difficult to differentiate from stromal myofibroblasts.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29202 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous) FVB.Cg-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
Female
reproductive status not specified
observed unknown Adenocarcinoma, solid, comedo, mammary gland J:94320
1630
Image ID:
1630
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma with comedo pattern: this photomicrograph illustrates a portion of the neoplasm with prominent necrosis and early cavitation at the center of the solid areas. The cavitated area contains degenerated neoplastic cells.
1625
Image ID:
1625
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis, which gives a pseudo-glandular pattern to the neoplasm when examined at low magnification.
1628
Image ID:
1628
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis. Necrosis and cavitation are present at the center of the largest trabeculae.
1626
Image ID:
1626
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis supported by a small amount of fibrovascular stroma.
1629
Image ID:
1629
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Solid mammary adenocarcinoma with comedo pattern: this photomicrograph illustrates a portion of the neoplasm with prominent necrosis and early cavitation at the center of the solid areas.
1627
Image ID:
1627
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29203 Mammary gland   adenocarcinoma Mammary gland None (spontaneous) B6;C-Tg(MMTV-RET)127Ina
Female
reproductive status not specified
observed unknown Adenocarcinoma, glandular, mammary gland J:94320
1631
Image ID:
1631
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.
1636
Image ID:
1636
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. There is a mild lymphocytic and granulocytic infiltrate at the periphery of the neoplasm.
1633
Image ID:
1633
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.
1634
Image ID:
1634
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli.
1635
Image ID:
1635
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli.
1632
Image ID:
1632
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29204 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) B6;C-Tg(MMTV-RET)127Ina
Female
reproductive status not specified
observed unknown Carcinoma in situ, mammary gland J:94320
1639
Image ID:
1639
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: there is prominent proliferation of cells in a mammary alveolus. Thin fibrovascular projections subdivide the alveolus. Proliferating cells are large, with indistinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of invasion. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation. Myoepithelial differentiation is not detected in this portion of the lesion.
1640
Image ID:
1640
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: there is moderate proliferation of epithelial cells of all alveoli and ducts with occlusion of the ductal and alveolar lumen. Myoepithelial differentiation (arrowheads) is present in this portion of the lesion.
1638
Image ID:
1638
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: there is prominent proliferation of cells in all mammary alveoli and intralobular ducts. These cells occasionally form solid areas that expand mammary alveoli and acini. Proliferating cells are large, with indistinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of invasion. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1637
Image ID:
1637
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: there is, at the vicinity of a large glandular carcinoma (*) a neoplastic lobules that shows prominent proliferation of its' cells. Cells in this lobule pile-up disorderly and distend a few alveoli (arrowhead). The architecture of the lobule is preserved. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29205 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) B6;C-Tg(MMTV-RET)127Ina
Female
reproductive status not specified
observed unknown Carcinoma in situ, mammary gland J:94320
1645
Image ID:
1645
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds.
1646
Image ID:
1646
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds. There is mild interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1644
Image ID:
1644
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds.
1642
Image ID:
1642
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: hypercellularity of mammary lobules is the result of proliferation of luminal cells of mammary alveoli and intralobular ducts. These cells pile-up and occlude the lumen of some alveoli. There is no evidence of local invasion.
1643
Image ID:
1643
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: hypercellularity of mammary lobules is the result of proliferation of luminal cells of mammary alveoli and intralobular ducts. These cells pile-up and occlude the lumen of some alveoli. The cells populating this lobule are very heterogeneous. About 30% of these cells have primitive features: they are oval, with a pale acidophilic cytoplasm and a medium-sized slightly hypochromatic nucleus. The other cells are more differentiated and have a cuboidal to low columnar shape, a more strongly acidophilic cytoplasm and a normochromatic nucleus. There is no evidence of atypia but a few mitoses (arrowheads) are detected. There is no evidence of local invasion. There is mild interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1641
Image ID:
1641
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there is marked diffuse hypercellularity of two adjacent mammary lobules.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29206 Mammary gland   adenocarcinoma Mammary gland None (spontaneous) B6;C-Tg(MMTV-RET)127Ina
Female
reproductive status not specified
observed unknown Adenocarcinoma, glandular, mammary gland J:94320
1647
Image ID:
1647
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1650
Image ID:
1650
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm.
1651
Image ID:
1651
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm.
1649
Image ID:
1649
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1648
Image ID:
1648
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1653
Image ID:
1653
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is basal, often oriented in the long axis of the cell, medium-sized,normochromatic, with a finely stippled chromatin and 1-2 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
1652
Image ID:
1652
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: the neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is basal, often oriented in the long axis of the cell, medium-sized,normochromatic, with a finely stippled chromatin and 1-2 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29207 Mammary gland   carcinoma in situ Mammary gland None (spontaneous) B6;C-Tg(MMTV-RET)127Ina
Female
reproductive status not specified
observed unknown Carcinoma in situ, mammary gland J:94320
1661
Image ID:
1661
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1655
Image ID:
1655
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. A small focus of cornification (arrowhead) is present.There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1656
Image ID:
1656
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis. Myoepithelial differentiation is prominent and appears as a continuous layer of cells with a nucleus oriented parallel to the basement membrane and a scant amount of cytoplasm.
1658
Image ID:
1658
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this represents an early stage of in situ mammary carcinoma: the architecture of the mamamry gland is preserved but mammary lobules are packed with epithelial cells and often lack a lumen. Numerous cells in the mammary gland are round, have a very pale cytoplasm with a ground glass appearance, and have a medium-sized hypochromatic nucleus. These features are consistent with the features of a primitive epithelial cell. There is mild to moderate interstitial lymphocytic and plasmacytic inflammation. Myoepithelial differentiation is still detected and myoepithelial cells appear as cells with an ellongated nucleus parallel to the basement membrane and a scant amount of cytoplasm.
1662
Image ID:
1662
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this low magnification photomicrograph represents portions of a mammary gland with areas of in situ mammary carcinoma (at the center of the photomicrographs) with multiple areas of atypical hyperplasia more at the periphery of the neoplasm. There is moderate intersitial fibrosis and lymphoplasmacytic inflammation that involves all mammary lobules.
1659
Image ID:
1659
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1654
Image ID:
1654
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely-packed epithelial cells that form solid areas and small glands with an inconspicuous lumen.
1657
Image ID:
1657
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this represents an early stage of in situ mammary carcinoma: the architecture of the mamamry gland is preserved but mammary lobules are packed with epithelial cells and often lack a lumen. Numerous cells in the mammary gland are round, have a very pale cytoplasm with a ground glass appearance, and have a medium-sized hypochromatic nucleus. These features are consistent with the features of a primitive epithelial cell. There is mild to moderate interstitial lymphocytic and plasmacytic inflammation.
1660
Image ID:
1660
Source of Image:
Ward JM
Pathologist:
Mikaelian I
Method / Stain:
H&E
Image Caption:
In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents
Strain Name
Strain Sex
Reproductive Status
Tumor
Frequency
Age at
Necropsy
Description Reference
MTB:29230 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous) FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr