Pathology Image Search Results

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Accession Id
J:107304
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150 (of 150) pathology reports displayed, including 781 images.
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69172 Erythrocyte   leukemia - erythroleukemia Erythrocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed erythroid leukemia J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15638.
5761
Image ID:5761
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69112 Leukocyte   lymphoma - immunoblastic Leukocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed immunoblastic lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15575.
5747
Image ID:5747
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69130 Leukocyte   lymphoma - histiocytic Leukocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed histiocyte-rich lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15587.
5749
Image ID:5749
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69138 Leukocyte   lymphoma - histiocytic Leukocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed histiocyte-rich lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15590.
5750
Image ID:5750
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69147 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed splenic marginal zone lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15608.
5777
Image ID:5777
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15611/.
5778
Image ID:5778
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15605.
5753
Image ID:5753
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69151 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed Marginal zone lymphoma, spleen, with metastases J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image can be viewed at https://images.jax.org/webclient/img_detail/15896.
5835
Image ID:5835
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69592 Leukocyte   lymphoma - splenic marginal zone Spleen None (spontaneous)
B6;129-Trp53tm1Brd
 Unspecified reproductive status not specified observed splenic marginal zone lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15905.
5754
Image ID:5754
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69154 Leukocyte - Lymphoblast   lymphoma - lymphoblastic Leukocyte - Lymphoblast None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed lymphoblastic lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15620.
5755
Image ID:5755
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69121 Leukocyte - Lymphocyte - B-lymphocyte   lymphoma - Burkitt Leukocyte - Lymphocyte - B-lymphocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed Diffuse large B-cell lymphoma, centroblastic, spleen J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15584.
5774
Image ID:5774
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15581.
5773
Image ID:5773
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15578.
5748
Image ID:5748
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69143 Leukocyte - Lymphocyte - B-lymphocyte   lymphoma - lymphoblastic Leukocyte - Lymphocyte - B-lymphocyte None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed B-cell lymphoblastic lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15593.
5751
Image ID:5751
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15596.
5775
Image ID:5775
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15599.
5776
Image ID:5776
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69100 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Spleen None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15548.
5765
Image ID:5765
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15545.
5764
Image ID:5764
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15893.
5740
Image ID:5740
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69101 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15890.
5766
Image ID:5766
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15899.
5767
Image ID:5767
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/16007/.
5741
Image ID:5741
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69102 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15845/.
5742
Image ID:5742
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69103 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15851.
5744
Image ID:5744
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15566.
5768
Image ID:5768
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69105 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15848.
5743
Image ID:5743
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15560
5769
Image ID:5769
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15563.
5770
Image ID:5770
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69109 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed follicular center cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15854/.
5745
Image ID:5745
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15908.
5772
Image ID:5772
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15902.
5771
Image ID:5771
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:71233 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell   lymphoma - follicular Spleen None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed follicular lymphoma, spleen J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15857/.
5834
Image ID:5834
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69111 Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell   lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell None (spontaneous)
NFS.V
 Unspecified reproductive status not specified observed plasma cell lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image can be viewed at https://images.jax.org/webclient/img_detail/15860/
5746
Image ID:5746
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69593 Leukocyte - Lymphocyte - Pre-T-lymphocyte   lymphoma - lymphoblastic Thymus None (spontaneous)
B6;129-Trp53tm1Brd
 Unspecified reproductive status not specified observed lymphoblastic lymphoma, thymic origin, early J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15863/.
5781
Image ID:5781
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15623.
5756
Image ID:5756
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69594 Leukocyte - Lymphocyte - Pre-T-lymphocyte   lymphoma - mixed Thymus None (spontaneous)
B6;129-Trp53tm1Brd
 Unspecified reproductive status not specified observed Lymphoblastic lymphoma, thymic T-cell origin and marginal zone lymphoma, spleen J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15878.
5788
Image ID:5788
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD45R. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15881.
5789
Image ID:5789
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15641.
5762
Image ID:5762
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for TDT. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15884.
5790
Image ID:5790
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69155 Leukocyte - Lymphocyte - T-lymphocyte   lymphoma - lymphoblastic Thymus Chemical/Drug dimethylbenzanthracene (DMBA)
B6;129
 Unspecified reproductive status not specified observed thymic origin lymphoblastic lymphoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15626/.
5757
Image ID:5757
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD3. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15866.
5782
Image ID:5782
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69156 Leukocyte - Monocyte - Macrophage - Histiocyte   histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte None (spontaneous)
B6;129
 Unspecified reproductive status not specified observed histiocytic sarcoma J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15629/.
5758
Image ID:5758
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for CD68. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15869/.
5783
Image ID:5783
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. This slide was immunostained for F4/80. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15872/.
5784
Image ID:5784
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69158 Leukocyte - Myelocyte (Granulocyte)   leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) None (spontaneous)
CFW
 Unspecified reproductive status not specified observed Myeloid leukemia, undifferentiated, without maturation, spleen J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15635.
5760
Image ID:5760
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:71024 Leukocyte - Myelocyte (Granulocyte)   leukemia - myelocytic Spleen None (spontaneous)
FVB/N-Tg(PML-RARA)556Kog
 Unspecified reproductive status not specified observed Myeloid leukemia, preleukemic, spleen J:107304
Image Caption:Image was submitted by Jerrald Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. Whole-slide scan of this image is available at https://images.jax.org/webclient/img_detail/15632.
5832
Image ID:5832
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
Image Caption:Image was submitted by Jerrald Ward. This slide was stained for INOS. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. Whole-slide scan of this image is available at https://images.jax.org/webclient/img_detail/15875.
5833
Image ID:5833
Source of Image:Ward JM
Pathologist:Ward JM
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:28197 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
 Female reproductive status not specified observed 120 days Adenocarcinoma, glandular, circumscribed, mammary gland J:94320
Image Caption:Mammary gland: there is, in the same field, a solid mammary adenocarcinoma (upper right corner of the field) with an invasive growth pattern, and a small circumscribed adenocarcinoma (lower left corner of the field) separated by areas of atypical hyperplasia and in situ carcinoma.
1393
Image ID:1393
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Circumscribed adenocarcinoma: neoplastic cells multifocally pile-up in a disorderly fashion. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate to large amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, hypochromatic, and with a large basophilic nucleolus. Mitoses are numerous(arrowheads).
1397
Image ID:1397
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Circumscribed adenocarcinoma: the mammary parenchyma is effaced by a nodular, expensile, unencapsulated, densely cellular, polycystic mass. This mass is composed of glands that show various degrees of ectasia, contain an amorphous acidophilic material, and are lined by a one cell-thick cuboidal to columnar epithelium supported by a scant amount of fibrovascular stroma.
1395
Image ID:1395
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Circumscribed adenocarcinoma: the mammary parenchyma is effaced by a nodular, expensile, unencapsulated, densely cellular, polycystic mass. This mass is composed of glands that show various degrees of ectasia, contain an amorphous acidophilic material, and are lined by a one cell-thick cuboidal to columnar epithelium supported by a scant amount of fibrovascular stroma. Neoplastic cells multifocally pile-up in a disorderly fashion. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate to large amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, hypochromatic, and with a large basophilic nucleolus. Mitoses are numerous.
1396
Image ID:1396
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly expanded and its' architecture is distorted by numerous hyperplastic and neoplastic nodules. Some neoplasms are expensile while some are invasive.
1394
Image ID:1394
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29169 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1aDdp
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, mammary gland J:94320
Image Caption:Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic.
1418
Image ID:1418
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1420
Image ID:1420
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Large areas of liquefactive necrosis (*) are present at the center of the tumor.
1416
Image ID:1416
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are columnar, with indistinct cell borders and a moderate of amphophilic cytoplasm. The nucleus is central, oval, oriented at right angle with the basement membrane, medium-sized, and hyperchromatic.
1419
Image ID:1419
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates the central portions of the neoplasm. At the center of the neoplasm, the extracellular space between neoplastic papillae was often packed with macrophages (*), the cytoplasm of which was foamy.
1421
Image ID:1421
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1415
Image ID:1415
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this neoplasm is nodular, unencapsulated, densely cellular, and locally invasive. It is composed of thin branched papillae and tubules lined by a one cell-thick columnar epithelium and supported by a small to moderate amount of fibrovascular stroma. Large areas of liquefactive necrosis (*) are present at the center of the tumor.
1417
Image ID:1417
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple nodular, densely cellular, unencapsulated, locally invasive, well-delineated neoplasms almost entirely replace the mammary gland.
1414
Image ID:1414
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: this photomicrograph illustrates a peripheral portion of the neoplasm. The neoplasm is continuous with the epithelium of an interlobular mammary duct (D).
1422
Image ID:1422
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29170 Mammary gland   adenocarcinoma in situ Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1aDdp
 Female reproductive status not specified observed unknown In situ papillary adenocarcinoma, mammary gland J:94320
Image Caption:Mammary gland: all alveoli and ducts are moderately ectatic and contain various proportions of inspissated proteins, a proteinaceous fluid, and lipid droplets. In addition, a few ducts and alveoli contain small papillary projections lined by a one cell-thick attenuated to cuboidal epithelium.
1423
Image ID:1423
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a few ducts and alveoli contain small papillary projections lined by a one cell-thick attenuated to cuboidal epithelium. Mitoses (arrowhead) are detected in the epithelium lining these papillae. Most of the epithelium lining acini and ducts is atrophic, except in a few areas (arrow) where cells have large nuclei.
1424
Image ID:1424
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29171 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1bDdp
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary and glandular, secretory, with prominent lymphocytic and plasmacytic inflammation, mammary gland J:94320
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is less obvious and is intermingled with areas with a glandular pattern. Degenerated neoplastic cells and neutrophils are present between neoplastic papillae.
1433
Image ID:1433
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: a very prominent lymphocytic and plasmacytic infiltration is present in the stroma of the neoplasm at its' periphery. The neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium.
1426
Image ID:1426
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: a very prominent lymphocytic and plasmacytic infiltration is present in the stroma of the neoplasm at its' periphery. The neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium.
1427
Image ID:1427
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is effaced by a multilobular, unencapsulated, densely cellular, neoplasm. Most of the neoplasm has a papillary pattern (P), while one neoplastic lobule has a glandular pattern (G).
1425
Image ID:1425
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is prominent. The papillae are separated by a large amount of amorphous acidophilic material that contains a small number of desquamated and degenerated neoplastic cells intermingled with a few macrophages.
1430
Image ID:1430
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: the neoplasm is composed, in this area, of closely-packed papillae supported by a small amount of fibrovascular stroma. Neoplastic structures are lined by a one cell-thick cuboidal to columnar epithelium. Neoplastic cells have distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles. The nucleus is large, central, oval, hyperchromatic, and with a coarsely-clumped chromatin. Numerous neoplastic cells undergo single cell necrosis and mitotic rate is elevated. Macrophages with a foamy cytoplasm are present in between neoplastic papillae.
1428
Image ID:1428
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is less obvious and is intermingled with areas with a glandular pattern.
1432
Image ID:1432
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is effaced by a multilobular, unencapsulated, densely cellular, neoplasm.
1434
Image ID:1434
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where the papillary pattern is prominent. The papillae are separated by a large amount of amorphous acidophilic material that contains a small number of desquamated and degenerated neoplastic cells intermingled with a moderate number of macrophages with a foamy cytoplasm.
1431
Image ID:1431
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: the lumen of some glands contains apoptotic bodies.
1429
Image ID:1429
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29172 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1bDdp
 Female reproductive status not specified observed unknown Carcinoma in situ, papillary, mammary gland J:94320
Image Caption:Mammary gland: the cellular area in this carcinoma in situ is characterized by epithelial cells piling-up and forming small papillae in a structure that resembles an intralobular duct. This change is associated with mild to moderate interstitial fibrosis and lymphoplasmacytic inflammation. Most neoplastic cells contain lipid vacuoles which are larger and more numerous in the cells lining the dysplastic acini surrounding the most advanced lesions.
1436
Image ID:1436
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this photomicrograp illustrates a portion of the neoplasm where neoplastic cells form discrete papillae that are located in a moderately dilated intralobular duct. Atypia in this area is mild.
1438
Image ID:1438
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this photomicrograp illustrates a portion of the neoplasm where neoplastic cells form discrete papillae that are located in a moderately dilated intralobular duct. Atypia in this area is mild.
1439
Image ID:1439
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally expanded by a nodular, ill-defined, unencapsulated, moderately cellular mass. A more cellular area is present at the center of this mass.
1435
Image ID:1435
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the cellular area in this carcinoma in situ is characterized by epithelial cells piling-up and forming small papillae in a structure that resembles an intralobular duct. This change is associated with mild to moderate interstitial fibrosis and lymphoplasmacytic inflammation. Most neoplastic cells contain lipid vacuoles which are larger and more numerous in the cells lining the dysplastic acini surrounding the most advanced lesions. A few minute areas of cornification (arroheads) are also present.
1437
Image ID:1437
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29173 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1bDdp
 Female reproductive status not specified observed unknown Carcinoma in situ (early stage), mammary gland J:94320
Image Caption:Early stages of in situ mammary carcinoma: this photomicrograph represents the appearance of the mammary gland of this mouse model in the early stages of neoplastic transformation. There is prominent lobular hyperplasia with accumulation of inspissated proteinaceous material in many alveoli and intralobular ducts. Alveoli and intralobular ducts are lined by a prominent epithelium that confers a "crowded" appearance to these structures.
1440
Image ID:1440
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Early stages of in situ mammary carcinoma: this photomicrograph represents the appearance of the mammary gland of this mouse model in the early stages of neoplastic transformation. There is prominent lobular hyperplasia with accumulation of inspissated proteinaceous material in many alveoli and intralobular ducts. Alveoli and intralobular ducts are lined by a prominent epithelium that confers a "crowded" appearance to these structures. Cells do not pile-up disorderly and there is no evidence of atypia. Apoptotic cells are numerous.
1441
Image ID:1441
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29174 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)2Ddp
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, secretory, with squamous differentiation J:94320
Image Caption:Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of squames. Neutrophils infiltrate this portion of the neoplasm.
1450
Image ID:1450
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae and fill neoplastic glands.
1445
Image ID:1445
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation with the formation of nests of cornified cells.
1449
Image ID:1449
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of nests of cornified cells (arrowhead). Cells in this area have distinct cell borders. Cells at various degrees of cornification are also present in the lower portions of the photomicrograph.
1451
Image ID:1451
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: neoplastic glands are cuboidal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm which occasionally contains large lipid vacuoles. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. Neoplastic glands are filled with an inspissated proteinaceous material and desquamated neoplastic cells.
1446
Image ID:1446
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: neoplastic glands are cuboidal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm which occasionally contains large lipid vacuoles. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. Neoplastic glands are filled with an inspissated proteinaceous material and desquamated neoplastic cells.
1447
Image ID:1447
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae.
1443
Image ID:1443
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of transition between a portion of the neoplasm with a glandular pattern (on the left of the photomicrograph) and a portion of the neoplasm with squamous differentiation (on the right of the photomicrophotograph). Squamous differentiation is associated with the formation of nests of cells undergoing cornification (arrowheads) and production of squames (*).
1448
Image ID:1448
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of squamous differentiation that results in the formation of nests of cornified cells and squames.
1452
Image ID:1452
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm. The neoplasm is composed of closely-packed branched papillae and glands supported by a small to moderate amount of fibrovascular stroma. A large amount of coarsely granular material (degenerated neoplastic cells) separate neoplastic papillae.
1444
Image ID:1444
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, polycystic neoplasm.
1442
Image ID:1442
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29175 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)2Ddp
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, secretory, mammary gland J:94320
Image Caption:Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1456
Image ID:1456
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of fibrovascular stroma.
1455
Image ID:1455
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, neoplasm that contains, in its' center, large areas composed of desquamated and degenerated neoplastic cells.
1453
Image ID:1453
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm. There are many mitotic figures.
1460
Image ID:1460
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm.
1459
Image ID:1459
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma: the neoplasm is composed of glands and papillae lined by a one cell-thick cuboidal to low columnar epithelium and supported by a small to moderate amount of collagen-rich fibrovascular stroma. Neoplastic cells are cuboidal to low columnar, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few small vacuoles of lipids. The nucleus is basal to central, medium-sized, oval, and normochromatic. The luminal spaces are filled with degenerated neoplastic cells. The stroma is infiltrated by a moderate number of neutrophils, lymphocytes and plasma cells.
1457
Image ID:1457
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a nodular, unencapsulated, well-delineated, densely cellular, neoplasm that contains, in its' center, large areas composed of desquamated and degenerated neoplastic cells. The neoplasm is composed of thin branched papillae and a few glands supported by a small to moderate amount of fibrovascular stroma.
1454
Image ID:1454
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and secretory mammary adenocarcinoma: this photomicrograph illustrates the papillary pattern of this neoplasm.
1458
Image ID:1458
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29176 Mammary gland   adenoma Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 300 days Adenoma, glandular, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of large nest that have numerous small secondary lumens lined by a one cell-thick cuboidal epithelium. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sixed and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild.
1465
Image ID:1465
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma: a few neoplastic cells are multinucleated (arrowhead). This feature is consistent with aneuploidy and is often observed in tumors with alterations of p53.
1466
Image ID:1466
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens.
1463
Image ID:1463
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm.
1461
Image ID:1461
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens lined by a one cell-thick cuboidal epithelium. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sixed and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild.
1464
Image ID:1464
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, expensile neoplasm. This neoplasm is composed of large nest that have numerous small secondary lumens.
1462
Image ID:1462
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29177 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 300 days Mammary gland - Macrocyst, with atypia J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium.
1468
Image ID:1468
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium.
1467
Image ID:1467
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large polycystic mass lined by a one to two cells-thick cuboidal to tall columnar epithelium. The cells lining the cysts have distinct cell borders and a moderate to large amount of acidophilic cytoplasm that often contain lipid vacuoles of various sizes. The nucleus is randomly located in the cell, is large, oval, hyperchromatic, and with a coarsely clumped chromatin. Anisokaryosis and anisocytosis are prominent. A few mitoses are detected.
1469
Image ID:1469
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29178 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, arising in a macrocyst, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern.
1470
Image ID:1470
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis and formation of small secondary lumens.
1475
Image ID:1475
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic epithelial structures generally are several cells-thick (up to 10 cells-thick) and are characterized by the formation of secondary lumens. Neoplastic cells are large, cuboidal to polygonal, with distinct cell borders and a large amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sized, normochromatic, with a coarsely-clumped chromatin and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild.
1473
Image ID:1473
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis and formation of small secondary lumens. Nuclear palissading is prominent at the periphery of this neoplastic lobule.
1476
Image ID:1476
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern. The epithelial structures generally are several cells-thick (up to 10 cells-thick) and are characterized by the formation of secondary lumens. Neoplastic cells are large, cuboidal to polygonal, with distinct cell borders and a large amount of strongly acidophilic cytoplasm. The nucleus is central, oval, and medium-sized.
1472
Image ID:1472
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, polycystic mass. This mass is composed of papillae and glands with a prominent branching pattern. The morphology of this lesion is similar to that of macrocysts, except that the glandular and papillary areas located at the periphery of the cysts in this tumors are more cellular than in macrocysts.
1471
Image ID:1471
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents portions of the neoplasm characterized by the formation of solid areas with central coagulation necrosis (*) and formation of small secondary lumens.
1474
Image ID:1474
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29179 Mammary gland   hyperplasia - lobular Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Lobular hyperplasia with atypia, mammary gland J:94320
Image Caption:Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent. There is also moderate interstitial lymphocytic and plasmacytic inflammation.
1479
Image ID:1479
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent. There is also moderate interstitial lymphocytic and plasmacytic inflammation.
1480
Image ID:1480
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent.
1477
Image ID:1477
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent, are filled with an often inspissated proteinaceous fluid, and are lined by a prominent epithelium. Luminal cells of all alveoli contain lipid vacuoles and proteinaceous droplets. Anisokaryosis, a common feature of tumors with altered Trp53 expression, is prominent.
1478
Image ID:1478
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29180 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Unspecified reproductive status not specified observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia.
1482
Image ID:1482
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia. Acini are lined by a one cell-thick cuboidal epithelium with prominent small lipid vacuoles and proteinaceous droplets. There is no evidence of atypia.
1483
Image ID:1483
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: two small, non-compressive, expensile, densely cellular nodules are present in a lactating mammary gland.
1481
Image ID:1481
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: the nodule is unencapsulated. It is composed of closely-packed glands and ducts that show various degrees of ectasia. Acini are lined by a one cell-thick cuboidal epithelium with prominent small lipid vacuoles and proteinaceous droplets. There is no evidence of atypia. A few mitoses are present.
1484
Image ID:1484
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29181 Mammary gland   adenoma Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Unspecified reproductive status not specified observed unknown Adenoma, glandular, secretory, mammary gland J:94320
Image Caption:Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is often basal, round to oval, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
1488
Image ID:1488
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is ofetn basal, round to oval, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild.
1487
Image ID:1487
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands lined by a one cell-thick cuboidal epithelium supported by a small amount of fibrovascular stroma. The glands are dilated by a small amount of proteinaceous material. The cells are cuboidal, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often lipid vacuoles and proteinaceous droplets of various sizes. The adjacent mammary gland is lactational.
1486
Image ID:1486
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is focally effaced by a small, nodular, densely cellular neoplastic mass surrounded by a thin fibrous capsule. This neoplasm is composed of closely packed glands supported by a small amount of fibrovascular stroma. The adjacent mammary gland is lactational.
1485
Image ID:1485
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29182 Mammary gland   hyperplasia Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr Tg(WapTgfa)215Bri
 Unspecified reproductive status not specified observed unknown Hyperplasia and atypia, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. Many cells in this area are large and have a large hyperchromatic nucleus with a contoured nuclear membrane. These features are consistent with aneuploidy, a phenomenon that is commonly observed in tumors with altered expression of Trp53. There is also a mild interstitial lymphocytic inflammation.
1490
Image ID:1490
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. A pentapolar mitosis is present.
1491
Image ID:1491
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a portion of the mammary gland that is lactational, hyperplastic, and shows prominent atypia. Many cells in this area are large and have a large hyperchromatic nucleus with a contoured nuclear membrane. These features are consistent with aneuploidy, a phenomenon that is commonly observed in tumors with altered expression of Trp53.
1489
Image ID:1489
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29183 Mammary gland   adenoma Mammary gland None (spontaneous)
FVB/N-Tg(MtTGFA)100Lmb
 Female reproductive status not specified observed unknown Adenoma, glandular, secretory, with atypia, mammary gland J:94320
Image Caption:Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm.
1501
Image ID:1501
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is surrounded by a capsule infiltrated by a small number of lymphocytes and plasma cells. Inflammation extends into the neoplasm which comprises a moderate amount of stroma.
1498
Image ID:1498
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm. One neoplastic cell has a very large nucleus (arrowhead) comparatively to the other neoplastic cells in this field.
1502
Image ID:1502
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: the neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes.
1496
Image ID:1496
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is surrounded by a capsule infiltrated by a small number of lymphocytes and plasma cells. Inflammation extends into the neoplasm which comprises a moderate amount of stroma. There is also moderate anisokaryosis.
1499
Image ID:1499
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm.
1493
Image ID:1493
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: the neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes. The nucleus is often basal, round, and hyperchromatic. Anisokaryosis and anisocytosis are moderate. Mitoses are not found in this field.
1497
Image ID:1497
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma of the mammary gland: this photomicrograph illustrates a portion of the neoplasm that is more cellular and shows more atypia than the rest of the neoplasm.
1500
Image ID:1500
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid. Neoplastic cells have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains numerous lipid vacuoles and proteinaceous droplets of various sizes.
1495
Image ID:1495
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm. The neoplasm is composed of closely-packed glands supported by a moderate amount of fibrovascular stroma. Most of these glands show mild to moderate ectasia and are filled by a proteinaceous fluid.
1494
Image ID:1494
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a large, nodular, well-delineated, encapsulated, expensile, densely cellular neoplasm.
1492
Image ID:1492
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29184 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous)
FVB/N-Tg(MtTGFA)100Lmb
 Female reproductive status not specified observed unknown Macrocyst, mammary gland J:94320
Image Caption:Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1507
Image ID:1507
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.
1510
Image ID:1510
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly expanded by a large nodule that resembles a mammary lobule that has been expanded by a considerable amount of proteinaceous fluid. The large central cysts are interpreted as intralobular ducts. The club-shaped glands that radiate from the central cysts are interpreted as mammary acini.
1503
Image ID:1503
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. Neoplasms may arise within macrocysts.
1508
Image ID:1508
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.
1511
Image ID:1511
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1506
Image ID:1506
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents a more cellular portion of a macrocyst. This area is composed of a few closely-packed glands supported by a small amount of fibrovascular stroma with a mild interstitial lymphocytic and plasmacytic inflammation. This cellular area may represent an evidence of early neoplastic transformation since neoplasms may arise within macrocysts.
1509
Image ID:1509
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this photomicrograph represents the periphery of a macrocyst. The cystic structures are interpreted as dilated mammary acini. The epithelium lining these acini is hyperplastic and some of its' cells contain very large coalescing proteinaceous droplets.
1505
Image ID:1505
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly expanded by a large nodule that resembles a mammary lobule that has been expanded by a considerable amount of proteinaceous fluid. The large central cysts are interpreted as intralobular ducts. The club-shaped glands that radiate from the central cysts are interpreted as mammary acini.
1504
Image ID:1504
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29185 Mammary gland   lesion Mammary gland None (spontaneous)
FVB/N-Tg(MtTGFA)100Lmb
 Female reproductive status not specified observed unknown Lactation responsive plaque, mammary gland J:94320
Image Caption:Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia. A few mitoses are present.
1516
Image ID:1516
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, well-defined, unencapsulated, densely cellular mass. The periphery of this mass is composed of closely-packed glands resembling mammary acini. The center of this mass is composed of duct-like structures embedded in a large amount of loose fibrovascular stroma. These features are consistent with a diagnosis of a "lactation responsive plaque", although this plaque is unusually large.
1512
Image ID:1512
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia.
1514
Image ID:1514
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lactation responsive plaque: the periphery of the mass is composed of closely-packed glands supported by a small amount of fibrovascular stroma. There is no evidence of atypia.
1515
Image ID:1515
Source of Image:Ward JM
Pathologist:Mikaelian I
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, well-defined, unencapsulated, densely cellular mass. The periphery of this mass is composed of closely-packed glands resembling mammary acini. The center of this mass is composed of duct-like structures embedded in a large amount of loose fibrovascular stroma. These features are consistent with a diagnosis of a "lactation responsive plaque", although this plaque is unusually large.
1513
Image ID:1513
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29186 Mammary gland   lesion Mammary gland None (spontaneous)
FVB/N-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Lactation-responsive plaque, mammary gland J:94320
Image Caption:Lactation-responsive plaque: there is no evidence of atypia. The interstitium shows mild to moderate diffuse edema, and is infiltrated by a small number of granulocytes, lymphocytes, plasma cells and macrophages.
1520
Image ID:1520
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by numerous ill-defined to nodular masses characterized by a radiating arrangement of intralobular ducts and acini.
1517
Image ID:1517
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lactation-responsive plaque: lactation responsive plaques are ill-defined to discoid unencapsulated masses composed of acini at the periphery, and ducts at the center. The stroma is more abundant and more edematous at the center at the plaque than at its' periphery. There is no evidence of atypia of the epithelium. Secretory activity is abundant in this case.
1519
Image ID:1519
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lactation-responsive plaque: lactation responsive plaques are ill-defined to discoid unencapsulated masses composed of acini at the periphery, and ducts at the center. The stroma is more abundant and more edematous at the center at the plaque than at its' periphery. There is no evidence of atypia of the epithelium. Secretory activity is abundant in this case.
1518
Image ID:1518
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29187 Mammary gland   fibroadenoma Mammary gland None (spontaneous)
FVB/N-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Fibroadenoma, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses (arrowhead) are detected. The stroma is abundant, contains numerous myofibroblasts, a small number of inflammatory cells, and loosely arranged wavy and thin collagen fibers.
1524
Image ID:1524
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma: this photomicrograph illustrates the branching pattern of neoplastic ducts.
1526
Image ID:1526
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma.
1521
Image ID:1521
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild. A few mitoses (arrowhead) are detected. Myoepithelial differentiation (arrows) is present. The stroma is abundant, contains numerous myofibroblasts, a small number of inflammatory cells, and loosely arranged wavy and thin collagen fibers.
1525
Image ID:1525
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium. Neoplastic ducts are often distended by a proteinaceous fluid. Neoplastic cells have ill-defined cell borders and a moderate amount of a strongly amphophilic cytoplasm that often contains lipid vacuoles.
1523
Image ID:1523
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma: this photomicrograph illustrates a portion of the neoplasm where myoepithelial differentiation (arrowheads) is prominent.
1527
Image ID:1527
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a moderately cellular, encapsulated, well-delineated, expensile, multilobular neoplastic mass. This neoplasm is composed of branching ducts supported by a large amount of cellular stroma. Neoplastic ducts are lined by a one cell-thick cuboidal epithelium.
1522
Image ID:1522
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29188 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB/N-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Hyperlastic alveolar nodule, mammary gland J:94320
Image Caption:Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. A few pigment-ladden macrophages are scattered in the interstitium.
1530
Image ID:1530
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1533
Image ID:1533
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. Interlobular ducts located in the nearby panniculus are normal.
1529
Image ID:1529
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins. The epithelium lining of these glands do not show atypia. There is a mild to moderate interstitial infiltration by lymphocytes, plasma cells, and pigment-ladden macrophages.
1536
Image ID:1536
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins.
1535
Image ID:1535
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1532
Image ID:1532
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a large, encapsulated, well-delineated expensile nodules is composed of closely packed mammary glands with prominent secretion of lipids and proteins.
1534
Image ID:1534
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: mammary lobules are prominent and, although they do not form discrete masses, they contain a proteinaceous fluid and are composed of cuboidal cells with prominent lipid vacuoles. There are least two possible interpretations to this photomicrograph: these alveoli may represent early stages of hyperplastic alveolar nodules, or they may indicate pregnancy.
1531
Image ID:1531
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is very prominent. There is marked ectasia of some but not all acini. All acini and intralobular ducts are lined by a cuboidal epithelium. There is mild interstitial lymphocytic and plasmacytic inflammation. Interlobular ducts located in the nearby panniculus are normal.
1528
Image ID:1528
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29189 Mammary gland   adenoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Adenoma, tubular and glandular, mammary gland J:94320
Image Caption:Mammary adenoma: neoplastic cells form glands with morphologic features consistent with the gestational mammary gland.
1541
Image ID:1541
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma.
1538
Image ID:1538
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, and medium-sized. Anisokaryosis and anisocytosis are mild. Tubules (*) have a "crowded" appearance and resemble intralobular ducts. The glands have morphologic features consistent with the epithelium of mammary acini. There is a mild interstitial infiltration by lymphocytes, plasma cells and macrophages.
1540
Image ID:1540
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed one cell-thick tubules and glands supported by a scant amount of fibrovascular stroma.
1539
Image ID:1539
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally effaced by a small, well-delineated, irregularly-shaped, densely cellular mass. This mass is composed of closely-packed contoured and anastomosed tubules and glands supported by a scant amount of fibrovascular stroma.
1537
Image ID:1537
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29190 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Erbb2)NF1Mul
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.
1548
Image ID:1548
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with a few minute areas of liquefactive necrosis and cavitation.
1542
Image ID:1542
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.
1546
Image ID:1546
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma.
1543
Image ID:1543
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma. Neoplastic cells are medium-sized, polygonal, often with distinct cell borders, and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, medium-sized and slightly hyperchromatic. Anisokaryosis and anisocytosis are mild.
1545
Image ID:1545
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas of epithelial neoplastic cells supported by a scant amount of fibrovascular stroma.
1544
Image ID:1544
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph represents invasion of a mammary adenocarcinoma into an interlobular mammary duct. In the duct, the neoplastic epithelium forms a 2-25 cells-thick layer of cells that occasionally form inconspicuous lumens.
1547
Image ID:1547
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29191 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Erbb2)NF1Mul
 Female reproductive status not specified observed unknown Carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: there was, at the periphery of the solid mammary carcinoma, a dilated interlobular duct that was lined by a 5-10 cells-thick epithelium that often formed small secondary lumens. Myoepithelial differentiation was not identified in this duct. This lesion may represent invasion of an interlobular duct by the solid carcinoma, or may indicate in situ carcinoma in an interlobular duct adjancent to a mammary carcinoma. The formation of a relatively large number of secondary lumens, a feature that was not detected in the solid carcinoma, supports a diagnosis of in situ carcinoma.
1550
Image ID:1550
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there was, at the periphery of the solid mammary carcinoma, a dilated interlobular duct that was lined by a 5-10 cells-thick epithelium that often formed small secondary lumens. Myoepithelial differentiation was not identified in this duct. This lesion may represent invasion of an interlobular duct by the solid carcinoma, or may indicate in situ carcinoma in an interlobular duct adjancent to a mammary carcinoma. The formation of a relatively large number of secondary lumens, a feature that was not detected in the solid carcinoma, supports a diagnosis of in situ carcinoma.
1549
Image ID:1549
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29192 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, secretory, with prominent interstitial fibrosis, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts.
1552
Image ID:1552
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular and secretory adenocarcinoma: myoepithelial differentiation (arrowheads) is often prominent.
1557
Image ID:1557
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts. Neoplastic glands are lined by a two cells-thick epithelium: cells of the basal layer resemble myoepithelial cells of the mammary gland while cells of the luminal layer resemble luminal cells of the mammary gland. Neoplastic luminal cells often contain lipid vacuoles of various sizes.
1554
Image ID:1554
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular neoplasm (only a portion of the neoplasm is present on the slide).
1551
Image ID:1551
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular and secretory adenocarcinoma: this photomicrograph illustrates the ratio between the stroma (approximately 60% of the surface of the section) and the neoplastic epithelial cells (approximately 40% if the surface of the section). Cells in the stroma are oat-shaped to spindloid and resemble myofibroblasts.
1555
Image ID:1555
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, and moderately cellular neoplasm. The neoplasm is composed of interconnected branching ducts embedded is a large amount of a fibrovascular stroma characterized with interstitial edema, deposition of numerous and thick wavy collagen fibers, and the presence of numerous spindloid cells consistent with myofibroblasts. Neoplastic glands are lined by a two cells-thick epithelium: cells of the basal layer resemble myoepithelial cells of the mammary gland while cells of the luminal layer resemble luminal cells of the mammary gland. Neoplastic luminal cells often contain lipid vacuoles of various sizes.
1553
Image ID:1553
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular and secretory adenocarcinoma: mitoses (arrowheads) are detected in myofibroblasts and neoplastic epithelial cells.
1556
Image ID:1556
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29193 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal one cell-thick epithelium supported by a scant amount of connective tissue. Cells lining the glands have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles and proteinaceous droplets. There is no evidence of atypia and cells do not pile-up.
1560
Image ID:1560
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is moderately expanded by small nodules of various sizes. Most of these nodules are well-delineated, unencapsulated, and densely cellular. Some are encapsulated and slightly compress the adjacent tissues. There is mild to moderate interstitial fibrosis and moderate ductal and alveolar ectasia in the remaining portions of the mammary gland.
1558
Image ID:1558
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal epithelium.
1559
Image ID:1559
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by small, well-delineated, unencapsulated, and densely cellular nodule. This nodule is composed of closely packed glands and intralobular ducts which show mild to moderate ectasia and contain an amorphous proteinaceous fluid. Alveoli and ducts are lined by a cuboidal one cell-thick epithelium supported by a scant amount of connective tissue. Cells lining the glands have indistinct cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles and proteinaceous droplets. There is no evidence of atypia and cells do not pile-up. A moderate number of epithelial cells undergo apoptosis.
1561
Image ID:1561
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29194 Mammary gland   cyst - macrocyst Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Macrocyst, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilocular mass. The cysts that make up most of this mass contain an inspissated proteinaceous material and are lined by a 2 cells-thick cuboidal epithelium that, in a few areas, forms secondary glands.
1564
Image ID:1564
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: the cystic spaces are filled with an amorphous acidophilic material. Numerous small glands radiate from the smaller cysts.
1567
Image ID:1567
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocysts: the epithelium surrounding the major cyst is once cell-thick and is composed of attenuated cells. The epithelium lining the glands is cuboidal. There is no evidence of atypia. The proteinaceous material in the lumen of the glands often is inspissated. There is no evidence of atypia.
1569
Image ID:1569
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilocular mass. The cysts that make up most of this mass contain an inspissated proteinaceous material and are lined by a 2 cells-thick cuboidal epithelium.
1563
Image ID:1563
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: this low power magnification illustrates the cystic appearance of most macrocyts, and also the connection between the larger cyst and smaller cysts that radiate from the largest cyst. Small adenomas are present at the periphery of the macrocyst.
1566
Image ID:1566
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilocular mass.
1562
Image ID:1562
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: as exemplified on this photomicrograph, mitotic activity (arrowheads) is multifocally prominent. The cells lining the ducts and the cysts are cuboidal to low columnar, have indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains lipid vacuoles. The nucleus tends to be basal, is medium-sized, round to oval and normochromatic. Anisokaryosis and anisocytosis are mild. There is a moderate interstitial granulocytic (eosinophilic?) infiltration.
1565
Image ID:1565
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Macrocyst: the cystic spaces are filled with an amorphous acidophilic material. Numerous small glands radiate from the smaller cysts. The cysts and the glands are lined by a 1-2 cells-thick epithelium supported by a small to moderate amount of fibrovascular stroma.
1568
Image ID:1568
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29195 Mammary gland   adenoma Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Adenoma, glandular, secretory, mammary gland J:94320
Image Caption:Mammary gland, small glandular adenoma: the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. This mass is composed of small glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma. Some glands are ectatic and are filled with an amorphous proteinaceous fluid.
1571
Image ID:1571
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma, small glandular adenoma: cells lining neoplastic glands are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains small lipid vacuoles.
1572
Image ID:1572
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma.
1577
Image ID:1577
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma.
1576
Image ID:1576
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. Similar smaller masses and hyperplastic alveolar nodules distort the remaining portions of the mammary gland.
1575
Image ID:1575
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): mitoses (arrowheads) are numerous in some fields.
1579
Image ID:1579
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. Similar smaller masses and hyperplastic alveolar nodules distort the remaining portions of the mammary gland.
1574
Image ID:1574
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): this photomicrograph illustrates the glandular pattern of this adenoma.
1580
Image ID:1580
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular adenoma (small): cells lining neoplastic glands are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains proteinaceous droplets (arrow) or small lipid vacuoles. The nucleus is central, round, medium-sized and normochromatic. Anisocytosis and anisokaryosis are mild. A moderate number of mitoses (arrowheads) is present.
1573
Image ID:1573
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary glandular adenoma (large): the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. The neoplasm is composed of closely-packed glands lined by a one cell-thick cuboidal epithelium supported by a scant amount of fibrovascular stroma. Most glands are filled with an occasionally inspissated proteinaceous fluid. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that often contains a few small lipid droplets. The nucleus generally is basal, round to oval, medium-sized, and normochromatic. Anisokaryosis and anisocytosis are mild.
1578
Image ID:1578
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland, small glandular adenoma: the mammary gland is effaced by a large, nodular, encapsulated, densely cellular mass. This mass is composed of small glands supported by a scant amount of fibrovascular stroma.
1570
Image ID:1570
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29196 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.
1581
Image ID:1581
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.
1583
Image ID:1583
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule (early stage): the lobular architecture of the mammary gland is enhanced. Alveoli and intra-lobular ducts are lined by a one cell-thick cuboidal epithelium and are often filled with a moderate amount of proteinaceous material. There is mild interstitial fibrosis and lymphoplasmacytic inflammation. There is no evidence of atypia.
1582
Image ID:1582
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29197 Mammary gland   fibroadenoma Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 300 days Fibroadenoma, secretory, with atypia, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid.
1586
Image ID:1586
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma. A few neoplastic cells are multinucleated (arrowhead).
1593
Image ID:1593
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid.
1585
Image ID:1585
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates the bi-stratified feature of the neoplasm. Arrowheads point at cells with myoepithelial differentiation.
1597
Image ID:1597
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma. Small clusters of cells seem to be engaged in the early stages of cornificatin (arrowhead).
1594
Image ID:1594
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates portion of the neoplasm with a fibrous stroma (to the left of the photomicrograph) and other portions of the neoplasm with a cellular stroma.
1595
Image ID:1595
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates the bi-stratified feature of the neoplasm. Cells with myoepithelial differentiation are difficult to differentiate from stromal cells, and are best identified with immunolabeling for myoepithelial cell markers (keratins 5, 14 and 17, alpha smooth muscle actin, p63, caldesmon, ...).
1598
Image ID:1598
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid oaccasionally admixed with a coarse granular yellow-brown pigment.
1587
Image ID:1587
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates portion of the neoplasm with a fibrous srtoma (to the left of the photomicrograph) and other portions of the neoplasm with a cellular stroma. Mitoses are not rare, even in the most immature portions of the neoplasm.
1596
Image ID:1596
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma.
1584
Image ID:1584
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: the neoplasm is composed of dilated glands filled with a proteinaceous material and embedded in a large amount of dense fibrovascular stroma. There are two layers to the neoplastic epithelium: (1) a luminal layer composed of cuboidal cells that often contain lipid vacuoles and occasionally proteinaceous droplets; (2) an inconspicuous basal (=myoepithelial) layer. There is no evidence of atypia in this microscopic field.
1589
Image ID:1589
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia.
1590
Image ID:1590
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, encapsulated, moderately cellular, expensile neoplasm. There is moderate diffuse lobular hyperplasia and secretory activity in the adjacent mammary parenchyma. The neoplasm is composed of contoured glands lined by a two cells-thick epithelium supported by a large amount of fibrovascular stroma. Many glands are ectatic and are filled with an amorphous proteinaceous fluid oaccasionally admixed with a coarse granular yellow-brown pigment.
1588
Image ID:1588
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too.
1591
Image ID:1591
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Fibroadenoma with atypia: this photomicrograph illustrates a portion of the neoplasm composed of small glands with atypia. Neoplastic cells are large and most of them contain a large lipid vacuole. The nuclei are large, too, and there is moderate anisokaryosis. There is a moderate granulocytic (eosinophilic?; predominantly), lymphocytic and plasmacytic inflammation of the stroma.
1592
Image ID:1592
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29198 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
 Female reproductive status not specified observed 120 days Adenocarcinoma, solid, comedo, mammary gland J:94320
Image Caption:Comedo mammary adenocarcinoma: neoplastic cells are medium-size, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is medium-size, oval, hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Numerous neoplastic cells undergo single cell necrosis. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1603
Image ID:1603
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, invasive, densely cellular neoplasm. The neoplasm is composed of thick interconnected cords with prominent central liquefactive necrosis and supported by a small to moderate amount of fibrovascular stroma.
1599
Image ID:1599
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Comedo mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where cells form 1-2 cells thick cords. It is often at the vicinity of these areas that epithelial to mesenchymal transition occurs.
1601
Image ID:1601
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, invasive, densely cellular neoplasm. The neoplasm is composed of thick interconnected cords with prominent central liquefactive necrosis and supported by a small to moderate amount of fibrovascular stroma. Small secondary lumens are occasionally detected (arrowheads). Neoplastic cells are medium-sized, polygonal to spindloid, with indistinct cell borders and they have a moderate amount of strongly amphophilic cytoplasm.
1600
Image ID:1600
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Comedo mammary adenocarcinoma: this photomicrograph illustrates areas of the neoplasm that is predominantly solid with large central areas of liquefactive necrosis. In addition, neoplastic cells form a few lumens.
1602
Image ID:1602
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29199 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
 Female reproductive status not specified observed 120 days Adenocarcinoma, circumscribed, solid, comedo, glandular, mammary gland J:94320
Image Caption:Comedo mammary adenocarcinoma: the neoplasm is composed of thick trabeculae and solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells occasionally form inconspicuous lumens (arrowhead). Neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central and oval.
1607
Image ID:1607
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Comedo mammary adenocarcinoma: the neoplasm is composed of thick trabeculae and solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic, with 1-2 large basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous neoplastic cells undergo single cell necrosis.
1608
Image ID:1608
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.
1604
Image ID:1604
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.
1605
Image ID:1605
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of closely packed glands and thick trabeculae with prominent central liquefactive necrosis.
1606
Image ID:1606
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29200 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
 Female reproductive status not specified observed 120 days Adenocarcinoma, papillary, circumscribed, mammary gland J:94320
Image Caption:Papillary adenocarcinoma: neoplastic cells are columnar to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic, and with 1-3 small to medium-sized strongly basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous degenerated neoplastic cells have desquamated.
1611
Image ID:1611
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a small, nodular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of coalescing papillae supported by a small amount of fibrovascular stroma and lined by a (predominantly) one cell-thick columnar epithelium. Neoplastic cells often pile-up disorderly.
1609
Image ID:1609
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a small, nodular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of coalescing papillae supported by a small amount of fibrovascular stroma and lined by a (predominantly) one cell-thick columnar epithelium. Neoplastic cells often pile-up disorderly or form small secondary lumens.
1610
Image ID:1610
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29201 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
B6;SJL-Tg(Mt1-Tgfa)147Bri Tg(WapMyc)212Bri
 Female reproductive status not specified observed 120 days Adenocarcinoma, solid, with secondary lumens and epithelial to mesenchymal transition J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules that are made up of solid areas with secondary lumens.
1614
Image ID:1614
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid. Neoplastic spindloid cells are difficult to differentiate from stromal myofibroblasts. Individual spindloid neoplastic cells are present in the stroma.
1624
Image ID:1624
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules of various size that are made up of glands (predominantly) and solid areas. These lobules are separated by a small amount of fibrovascular stroma.
1612
Image ID:1612
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a neoplastic lobule with prominent secondary lumens has prominent central coagulation necrosis.
1621
Image ID:1621
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the largest solid areas have central liquefactive necrosis and have a comedo-type pattern. All solid areas contain secondary lumens filled by a proteinaceous fluid.
1615
Image ID:1615
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid.
1622
Image ID:1622
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with epithelial to mesenchymal transition. Neoplastic cells form one cell-thick trabeculae and become spindloid. Neoplastic spindloid cells are difficult to differentiate from stromal myofibroblasts.
1623
Image ID:1623
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the largest solid areas have central liquefactive necrosis and have a comedo-type pattern (*). All solid areas contain secondary lumens filled by a proteinaceous fluid.
1616
Image ID:1616
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with a a solid pattern and with numerous secondary lumens (*). Nearby neoplastic lobules have a more classical solid pattern with large central areas of liquefactive necrosis ("comedo" pattern).
1619
Image ID:1619
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with a pattern intermediate between a glandular pattern and a solid pattern. Numerous secondary lumens (*) are present.
1618
Image ID:1618
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a neoplastic lobule with prominent secondary lumens has prominent central coagulation necrosis.
1620
Image ID:1620
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilobular, unencapsulated, densely cellular neoplasm. This neoplasm is composed of lobules that are made up of solid areas with secondary lumens.
1613
Image ID:1613
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the secondary lumens are filled by a proteinaceous fluid. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, slightly hypochromatic, with a stippled chromatin and 1-2 medium-sized and strongly basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1617
Image ID:1617
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29202 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri Tg(WapTgfa)215Bri
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, comedo, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis.
1627
Image ID:1627
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis, which gives a pseudo-glandular pattern to the neoplasm when examined at low magnification.
1625
Image ID:1625
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas supported by a small amount of fibrovascular stroma. Neoplastic cells are medium-sized to large, polygonal, with ill-defined cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-size, occasionally with a slightly contoured nuclear membrane, slightly hypochromatic and with 1-3 medium size basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. A moderate number of neoplastic cells undergoes apoptosis. Necrosis and cavitation are present at the center of the largest trabeculae.
1628
Image ID:1628
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma with comedo pattern: this photomicrograph illustrates a portion of the neoplasm with prominent necrosis and early cavitation at the center of the solid areas. The cavitated area contains degenerated neoplastic cells.
1630
Image ID:1630
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma with comedo pattern: this photomicrograph illustrates a portion of the neoplasm with prominent necrosis and early cavitation at the center of the solid areas.
1629
Image ID:1629
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, expensile, densely cellular neoplasm. This neoplasm is composed of solid areas with central necrosis supported by a small amount of fibrovascular stroma.
1626
Image ID:1626
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29203 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
B6;C-Tg(MMTV-RET)127Ina
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.
1632
Image ID:1632
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.
1633
Image ID:1633
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. There is a mild lymphocytic and granulocytic infiltrate at the periphery of the neoplasm.
1636
Image ID:1636
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally expanded by a nodular, densely cellular, expensile neoplastic mass surounded by a thin fibrous capsule. This neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma.
1631
Image ID:1631
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli.
1635
Image ID:1635
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed glands with a narrow lumen, lined by a one cell-thick cuboidal epithelium, and supported by a small amount of fibrovascular stroma. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, generally basal, medium-sized, normochromatic, with a finely stippled chromatin and 1-4 medium-sized basophilic nucleoli.
1634
Image ID:1634
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29204 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
B6;C-Tg(MMTV-RET)127Ina
 Female reproductive status not specified observed unknown Carcinoma in situ, mammary gland J:94320
Image Caption:In situ mammary carcinoma: there is, at the vicinity of a large glandular carcinoma (*) a neoplastic lobules that shows prominent proliferation of its' cells. Cells in this lobule pile-up disorderly and distend a few alveoli (arrowhead). The architecture of the lobule is preserved. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1637
Image ID:1637
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: there is prominent proliferation of cells in all mammary alveoli and intralobular ducts. These cells occasionally form solid areas that expand mammary alveoli and acini. Proliferating cells are large, with indistinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of invasion. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1638
Image ID:1638
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: there is moderate proliferation of epithelial cells of all alveoli and ducts with occlusion of the ductal and alveolar lumen. Myoepithelial differentiation (arrowheads) is present in this portion of the lesion.
1640
Image ID:1640
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: there is prominent proliferation of cells in a mammary alveolus. Thin fibrovascular projections subdivide the alveolus. Proliferating cells are large, with indistinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of invasion. There is mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation. Myoepithelial differentiation is not detected in this portion of the lesion.
1639
Image ID:1639
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29205 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
B6;C-Tg(MMTV-RET)127Ina
 Female reproductive status not specified observed unknown Carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: hypercellularity of mammary lobules is the result of proliferation of luminal cells of mammary alveoli and intralobular ducts. These cells pile-up and occlude the lumen of some alveoli. There is no evidence of local invasion.
1642
Image ID:1642
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: hypercellularity of mammary lobules is the result of proliferation of luminal cells of mammary alveoli and intralobular ducts. These cells pile-up and occlude the lumen of some alveoli. The cells populating this lobule are very heterogeneous. About 30% of these cells have primitive features: they are oval, with a pale acidophilic cytoplasm and a medium-sized slightly hypochromatic nucleus. The other cells are more differentiated and have a cuboidal to low columnar shape, a more strongly acidophilic cytoplasm and a normochromatic nucleus. There is no evidence of atypia but a few mitoses (arrowheads) are detected. There is no evidence of local invasion. There is mild interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1643
Image ID:1643
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is marked diffuse hypercellularity of two adjacent mammary lobules.
1641
Image ID:1641
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds.
1645
Image ID:1645
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds. There is mild interstitial fibrosis and lymphocytic and plasmacytic inflammation.
1646
Image ID:1646
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary gland is moderately increased in size. Most alveoli are slightly expanded by a proteinaceous material and are lined by an hypercellular epithelium. Some alveoli are filled with epithelial cells and resemble terminal end buds.
1644
Image ID:1644
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29206 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
B6;C-Tg(MMTV-RET)127Ina
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1647
Image ID:1647
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm.
1651
Image ID:1651
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is basal, often oriented in the long axis of the cell, medium-sized,normochromatic, with a finely stippled chromatin and 1-2 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
1652
Image ID:1652
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. There is mild lymphocytic and plasmacytic inflammation in the capsule of the neoplasm.
1650
Image ID:1650
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1649
Image ID:1649
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, densely cellular neoplastic mass surrounded by a thin capsule. The neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. A few areas of liquefactive necrosis are scattered throughout the neoplasm.
1648
Image ID:1648
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed branching glands with an inconspicuous lumen. These glands are lined by a one cell-thick epithelium and are supported by a small amount of fibrovascular stroma. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is basal, often oriented in the long axis of the cell, medium-sized,normochromatic, with a finely stippled chromatin and 1-2 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
1653
Image ID:1653
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29207 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
B6;C-Tg(MMTV-RET)127Ina
 Female reproductive status not specified observed unknown Carcinoma in situ, mammary gland J:94320
Image Caption:In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1659
Image ID:1659
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1660
Image ID:1660
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. A small focus of cornification (arrowhead) is present.There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1655
Image ID:1655
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely packed epithelial cells that form solid areas and small glands with an inconspicuous lumen. The cells are polygonal, with distinct cell borders and a moderate amount of pale acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hypochromatic. Anisokaryosis and anisocytosis are mild. There is no evidence of local invasion. Mitotic figures are numerous. There is moderate interstitial lymphocytic and plasmacytic inflammation and fibrosis. Myoepithelial differentiation is prominent and appears as a continuous layer of cells with a nucleus oriented parallel to the basement membrane and a scant amount of cytoplasm.
1656
Image ID:1656
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this represents an early stage of in situ mammary carcinoma: the architecture of the mamamry gland is preserved but mammary lobules are packed with epithelial cells and often lack a lumen. Numerous cells in the mammary gland are round, have a very pale cytoplasm with a ground glass appearance, and have a medium-sized hypochromatic nucleus. These features are consistent with the features of a primitive epithelial cell. There is mild to moderate interstitial lymphocytic and plasmacytic inflammation. Myoepithelial differentiation is still detected and myoepithelial cells appear as cells with an ellongated nucleus parallel to the basement membrane and a scant amount of cytoplasm.
1658
Image ID:1658
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this low magnification photomicrograph represents portions of a mammary gland with areas of in situ mammary carcinoma (at the center of the photomicrographs) with multiple areas of atypical hyperplasia more at the periphery of the neoplasm. There is moderate intersitial fibrosis and lymphoplasmacytic inflammation that involves all mammary lobules.
1662
Image ID:1662
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this represents an early stage of in situ mammary carcinoma: the architecture of the mamamry gland is preserved but mammary lobules are packed with epithelial cells and often lack a lumen. Numerous cells in the mammary gland are round, have a very pale cytoplasm with a ground glass appearance, and have a medium-sized hypochromatic nucleus. These features are consistent with the features of a primitive epithelial cell. There is mild to moderate interstitial lymphocytic and plasmacytic inflammation.
1657
Image ID:1657
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is moderate diffuse expansion of a mammary lobule. Within this lobule, a few acini are markedly expanded by closely-packed epithelial cells that form solid areas and small glands with an inconspicuous lumen.
1654
Image ID:1654
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:In situ mammary carcinoma: this photomicrograph represents the transition from the early stages of in situ mammary carcinoma to a more advanced stage of the disease (at the center of the photomicrograph). Myoepithelial differentiation is prominent in the areas of early in situ mammary carcinoma. It is still present but difficult to identify in the more advance areas. Cells in the more advanced areas are larger, with pale acidophilic cytoplasm and a medium-sized hypochromatic nucleus. Cells in the least advanced areas are smaller and have a smaller and normo- to hyperchromatic nucleus. There is no evidence of invasion. There is mild interstitial lymphocytic and plasmacytic inflammation and fibrosis.
1661
Image ID:1661
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29230 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, glandular, mammary gland J:94320
Image Caption:Solid mammary adenocarcinoma: the tumor is well-delineated and expensile.
1669
Image ID:1669
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with glandular differentiation.
1667
Image ID:1667
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a few areas of glandular differentiation (arrowheads) are identified in a neoplasm that otherwise has a solid phenotype.
1666
Image ID:1666
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is entirely effaced by a densely cellular neoplasm with large areas of central liquefactive necrosis (*).
1663
Image ID:1663
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is entirely effaced by a densely cellular neoplasm with large areas of central liquefactive necrosis (*). This neoplasm is predominantly composed of large solid areas made-up of closely-packed neoplastic cells.
1665
Image ID:1665
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma:the neoplasm is composed of thick trabeculae and solid areas with prominent nuclear palissading at the periphery of these areas.
1670
Image ID:1670
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is entirely effaced by a densely cellular neoplasm with large areas of central liquefactive necrosis. This neoplasm is predominantly composed of large solid areas made-up of closely-packed neoplastic cells.
1664
Image ID:1664
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm with glandular differentiation.
1668
Image ID:1668
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: neoplastic cells are medium-sized, polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round to oval, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild.
1671
Image ID:1671
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29231 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is replaced by multiple, nodular, unencapsulated, well-delineated, densely cellular neoplasms. These neoplasm often display central liquefactive necrosis and cavitation (*).
1673
Image ID:1673
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of solid areas of closely-packed polygonal neoplastic cells with indistinct cell borders. There are, at the periphery of the neoplasm, small clusters of neoplastic cells that have a paler cytoplasm, and a larger and more hypochromatic nucleus than neoplastic cells in the rest of the neoplasm.
1674
Image ID:1674
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: there are three morphologic types of neoplastic cells. First, at the periphery of the neoplasms, there are small clusters of large cells with a pale cytoplasm and an hypochromatic nucleus. Second, around the areas of liquefactive necrosis, neoplastic cells are small, with a condensed nucleus and a small amount of cytoplasm. Third, acounting for the majority of neoplastic cells, there is a population of medium-sized polygonal cells with indistinct cell borders, a moderate amount of strongly acidophilic cytoplasm, and a medium-sized central normochromatic nucleolus.
1678
Image ID:1678
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of solid areas of closely-packed polygonal neoplastic cells with indistinct cell borders. There are, at the periphery of the neoplasm, small clusters of neoplastic cells that have a paler cytoplasm, and a larger and more hypochromatic nucleus than neoplastic cells in the rest of the neoplasm.
1676
Image ID:1676
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this high magnification picture represents a peripheral portion of a neoplasm. There is a cluster of large neoplastic cells, while most neoplastic cells are medium-sized and have a more acidophilic cytoplasm. The arrowhead points to a minute lumen.
1679
Image ID:1679
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm that comprises areas of liquefactive necrosis), a cluster of large neoplastic cells with a pale cytoplasm (*) and small areas composed of small cells with a small amount of strongly acidophilic cytoplasm and an hyperchromatic nucleus (arrowheads). The rest of the neoplasm is composed of medium-sized cells with a moderate amount of acidophilic cytoplasm and a medium-sized normochromatic nucleus.
1680
Image ID:1680
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of solid areas of closely-packed polygonal neoplastic cells with indistinct cell borders. There are, at the periphery of the neoplasm, small clusters of neoplastic cells that have a paler cytoplasm, and a larger and more hypochromatic nucleus than neoplastic cells in the rest of the neoplasm.
1675
Image ID:1675
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of solid areas of closely-packed polygonal neoplastic cells with indistinct cell borders. There are, at the periphery of the neoplasm, small clusters of neoplastic cells that have a paler cytoplasm, and a larger and more hypochromatic nucleus than neoplastic cells in the rest of the neoplasm.
1677
Image ID:1677
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by multiple, nodular, unencapsulated, well-delineated, densely cellular neoplasms. These neoplasm often display central liquefactive necrosis and cavitation (*).
1672
Image ID:1672
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29232 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Solid mammary adenocarcinoma: a narrow rim of neoplastic cells survives at the periphery of the blood vessels located in the areas of liquefactive necrosis. The rest of the neoplasm is composed of solid areas separated by a small amount of fibrous stroma. There is prominent nuclear palissading at the periphery of neoplastic lobules.
1684
Image ID:1684
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates the morphology of the periphery of the neoplasm. Neoplastic cells, in this area, are large, have a moderate amount of pale acidophilic cytoplasm, and have a medium-sized hypochromatic nucleus. Mitotic activity is elevated. Neoplastic cells occasionally form inconspicuous lumens (*).
1686
Image ID:1686
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of two types of neoplastic cells. First, at the periphery of the neoplasm, there are small ill-defined clusters of large neoplastic cells with a pale cytoplasm and an hypochromatic nucleus. Second, accounting for most of the neoplasm, there are medium-sized polygonal cells with indistinct cell borders and a moderate amount of acidophilic cytoplasm. Anisokaryosis and anisocytosis are mild. Neoplastic cells occasionally form inconspicuous secondary lumens (arrowhead).
1685
Image ID:1685
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a narrow rim of neoplastic cells survives at the periphery of the blood vessels located in the areas of liquefactive necrosis. The rest of the neoplasm is composed of solid areas separated by a small amount of fibrous stroma.
1683
Image ID:1683
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large multilobular neoplasm with large central areas of liquefactive necrosis (*).
1681
Image ID:1681
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large multilobular neoplasm with large central areas of liquefactive necrosis (*).
1682
Image ID:1682
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29233 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Solid mammary adenocarcinoma: only a thin rim of viable neoplastic cells persist. Other neoplastic cells have undergone liquefactive necrosis.
1692
Image ID:1692
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: the neoplasm is composed of solid areas of neoplastic cells with large coalescing areas of liquefactive necrosis. Neoplastic cells are closely-packed, polygonal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild.
1689
Image ID:1689
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: the neoplasm is composed of solid areas of neoplastic cells with large coalescing areas of liquefactive necrosis. Neoplastic cells are closely-packed, polygonal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, medium-sized and normochromatic. Anisokaryosis and anisocytosis are mild.
1690
Image ID:1690
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is entirely effaced by a densely cellular multilobular neoplasm with large central areas of liquefactive necrosis. In many places, viable neoplastic cells persists only as a narrow rim surrounding blood vessels.
1688
Image ID:1688
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: neoplastic cells occasionally form small secondary lumens (*). Liquefactive necrosis (N) is prominent in areas located far away from blood vessels.
1691
Image ID:1691
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is entirely effaced by a densely cellular multilobular neoplasm with large central areas of liquefactive necrosis. In many places, viable neoplastic cells persists only as a narrow rim surrounding blood vessels.
1687
Image ID:1687
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29234 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, comedo, with microinvasion, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, multilobular, unencapsulated, densely cellular, neoplastic mass. This mass is composed of large coalescing lobules separated by a scant amount of loose fibrovascular stroma with large ectatic vascular spaces (*). Necrosis and cavitation are common in most neoplastic lobules. The portion of the neoplasm located at the center of the photomicrograph is composed of large polygonal cells with distinct cell borders, a large amount of acidophilic cytoplasm, and medium-size hypochromatic nuclei. The portions of the neoplasm located at the periphery of this photomicrograph are composed of crowded small cells with indistinct cell borders, a small amount of acidophilic cytoplasm, and a slightly smaller and more hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1695
Image ID:1695
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, multilobular, unencapsulated, densely cellular, neoplastic mass. This mass is composed of large coalescing lobules separated by a scant amount of loose fibrovascular stroma. Necrosis and cavitation are common in most neoplastic lobules.
1694
Image ID:1694
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the portion of the neoplasm located at the center of the photomicrograph is composed of large polygonal cells with distinct cell borders, a large amount of acidophilic cytoplasm, and medium-size hypochromatic nuclei. The portions of the neoplasm located at the periphery of this photomicrograph are composed of crowded small cells with indistinct cell borders, a small amount of acidophilic cytoplasm, and a slightly smaller and more hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1696
Image ID:1696
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with microinvasion: this photomicrograph illustrates an area of invasion of the stroma. Invasion occurs in the form of clusters (arrow) or individual cells (arrowhead).
1700
Image ID:1700
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells are large, although small neoplastic cells (*) are also present.
1699
Image ID:1699
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm composed of large neoplastic cells (on the right of the photomicrograph) separated by a large vascular space from a portion of the neoplasm composed of smaller cells with less cytoplasm, and smaller and slightly more hyperchromatic nucleus. Mitoses are more numerous in the portion of the neoplasm composed of large neoplastic cells.
1697
Image ID:1697
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, nodular, multilobular, unencapsulated, densely cellular, neoplastic mass. This mass is composed of large coalescing lobules separated by a scant amount of loose fibrovascular stroma. Necrosis and cavitation are common in most neoplastic lobules.
1693
Image ID:1693
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with microinvasion: this high power photomicrograph illustrates an area of invasion of the stroma. Invasion occurs in the form of clusters or individual cells (arrowhead). Invasion in this model is not associated with epithelial to mesenchymal transition.
1701
Image ID:1701
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates an asymmetrical mitotic figure (arrowhead). Asymmetrical figures generally are not observed in mice transgenic for neu. However, mice transgenic for neu and with Trp53 mutations often develop tumors with prominent asymmetrical mitotic figures. A few neoplastic cells at the right of the photomicrograph contain lipid vacuoles. A few neoplastic cells at the left of the photomicrograph are undergoing single cell necrosis.
1698
Image ID:1698
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29236 Mammary gland   adenocarcinoma Lung None (spontaneous)
FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, mammary gland, metastatic to the lung J:94320
Image Caption:Lung: a small metastasis of a mammary tumor is present. This metastasis is predominantly composed of cell located within the lumen of a small artery (neoplastic embolus), but also of neoplastic cells that have escaped the lumen of the artery to invade the pulmonary interstitial (true metastasis).
1703
Image ID:1703
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a small metastasis of a mammary tumor is present.
1702
Image ID:1702
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a small metastasis of a mammary tumor is present. This metastasis is predominantly composed of cell located within the lumen of a small artery (neoplastic embolus), but also of neoplastic cells that have escaped the lumen of the artery to invade the pulmonary interstitial (true metastasis). The endothelium of the artery (arrowhead) is still discernible. Neoplastic cells are polygonal, with ill-defined cell borders and a moderate amount of homogeneous acidophilic cytoplasm. Anisocytosis and anisokaryosis are mild. Nearby alveoli contain macrophages the cytoplasm of which is distended by acidophilic crystals (acidophilic crystals pneumonia).
1704
Image ID:1704
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29237 Mammary gland   adenoacanthoma Mammary gland None (spontaneous)
FVB/N-Tg(Rr28-Igf2)1aDdp
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, with keratinization (adenoacanthoma), mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium (predominantly) and trabeculae supported by a small amount of fibrovascular stroma. There are multiple small areas of abrupt keratinization that result into the formation of small rafts of "ghost" epithelial cells, a feature reminicent of keratinization in pilomatricomas. A small number of neutrophils, lymphocytes and plasma cells is present in the stroma.
1708
Image ID:1708
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium (predominantly) and trabeculae supported by a small amount of fibrovascular stroma. There are multiple small areas of keratinization that result into the formation of small "keratin pearls".
1709
Image ID:1709
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium (predominantly) and trabeculae supported by a small amount of fibrovascular stroma. There are multiple small areas of keratinization characterized by the presence of keratohyalin granules (arrowhead) and that result into the formation of small "keratin pearls". Some neoplastic ducts have ruptured and cornified material has leaked into the stroma, causing a mild granulomatous reaction (arrow).
1710
Image ID:1710
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma has been effaced by a densely cellular, nodular, unencapsulated neoplasm. This neoplasm is composed of interconnected ducts supported by a small amount of fibrovascular stroma.
1705
Image ID:1705
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium (predominantly) and trabeculae supported by a small amount of fibrovascular stroma. There are multiple small areas of abrupt keratinization that result into the formation of small rafts of "ghost" epithelial cells (arrowhead), a feature reminicent of keratinization in pilomatricomas.
1707
Image ID:1707
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma has been effaced by a densely cellular, nodular, unencapsulated neoplasm. This neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium (predominantly) and trabeculae supported by a small amount of fibrovascular stroma.
1706
Image ID:1706
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29238 Mammary gland   adenoma Mammary gland Chemical/Drug pituitary isograft, 7,12-dimethylbenz[a]anthracene (DMBA)
FVB-Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenoma, glandular, with prominent atypia, and diffuse hyperplasia with atypia, mammary gland J:94320
Image Caption:Mammary adenoma: this photomicrograph of the periphery of the neoplasm illustrates the radiating glandular pattern with gradual transition into cords and trabeculae. Neoplastic cells are medium-sized, polygonal to cuboidal, with indistinct cell borders and a moderate amount of homogeneously eosinophilic cytoplasm. The nucleus is basal, round, and normochromatic. Anisocytosis and anisokaryosis overal are mild, although a few cells have a very large nucleus (arrowhead). There is prominent hyperplasia and atypia in the nearby mammary parenchyma.
1717
Image ID:1717
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenoma: this photomicrograph illustrates the glandular pattern that was present in the peripheral portions of the neoplasm. A few neoplastic cells have very large nuclei (arrowhead). Most glands are mildly ectatic and they are filed with an inspissated proteinaceous fluid.
1718
Image ID:1718
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the microadenoma is composed of closely-packed glands lined by a one cell-thick low columnar epithelium and supported by a small amount of fibrovascular stroma. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm that occasionally contains a few lipid vacuoles. The nucleus is basal, round, medium-sized and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild. A few mitoses, including asymmetrical mitoses (arrowhead) are noted.
1714
Image ID:1714
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenoma: this photomicrograph illustrates the trabecular pattern that was present in the central areas of the neoplasm. Neoplastic cells are crowded.
1719
Image ID:1719
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is small, encapsulated, densely cellular, and expensile. It is composed of radiating glands with, at the center of the neoplasm, trabeculae and cords of neoplastic cells. The glands are lined by a one cell-thick cuboidal epithelium. There is a small amount of loose fibrovascular stroma with a mild lymphocytic and plasmacytic infiltrate that is most abundant at the center of the neoplasm.
1716
Image ID:1716
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is diffuse hyperplasia of the mammary gland with mild to moderate diffuse lactation. In addition, at the center of the tissue, there is a small, encapsulated, densely cellular, expensile neoplastic nodule (arrowheads; early stage of a glandular adenoma).
1712
Image ID:1712
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is diffuse hyperplasia of the mammary gland with mild to moderate diffuse lactation. In addition, at the center of the tissue, there is a small, encapsulated, densely cellular, expensile neoplastic nodule (early stage of a glandular adenoma). The nodule is composed of closely-packed glands lined by a one cell-thick low columnar epithelium and supported by a small amount of fibrovascular stroma. Neoplastic cells are low columnar, with indistinct cell borders and a moderate amount of acidophilic cytoplasm that occasionally contains a few lipid vacuoles. The nucleus is basal, round, medium-sized and normochromatic. Anisokaryosis is moderate. Anisocytosis is mild. A few mitoses are noted.
1713
Image ID:1713
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is diffuse hyperplasia of the mammary gland with mild to moderate diffuse lactation. In addition, at the center of the tissue, there is a small, encapsulated, densely cellular, expensile neoplastic nodule (glandular adenoma).
1715
Image ID:1715
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is diffuse hyperplasia of the mammary gland with mild to moderate diffuse lactation. In addition, at the center of the tissue, there is a small, encapsulated, densely cellular, expensile neoplastic nodule (early stage of a glandular adenoma).
1711
Image ID:1711
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29239 Mammary gland   hyperplasia - diffuse Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Hyperplasia, diffuse, with squamous metaplasia, mammary gland J:94320
Image Caption:Diffuse mammary gland hyperplasia: there is marked diffuse hyperplasia of the mammary gland. Cells often pile-up to 2 cells-thick in a few glands and ducts. Many epithelial cells contain lipid vacuoles and they occasionally contain proteinaceous droplets. A few cells have large nuclei (arrowhead). There is mild interstitial lymphocytic and plasmacytic inflammation.
1723
Image ID:1723
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is severe diffuse hyperplasia of the mammary gland. All mammary acini and ducts are lined by a cuboidal epithelium with lipid and proteinaceous secretion. Most of these structures are mildly ectatic and contain an inspissated proteinaceous material. A mammary duct is ectatic, shows prominent cornification, and is surrounded by mild fibrosis and interstitial lymphocytic and plasmacytic inflammation.
1721
Image ID:1721
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Diffuse mammary gland hyperplasia: there is marked diffuse hyperplasia of the mammary gland. Many epithelial cells contain lipid vacuoles and they occasionally contain proteinaceous droplets. There is moderate anisokaryosis. There is mild interstitial lymphocytic and plasmacytic inflammation.
1724
Image ID:1724
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is severe diffuse hyperplasia of the mammary gland. All mammary acini and ducts are lined by a cuboidal epithelium with lipid and proteinaceous secretion. Most of these structures are mildly ectatic and contain an inspissated proteinaceous material. A mammary duct is ectatic, shows prominent cornification, and is surrounded by mild fibrosis and interstitial lymphocytic and plasmacytic inflammation.
1720
Image ID:1720
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Ductal squamous metaplasia of the mammary gland: a mammary duct is ectatic, shows prominent cornification, and is surrounded by mild fibrosis and interstitial lymphocytic and plasmacytic inflammation.
1722
Image ID:1722
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29240 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, with prominent fibrosis and granulocytic inflammation, mammary gland J:94320
Image Caption:Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules lined by a one cell-thick cuboidal epithelium supported by an abundant amount of fibrovascular stroma. The stroma is infiltrated by a moderate number of granulocytes, lymphocytes and plasma cells. Neoplastic cells are cuboidal, medium-size, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often contains lipid vacuoles. The nucleus is basal, oval, medium-size to large, and generally hyperchromatic. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected.
1729
Image ID:1729
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules supported by an abundant amount of fibrovascular stroma.
1726
Image ID:1726
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where atypia is prominent and where a binucleated neoplastic cell is present.
1731
Image ID:1731
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules lined by a one cell-thick cuboidal epithelium supported by an abundant amount of fibrovascular stroma. The stroma is infiltrated by a moderate number of granulocytes, lymphocytes and plasma cells. Neoplastic cells are cuboidal, medium-size, with indistinct cell borders and a moderate amount of strongly acidophilic cytoplasm that often contains lipid vacuoles. The nucleus is basal, oval, medium-size to large, and generally hyperchromatic. Anisokaryosis and anisocytosis are moderate.
1728
Image ID:1728
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules lined by a one cell-thick cuboidal epithelium supported by an abundant amount of fibrovascular stroma. The stroma is infiltrated by a moderate number of granulocytes, lymphocytes and plasma cells.
1727
Image ID:1727
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where atypia is more prominent and where an asymmetrical mitosis is present.
1730
Image ID:1730
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a moderately to densely cellular neoplasm. This neoplasm is composed of glands and tubules supported by an abundant amount of fibrovascular stroma.
1725
Image ID:1725
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29241 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB-Tg(Trp53R172H)8512Jmr
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, glandular, mammary gland J:94320
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a predominantly solid portion of the neoplasm. A few secondary lumens are present. Mitotic rate is elevated. Some mitoses are asymmetrical.
1732
Image ID:1732
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the photomicrograph represents a portion of a densely cellular neoplasm. The neoplasm is composed of closely-packed lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are mostly composed of solid areas with the formation of a few secondary lumens.
1735
Image ID:1735
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the photomicrograph represents a portion of a densely cellular neoplasm. The neoplasm is composed of closely packed lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are mostly composed of solid areas with the formation of a few secondary lumens. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, medium-size, round to oval, and normochromatic. Anisocytosis and anisokaryosis are mild. Mitoses are numerous.
1736
Image ID:1736
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the photomicrograph represents a portion of a densely cellular neoplasm.
1733
Image ID:1733
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the photomicrograph represents a portion of a densely cellular neoplasm. The neoplasm is composed of closely-packed lobules separated by a scant amount of fibrovascular stroma.
1734
Image ID:1734
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates the morphology of a portion of the neoplasm with a solid phenotype. A few secondary lumens are present. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, medium-size, round to oval, and normochromatic. Anisocytosis and anisokaryosis are mild. Mitoses are numerous. There is no evidence of myoepithelial differentiation at the periphery of the neoplastic lobule.
1737
Image ID:1737
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29242 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, comedo, mammary gland J:94320
Image Caption:Mammary gland: neoplastic cells are medium-sized, with indistinct cell borders and a moderate amount of amphophilic to basophilic cytoplasm. The nucleus is central, oval, medium-size, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are very numerous and occasionally asymmetrical. There is mild fibrosis and pleocellular inflammation at the periphery of neoplastic nests.
1742
Image ID:1742
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by an invasive neoplasm characterized by the formation of large solid nests of neoplastic cells with various degrees of central necrosis and cavitation. Neoplastic cells are medium-sized, with indistinct cell borders and a moderate amount of amphophilic to basophilic cytoplasm. The nucleus is central, oval, medium-size, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are very numerous. There is mild fibrosis and pleocellular inflammation at the periphery of neoplastic nests.
1740
Image ID:1740
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, ill-defined, invasive, unencapsulated, densely cellular neoplasm. The neoplasm is composed of very thick trabeculae, solid areas and nests that invade the pre-existing mammary stroma. Prominent areas of cavitation are present at the center of the largest trabeculae and solid areas.
1738
Image ID:1738
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic cells are medium-sized, with indistinct cell borders and a moderate amount of amphophilic to basophilic cytoplasm. The nucleus is central, oval, medium-size, and slightly hypochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are very numerous and occasionally asymmetrical. There is mild fibrosis and pleocellular inflammation at the periphery of neoplastic nests.
1741
Image ID:1741
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, ill-defined, invasive, unencapsulated, densely cellular neoplasm. The neoplasm is composed of very thick trabeculae, solid areas and nests that invade the pre-existing mammary stroma. Prominent areas of cavitation are present at the center of the largest trabeculae and solid areas.
1739
Image ID:1739
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29266 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, trabecular, solid, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of closely-packed trabeculae that merge into solid areas and that are separated by a scant amount of fibrovascular stroma with a few entrapped adipocytes and a moderate lymphocytic and plasmacytic inflammation. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, normochromatic, and with a coarsely clumped chromatin. Anisokaryosis and anisocytosis are mild. Mitotic rate is very high.
1746
Image ID:1746
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed trabeculae that are 2-4 cells-thick at the periphery of the neoplasm, and up to 10 cells-thick at the center of the neoplasm. These trabeculae are separated by a scant amount of fibrovascular stroma and a moderate number of adipocytes have been entrapped in the neoplasm. A few tubules are present at the periphery of the neoplasm and are interpreted as non-neoplastic mammary tubules entrapped by the neoplasm. There is a moderate lymphocytic and plasmacytic inflammation at the periphery of the neoplasm.
1745
Image ID:1745
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed trabeculae that merge into solid areas and that are separated by a scant amount of fibrovascular stroma with a few entrapped adipocytes and a moderate lymphocytic and plasmacytic inflammation. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-sized, normochromatic, with a coarsely clumped chromatin and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is very high and a few asymmetrical mitoses are identified (arrowhead).
1747
Image ID:1747
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates the pattern of the neoplasm toward its' center. Neoplastic cells do not form lumens. A moderate number of adipocytes are entrapped within the neoplasm.
1748
Image ID:1748
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a nodular, densely cellular, well-delineated, invasive neoplasm. Areas of necrosis are present at the center of the neoplasm (at the bottom of this photomicrograph).
1743
Image ID:1743
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed trabeculae that are 2-4 cells-thick at the periphery of the neoplasm, and up to 10 cells-thick at the center of the neoplasm. These trabeculae are separated by a scant amount of fibrovascular stroma and a moderate number of adipocytes have been entrapped in the neoplasm.
1744
Image ID:1744
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29267 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, with prominent coagulation necrosis, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of closely-packed glands and branching ducts lined by a 1-2 cells-thick cuboidal epithelium and separated by a small amount of fibrovascular stroma. There are larg areas of coagulation necrosis.
1750
Image ID:1750
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of closely-packed glands. Approximately 60% of the neoplasm has undergone coagulation necrosis.
1749
Image ID:1749
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of closely-packed glands and branching ducts lined by a 1-2 cells-thick cuboidal epithelium and separated by a small amount of fibrovascular stroma. Some ducts are moderately ectatic and filled by a strongly acidophilic amorphous material and desquamated neoplastic cells. Neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round to oval, occasionally oriented in the long axis of the cell, medium-size, hyperchromatic, with a coarsely clumped chromatin and 1-4 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1752
Image ID:1752
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of closely-packed glands and branching ducts lined by a 1-2 cells-thick cuboidal epithelium and separated by a small amount of fibrovascular stroma. Some ducts are moderately ectatic and filled by a strongly acidophilic amorphous material and desquamated neoplastic cells. There are larg areas of coagulation necrosis.
1751
Image ID:1751
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29268 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, trabecular, solid, with prominent fibrosis and coagulation necrosis, mammary gland J:94320
Image Caption:Trabecular mammary adenocarcinoma: neoplastic cells form interconnected trabeculae that are 2-3 cells thick and that are separated by a moderate amount of fibrovascular stroma with a prominent pleocellular infiltrate. Neoplastic cells show prominent nuclear palissading at the periphery of the trabeculae. Luminal spaces are not detected. Neoplastic cells are cuboidal to low columnar, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is basal, oval, medium-size, normochromatic, with a punctate chromatin and 1-2 small basophilic nucleoli. Numerous areas of necrosis are present.
1757
Image ID:1757
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Trabecular mammary adenocarcinoma: neoplastic cells form interconnected trabeculae that are 2-3 cells thick and that are separated by a moderate amount of fibrovascular stroma with a prominent pleocellular infiltrate. Neoplastic cells show prominent nuclear palissading at the periphery of the trabeculae. Luminal spaces are not detected. Neoplastic cells are cuboidal to low columnar, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is basal, oval and medium-size. Numerous areas of necrosis are present.
1756
Image ID:1756
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Trabecular mammary adenocarcinoma: neoplastic cells form interconnected trabeculae that are 2-3 cells thick and that are separated by a moderate amount of fibrovascular stroma with a prominent pleocellular infiltrate. Neoplastic cells show prominent nuclear palissading at the periphery of the trabeculae. Luminal spaces are not detected. Neoplastic cells are cuboidal to low columnar, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is basal, oval, medium-size and normochromatic. There are numerous mitoses.
1755
Image ID:1755
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a densely cellular, unencapsulated, invasive neoplasm that invades the nearby muscles. The neoplasm is composed of interconnected trabeculae that are 2-3 cells-thick and that are separated by a moderate amount of dense fibrovascular stroma.
1754
Image ID:1754
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a densely cellular, unencapsulated, invasive neoplasm that invades the nearby muscles (arrowhead). There is a moderate pleocellular inflammatory infiltrate throughout the neoplasm. There are large areas of coagulation necrosis (*) at the center of the neoplasm.
1753
Image ID:1753
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Trabecular mammary adenocarcinoma: this photomicrograph illustrates an area of coagulation necrosis (at the center of the photomicrograph) and nuclear palissading at the periphery of the trabeculae (in the upper left corner of the photomicrograph). Neoplastic cells occasionally form small acini. Luminal spaces are not formed.
1758
Image ID:1758
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29269 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland J:94320
Image Caption:Solid mammary carcinoma: neoplastic lobules are composed of closely-packed cells and often show central areas of liquefactive necrosis (comedo pattern). There is prominent nuclear palissading at the periphery of neoplastic lobules. Neoplastic cells are medium-size, polygonal, with indistinct cell borders and a small amount of acidophilic cytoplasm. The nucleus is central, oval, normochromatic, and with a coarsely clumped chromatin. Anisokaryosis and anisocytosis are mild. There are numerous mitoses.
1762
Image ID:1762
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: neoplastic lobules are composed of closely-packed cells and often show central areas of liquefactive necrosis (comedo pattern). There is prominent nuclear palissading at the periphery of neoplastic lobules. Neoplastic cells are medium-size, polygonal, with indistinct cell borders and a small amount of acidophilic cytoplasm. The nucleus is central, oval, normochromatic, and with a coarsely clumped chromatin. Anisokaryosis and anisocytosis are mild. There are numerous mitoses.
1763
Image ID:1763
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Epithelial to mesenchymal transition in a solid carcinoma: this high magnification picture illustrates an area of epithelial to mesenchymal transition: neoplastic cells have an epithelial phenotype in the lower and lower right portions of the photomicrograph. The have a mesenchymal phenotype in the upper left portions of the photomicrograph. Concomitant with epithelial to mesenchymal transitions, the pattern of the neoplasm changes from a solid/trabecular pattern to a streaming/whirling pattern.
1765
Image ID:1765
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Epithelial to mesenchymal transition in a solid carcinoma: neoplastic cells form solid areas, are polygonal and have an epithelial phenotype in the lower right corner of the photomicrograph (E). Neoplastic cells are found as individual cells with a mesenchymal phenotypye embedded in a large amount of fibrovascular stroma in the upper left portions of the photomicrograph (M). Neoplastic cells are fusiform and form thick trabeculae in the area located between the area composed of epithelial neoplastic cells and the area composed of spindloid neoplastic cells.
1764
Image ID:1764
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a large mammary neoplasm composed of large lobules separated by thick fibrovascular septae. Numerous lobules are cavitated or have large central areas of liquefactive necrosis. An area of epithelial to mesenchymal transition (arrowhead) is present.
1759
Image ID:1759
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a portion of a large mammary neoplasm composed of large lobules separated by thick fibrovascular septae. Numerous lobules are cavitated or have large central areas of liquefactive necrosis.
1760
Image ID:1760
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: neoplastic lobules are composed of closely-packed cells and often show central areas of liquefactive necrosis (comedo pattern). There is prominent nuclear palissading at the periphery of neoplastic lobules.
1761
Image ID:1761
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29271 Mammary gland   adenocarcinoma - mixed Lung None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma of mammary origin, glandular, solid, comedo, metastatic to the lung J:94320
Image Caption:Lung: two small metastases of a mammary neoplasm are present in the lung. These neoplasm are associated with mild atelectasis of the adjacent pulmonary parenchyma.
1766
Image ID:1766
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a pulmonary metastasis of a mammary adenocarcinoma is composed of large lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are solid and neoplastic cells form numerous secondary lumens. Numerous large areas of liquefactive necrosis are present at the center of neoplastic lobules. There is prominent nuclear palissading at the periphery of neoplastic lobules.
1768
Image ID:1768
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a pulmonary metastasis of a mammary adenocarcinoma is composed of large lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are solid and neoplastic cells form secondary lumens (arrowheads). Numerous large areas of liquefactive necrosis are present at the center of neoplastic lobules. There is prominent nuclear palissading at the periphery of neoplastic lobules. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm that often contains a few small optically empty vacuoles (lipids?). The nucleus is central, oriented in the long axis of neoplastic cells, oval, medium-size and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1770
Image ID:1770
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a pulmonary metastasis of a mammary adenocarcinoma is composed of large lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are solid and neoplastic cells form numerous secondary lumens. Numerous large areas of liquefactive necrosis are present at the center of neoplastic lobules. There is prominent nuclear palissading at the periphery of neoplastic lobules. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm that often contains a few small optically empty vacuoles (lipids?). The nucleus is central, oriented in the long axis of neoplastic cells, oval, medium-size and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1769
Image ID:1769
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a pulmonary metastasis of a mammary adenocarcinoma is composed of large lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are solid and neoplastic cells form numerous secondary lumens. Numerous large areas of liquefactive necrosis are present at the center of neoplastic lobules. There is prominent nuclear palissading at the periphery of neoplastic lobules.
1767
Image ID:1767
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29273 Mammary gland   adenocarcinoma - solid Lung None (spontaneous)
NMRI-Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Mammary adenocarcinoma, solid, metastatic and embolic to the lungs J:94320
Image Caption:Lung: the photomicrograph represents a pulmonary metastasis of a mammary neoplasm. It is composed of small coalescing nests separated by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal, polygonal or oat-shaped, with ill-defined cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval, normochromatic, with a finely stippled chromatin and 1-5 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Numerous neoplastic cells undergo single cell necrosis, especially at the center of neoplastic nests.
1776
Image ID:1776
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: numerous nodular neoplasms are scattered throughout the pulmonary parenchyma. These nodules represent metastases of a mammary carcinoma. The metastases are composed of coalescing nests of various sizes. Secondary lumens are formed in some of these nests.
1774
Image ID:1774
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: the photomicrograph represents a pulmonary metastasis of a mammary neoplasm. There is prominent invasion of the media of a pulmonary artery by neoplastic cells (*). Mitoses are numerous.
1777
Image ID:1777
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: the photomicrograph represents a mammary neoplasm that has embolized in a pulmonary artery. The neoplasm has adhered to the wall of the blood vessel and has started to invade the intima and media of the artery. Mitoses and cells undergoing single cell necrosis are numerous. The center of the embolus has undergone liquefactive necrosis.
1778
Image ID:1778
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: numerous nodular neoplasms are scattered throughout the pulmonary parenchyma. These nodules represent metastases of a mammary carcinoma.
1771
Image ID:1771
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a pulmonary metastasis of a mammary neoplasm is present at the center of the photomicrograph. It is composed of small coalescing nests separated by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal, polygonal or oat-shaped, with ill-defined cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval, normochromatic, with a finely stippled chromatin and 1-5 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1775
Image ID:1775
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: numerous nodular neoplasms are scattered throughout the pulmonary parenchyma. These nodules represent metastases of a mammary carcinoma.
1773
Image ID:1773
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: numerous nodular neoplasms are scattered throughout the pulmonary parenchyma. These nodules represent metastases of a mammary carcinoma.
1772
Image ID:1772
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: the photomicrograph represents a mammary neoplasm that has embolized in a pulmonary artery. The neoplasm has adhered to the wall of the blood vessel and has started to invade the intima and media of the artery. Mitoses and cells undergoing single cell necrosis are numerous. The center of the embolus has undergone liquefactive necrosis.
1779
Image ID:1779
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29274 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Carcinoma in situ and atypical lobular hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph illustrates a duct that is distended by large globules of inspissated proteinaceous material. There is mild to moderate fibrosis in the adjacent connective tissue.
1785
Image ID:1785
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae.
1781
Image ID:1781
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae.
1780
Image ID:1780
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates acini where epithelial cells pile-up disorderly up to 3-4 cells-thick. Other changes consist in lipid vacuoles in the cytoplasm of a few epithelial cells, desquamated epithelial cells and macrophages intermingled with a proteinaceous material in the lumen of all acini and intralobular ducts, an elevated mitotic rate, and the presence of numerous epithelial cells undergoing single cell necrosis.
1788
Image ID:1788
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae. There is mild to moderate interstitial fibrosis and pleocellular inflammation.
1782
Image ID:1782
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a duct that is distended by large globules of inspissated proteinaceous material. The globules of inspissated proteinaceous material are surrounded by a one cell-thick layer of basket-shaped cells. There is mild to moderate fibrosis in the adjacent connective tissue.
1786
Image ID:1786
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates acini where epithelial cells pile-up disorderly up to 3-4 cells-thick. Other changes consist in lipid vacuoles in the cytoplasm of a few epithelial cells, desquamated epithelial cells and macrophages intermingled with a proteinaceous material in the lumen of all acini and intralobular ducts, an elevated mitotic rate, and the presence of numerous epithelial cells undergoing single cell necrosis.
1787
Image ID:1787
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium. In this field, epithelial cells often contain cytoplasmic lipid vacuoles.
1783
Image ID:1783
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium. In this field, epithelial cells often contain cytoplasmic lipid vacuoles. Mitoses are numerous.
1784
Image ID:1784
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29275 Mammary gland   hyperplasia - atypical - lobular Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Carcinoma in situ and atypical lobular hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae.
1781
Image ID:1781
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae.
1780
Image ID:1780
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates acini where epithelial cells pile-up disorderly up to 3-4 cells-thick. Other changes consist in lipid vacuoles in the cytoplasm of a few epithelial cells, desquamated epithelial cells and macrophages intermingled with a proteinaceous material in the lumen of all acini and intralobular ducts, an elevated mitotic rate, and the presence of numerous epithelial cells undergoing single cell necrosis.
1788
Image ID:1788
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium that occasionally forms minute papillae. There is mild to moderate interstitial fibrosis and pleocellular inflammation.
1782
Image ID:1782
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a duct that is distended by large globules of inspissated proteinaceous material. There is mild to moderate fibrosis in the adjacent connective tissue.
1785
Image ID:1785
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a duct that is distended by large globules of inspissated proteinaceous material. The globules of inspissated proteinaceous material are surrounded by a one cell-thick layer of basket-shaped cells. There is mild to moderate fibrosis in the adjacent connective tissue.
1786
Image ID:1786
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates acini where epithelial cells pile-up disorderly up to 3-4 cells-thick. Other changes consist in lipid vacuoles in the cytoplasm of a few epithelial cells, desquamated epithelial cells and macrophages intermingled with a proteinaceous material in the lumen of all acini and intralobular ducts, an elevated mitotic rate, and the presence of numerous epithelial cells undergoing single cell necrosis.
1787
Image ID:1787
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium. In this field, epithelial cells often contain cytoplasmic lipid vacuoles.
1783
Image ID:1783
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the overall architecture of the mammary gland is maintained. Most interlobular ducts and a few intralobular ducts are moderately distended by a proteinaceous material that contains a few desquamated epithelial clels and macrophages. All intralobular ducts and acini are hypercellular and lined by a 1-3 cells-thick epithelium. In this field, epithelial cells often contain cytoplasmic lipid vacuoles. Mitoses are numerous.
1784
Image ID:1784
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29276 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, solid, mammary gland J:94320
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the solid portions of the neoplasm. The center of this area has undergone liquefactive necrosis. This area is composed of nests and solid areas. Slender fibrovascular septae (arrwoheads) subdivide the solid areas. Numerous neoplastic cells undergo single cell necrosis and mitotic rate is high.
1796
Image ID:1796
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the papillary portions of the neoplasm. Neoplastic papillae have a slender fibrovascular core and are lined by a 2-15 cells-thick epithelium.
1791
Image ID:1791
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the solid portions of the neoplasm. The center of this area has undergone liquefactive necrosis. This area is composed of nests and solid areas. Slender fibrovascular septae subdivide the solid areas.
1795
Image ID:1795
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the papillary portions of the neoplasm. Neoplastic papillae have a slender fibrovascular core and are lined by a 2-15 cells-thick epithelium. Neoplastic cells are columnar to polygonal, with ill-defined cell borders and a small amount of amphophilic cytoplasm. The nucleus is oval to round, oriented in the long axis of the cell for columnar neoplastic cells, and slightly hyperchromatic. Numerous neoplastic cells undergo single cell necrosis and mitotic figures are numerous.
1792
Image ID:1792
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the solid portions of the neoplasm. The center of this solid area has undergone liquefactive necrosis.
1794
Image ID:1794
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph focuses on the papillary portions of the neoplasm. Neoplastic papillae have a slender fibrovascular core and are lined by a 2-15 cells-thick epithelium. Neoplastic cells are columnar (cells adherent to the basement membrane) to polygonal (suprabasal cells), with ill-defined cell borders and a small amount of amphophilic cytoplasm. The nucleus is oval to round, oriented in the long axis of the cell for columnar neoplastic cells, slightly hyperchromatic, and with a clumped chromatin. Numerous neoplastic cells undergo single cell necrosis and mitotic figures are numerous. Most mitoses are asymmetrical (the mitotic spindle is oriented at right angle with the basement membrane).
1793
Image ID:1793
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, nodular, well-delineated, encapsulated, densely cellular neoplasm that is comprised of papillary portions (lower portions of the neoplasm) and solid portions (upper portions of the neoplasm) with central liquefactive necrosis.
1790
Image ID:1790
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, nodular, well-delineated, encapsulated, densely cellular neoplasm that is comprised of papillary portions (lower portions of the neoplasm) and solid portions (upper portions of the neoplasm) with central liquefactive necrosis.
1789
Image ID:1789
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29277 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Ductal carcinoma in situ, mammary gland J:94320
Image Caption:Ductal carcinoma in situ: this photomicrograph illustrates the morphology of an interlobular duct that is distended by neoplastic cells. Neoplastic cells have not ruptured the basement membrane of the interlobular mammary duct.
1802
Image ID:1802
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is maintained. All the acini and intralobular ducts of a mammary lobule are filled with and slightly distended by solid masses of epithelial cells. There is moderate interstitial fibrosis and pleocellular inflammation. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. Numerous neoplastic cells undergo single cell necrosis.
1799
Image ID:1799
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is maintained. The interlobular duct leading to a mammary lobule, and all the acini and intralobular ducts of this mammary lobule are filled with and slightly distended by solid masses of epithelial cells. There is moderate interstitial fibrosis and pleocellular inflammation. The ducts and acini of adjacent mammary lobules are moderately distended by an inspissated proteinaceous fluid, are lined by a prominent epithelium, and are surrounded by mild to moderate fibrosis.
1797
Image ID:1797
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is maintained. The interlobular duct leading to a mammary lobule, and all the acini and intralobular ducts of a mammary lobule are filled with and slightly distended by solid masses of epithelial cells. There is moderate interstitial fibrosis and pleocellular inflammation. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. Numerous neoplastic cells undergo single cell necrosis.
1798
Image ID:1798
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Ductal carcinoma in situ: this photomicrograph illustrates the morphology of an interlobular duct that is distended by neoplastic cells. Neoplastic cells have not ruptured the basement membrane of the interlobular mammary duct. Numerous neoplastic cells undergo apoptosis. A few mitoses are noted. Also, at the center of the duct, there is a small cluster of large cells (arrowheads) with better defined cell borders and a more hypochromatic than nearby cells. These features are consistent with squamous metaplasia. Myoepithelial differentiation (arrow) is present.
1801
Image ID:1801
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Ductal carcinoma in situ: there is keratinization of individual neoplastic cells (arrowheads). These cells have angular contours, a more acidophilic cytoplasm, and a larger and more hypochromatic nucleus with a larger nucleolus than nearby neoplastic cells. The other neoplastic cells are polygonal, with indistinct cell borders, a small amount of dark amphophilic cytoplasm, and a medium-size, oval, hyperchromatic nucleus with a punctate chromatin. Anisokaryosis and anisocytosis are mild. Mitosis and neoplastic cells undergoing single cell necrosis are numerous.
1800
Image ID:1800
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29278 Mammary gland   hyperplasia - atypical - lobular Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Atypical lobular hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: the epithelium lining most acini is more prominent than normal. Most acini and ducts are mildly to moderately distended by an amorphous proteinaceous fluid. There is mild to moderate interstitial fibrosis. The mammary epithelium occasionally piles-up and shows moderate atypia. Numerous epithelial cells undergo apoptosis. A tripolar mitosis (arrowhead) is present.
1806
Image ID:1806
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the epithelium lining most acini and some ducts is more prominent than normal. Most acini and ducts are mildly to moderately distended by an amorphous proteinaceous fluid. There is mild to moderate interstitial fibrosis. The mammary epithelium occasionally piles-up and shows moderate atypia. Numerous epithelial cells undergo apoptosis.
1805
Image ID:1805
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobulation of the mammary gland is exaggerated. The epithelium lining most acini and some ducts is more prominent than normal. Most acini and ducts are mildly to moderately distended by an amorphous proteinaceous fluid. There is mild to moderate interstitial fibrosis.
1803
Image ID:1803
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the epithelium lining most acini and some ducts is more prominent than normal. Most acini and ducts are mildly to moderately distended by an amorphous proteinaceous fluid. There is mild to moderate interstitial fibrosis.
1804
Image ID:1804
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29279 Mammary gland   hyperplasia - atypical - lobular Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Atypical lobular hyperplasia, mammary gland J:94320
Image Caption:Atypical lobular hyperplasia: all alveoli are moderately ectatic, lined by a very prominent epithelium, and surrounded by mild to moderate interstitial fibrosis and pleocellular inflammation. Neoplastic cells seldom pile-up, and never pile-up more than 3 cells-thick.
1809
Image ID:1809
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobularity of the mammary gland is exagerated and there is moderate interstitial fibrosis. The epithelium lining most ducts and acini is prominent and the nucleo-cytoplasmic ration is elevated.
1808
Image ID:1808
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobularity of the mammary gland is exagerated and there is moderate interstitial fibrosis. The epithelium lining most ducts and acini is prominent and the nucleo-cytoplasmic ration is elevated.
1807
Image ID:1807
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Atypical lobular hyperplasia: mammary alveoli are lined by a one cell-thick low columnar epithelium with a few minute places where cells pile-up up to 2 cells-thick. The cells have a medium-size, oval, and hyperchromatic nucleus. Mitotic figures and apoptotic bodies are numerous. There is mild to moderate interstitial edema, with mild interstitial fibrosis and pleocellular inflammation.
1810
Image ID:1810
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29280 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
STOCK Tg(Wap-BCL2)#Jag Tg(Wap-Tag)8Gmn
 Female reproductive status not specified observed unknown Ductal carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: the lumen of the ducts and acini is moderately expanded by solid masses of epithelial cells. There is moderate interstitial fibrosis.
1812
Image ID:1812
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lumen of the ducts and acini is moderately expanded by solid masses of epithelial cells. There is moderate interstitial fibrosis. The cells are polygonal with ill-defined cell borders, a moderate amount of amphophilic cytoplasm, and a medium-size hyperchromatic nucleus. There are numerous mitotic figures.
1813
Image ID:1813
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lumen of the ducts and acini is moderately expanded by solid masses of epithelial cells. There is moderate interstitial fibrosis.
1811
Image ID:1811
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29281 Mammary gland   adenocarcinoma - trabecular Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri/J
 Female reproductive status not specified observed 240 days Adenocarcinoma, glandular and trabecular, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, well-delineated, locally invasive, and densely cellular neoplasm. This neoplasm is composed of glands and 3-6 cells-thick trabeculae supported by a moderate amount of fibrovascular stroma with a mild lymphocytic and plasmacytic inflammation. There is a moderate lymphocytic and plasmacytic inflammation at the periphery of the neoplasm.
1815
Image ID:1815
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of glands and 3-6 cells-thick trabeculae supported by a moderate amount of fibrovascular stroma with a mild lymphocytic and plasmacytic inflammation. Neoplastic cells are polygonal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic and with 1-3 medium-size to large amphophilic nucleoli. Anisocytosis and anisokaryosis are mild to moderate. Mitoses are numerous. Numerous neoplastic cells undergo apoptosis.
1817
Image ID:1817
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is locally invasive. It is composed of glands and 3-6 cells-thick trabeculae supported by a moderate amount of fibrovascular stroma with a mild lymphocytic and plasmacytic inflammation. Neoplastic cells are polygonal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic and with 1-3 medium-size to large amphophilic nucleoli. Anisocytosis and anisokaryosis are mild to moderate. Mitoses are numerous. Numerous neoplastic cells undergo apoptosis.
1816
Image ID:1816
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: two small neoplasms are present in the mammary gland. These neoplasms are nodular, well-delineated, locally invasive, and densely cellular.
1814
Image ID:1814
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29284 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri/J
 Female reproductive status not specified observed 240 days Adenocarcinoma, solid, glandular, with epithelial to mesenchymal transition, mammary gland J:94320
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph focuses on an area of epithelial to mesenchymal transition. A few glands lined by a one cell-thick cuboidal epithelium persist at the center of the area of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is characterized by neoplastic cells acquiring a spindloid to epithelioid phenotype and blending into the stroma. Cells that have undergone epithelial to mesenchymal transition have distinct cell borders and a moderate to large amount of strongly acidophilic cytoplasm. The nucleus is oval, normochromatic, and with 1-2 small basophilic nucleoli. Cells with an epithelial phenotype are polygonal, with indistinct cell borders, and a small to moderate amount of amphophilic cytoplasm. The nucleus is central, round, slightly hyperchromatic and with a punctate chromatin.
1822
Image ID:1822
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph focuses on an area of epithelial to mesenchymal transition. A few glands lined by a one cell-thick cuboidal epithelium persist at the center of the area of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is characterized by neoplastic cells acquiring a spindloid to epithelioid phenotype and blending into the stroma.
1820
Image ID:1820
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: large portions of the neoplasm in this field have a glandular (epithelial) pattern. However, epithelial to mesenchymal transition (*) is prominent in the upper right corner of the photomicrograph. The glandular portions are composed of small glands embedded in a small amount of fibrovascular stroma. The spindloid portions are composed of individual neoplastic cells, small packets and small bundles embedded in moderate amount of fibrovascular stroma.
1819
Image ID:1819
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph represents a portion of the neoplasm that predominantly is composed of neoplastic cells with an epithelial phenotype forming glands. In addition, there is an area of epithelial to mesenchymal transition (upper left corner of the photomicrograph). Neoplastic cells with a spindloid phenotype can hardly be differentiated from stromal cells.
1825
Image ID:1825
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, nodular, unencapsulated, densely cellular neoplasm with a prominent central area of necrosis and cavitation. Most of the neoplasm has an epithelial phenotype. However, large portions of the neoplasm (?40%) show areas of epithelial to mesenchymal transition (upper right portions of the neoplasm).
1818
Image ID:1818
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph represents a portion of the neoplasm that predominantly is composed of neoplastic cells with an epithelial phenotype forming glands. In addition, there is an area of epithelial to mesenchymal transition (*).
1823
Image ID:1823
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph focuses on an area of epithelial to mesenchymal transition. A few glands lined by a one cell-thick cuboidal epithelium persist at the center of the area of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is characterized by neoplastic cells acquiring a spindloid to epithelioid phenotype and blending into the stroma.
1821
Image ID:1821
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: this photomicrograph represents a portion of the neoplasm that predominantly is composed of neoplastic cells with an epithelial phenotype forming glands. In addition, there is an area of epithelial to mesenchymal transition (*).
1824
Image ID:1824
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29288 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri/J
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular and papillary, with prominent coagulation necrosis, mammary gland J:94320
Image Caption:Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae and glands supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm. Neoplastic cells form glands lined by a one cell-thick low columnar to cuboidal epithelium supported by a scant amount of fibrovascular stroma. Many neoplastic glands are dilated by desquamated and degenerated neoplastic cells. Neoplastic often pile-up disorderly up to 5 cells-thick. Neoplastic cells are cuboidal to columnar with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, and slightly hyperchromatic.
1830
Image ID:1830
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae and glands supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm. Neoplastic cells form glands lined by a one cell-thick low columnar to cuboidal epithelium supported by a scant amount of fibrovascular stroma. Many neoplastic glands are dilated by desquamated and degenerated neoplastic cells.
1828
Image ID:1828
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae and glands supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm. Neoplastic cells form glands lined by a one cell-thick low columnar to cuboidal epithelium supported by a scant amount of fibrovascular stroma. Many neoplastic glands are dilated by desquamated and degenerated neoplastic cells. Neoplastic often pile-up disorderly up to 5 cells-thick. Neoplastic cells are cuboidal to columnar with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, and slightly hyperchromatic. Numerous neoplastic cells undergo single cell necrosis.
1831
Image ID:1831
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a very large, unencapsulated, expensile, multilobular neoplastic mass. Most of the neoplasm has undergone coagulation necrosis and only the peripheral portions survive, as well as a few neoplastic glands at the vicinity of the blood vessels towards the center of the neoplasm.
1826
Image ID:1826
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed glands and papillae supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm.
1827
Image ID:1827
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae and glands supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm. Neoplastic cells form glands lined by a one cell-thick low columnar to cuboidal epithelium supported by a scant amount of fibrovascular stroma. Many neoplastic glands are dilated by desquamated and degenerated neoplastic cells. Neoplastic often pile-up disorderly up to 5 cells-thick. Neoplastic cells are cuboidal to columnar with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, and slightly hyperchromatic.
1829
Image ID:1829
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29290 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, comedo, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm. This neoplasm is composed of solid areas with central cavitation (comedo pattern). Areas suggestive of the early stages of epithelial to mesenchymal transition are present at the periphery of the neoplasm (arrowhead).
1834
Image ID:1834
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Central portions of the neoplasm (solid with early stage of pseudoglandular pattern): the neoplasm is composed of very thick coalescing trabeculae separated by a small amount of loose fibrovascular stroma. Numerous neoplastic cells undergo single cell necrosis which results into the formation of small punched-out areas in the neoplastic trabeculae, a pattern known as "pseudoglandular pattern". Mitotic rate is high.
1838
Image ID:1838
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Peripheral portions of the neoplasm (trabecular area): neoplastic cells form trabeculae, cords and occasionally glands with an inconspicuous lumen (*) separated by a small to moderate amount of fibrovascular stroma. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, round to oval, slightly hypochromatic, with a stippled chromatin and 1-3 large nuclei. Anisokaryosis is moderate. Anisocytosis is mild. Numerous neoplastic cells undergo single cell necrosis. A few mitoses are present.
1837
Image ID:1837
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of solid areas with central cavitation (comedo pattern, left portions of the photomicrograph) and solid areas (center of the photomicrograph). Neoplastic cells form trabeculae and become spindloid towards the periphery of the neoplasm. However, they do not form bundles and fascicles. Apoptosis is prominent in the solid portions of the neoplasm.
1835
Image ID:1835
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Central portions of the neoplasm (solid and comedo patterns): the neoplasm is composed of very thick coalescing trabeculae and nests separated by a small amount of loose fibrovascular stroma. Numerous neoplastic cells undergo single cell necrosis which results into the cavitation of the nests and trabeculae, a pattern known as the comedo pattern.
1839
Image ID:1839
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Peripheral portions of the neoplasm (solid/trabecular area): the neoplasm is composed of solid areas (left portions of the photomicrograph). Neoplastic cells form trabeculae and become spindloid towards the periphery of the neoplasm. However, they do not form bundles and fascicles. Apoptosis is prominent in the solid portions of the neoplasm.
1836
Image ID:1836
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm. This neoplasm is composed of solid areas with central cavitation (comedo pattern). Areas suggestive of the early stages of epithelial to mesenchymal transition are present at the periphery of the neoplasm (arrowhead).
1833
Image ID:1833
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm. This neoplasm is composed of solid areas with central cavitation (comedo pattern; towards the center). Areas suggestive of the early stages of epithelial to mesenchymal transition are present at the periphery of the neoplasm (arrowhead).
1832
Image ID:1832
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29295 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB.Cg-Tg(WapMyc)212Bri/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Solid mammary carcinoma: the neoplasm is composed of large solid areas supported by a scant amount of fibrovascular stroma. Numerous neoplastic cells undergo apoptosis. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-size, slightly hypochromatic, with a clumped chromatin and 1-3 large acidophilic nucleoli Anisokaryosis and anisocytosis are moderate. Mitoses are numerous. Many neoplastic cells undergo apoptosis.
1847
Image ID:1847
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: the neoplasm is composed of large solid areas supported by a scant amount of fibrovascular stroma. Numerous neoplastic cells undergo apoptosis. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-size and slightly hypochromatic. Mitoses are numerous. Many neoplastic cells undergo apoptosis.
1844
Image ID:1844
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, well-delineated, densely cellular neoplasm. Numerous small areas of necrosis and cavitation are scattered throughout the neoplasm. The neoplasm is mostly composed of solid areas supported by a small amount of fibrovascular stroma. However, the presence of numerous areas of cavitation confer a pseudoglandular pattern to the neoplasm.
1842
Image ID:1842
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, well-delineated, densely cellular neoplasm. Numerous small areas of necrosis and cavitation are scattered throughout the neoplasm.
1840
Image ID:1840
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: the neoplasm is composed of large solid areas supported by a scant amount of fibrovascular stroma. Numerous neoplastic cells undergo apoptosis.
1843
Image ID:1843
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: the neoplasm is composed of large solid areas supported by a scant amount of fibrovascular stroma. Numerous neoplastic cells undergo apoptosis. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-size, slightly hypochromatic, with a clumped chromatin and 1-3 large acidophilic nucleoli Anisokaryosis and anisocytosis are moderate. Mitoses are numerous. Many neoplastic cells undergo apoptosis.
1845
Image ID:1845
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, multilobular, well-delineated, densely cellular neoplasm. Numerous small areas of necrosis and cavitation are scattered throughout the neoplasm.
1841
Image ID:1841
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: the neoplasm is composed of large solid areas supported by a scant amount of fibrovascular stroma. Numerous neoplastic cells undergo apoptosis. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-size, slightly hypochromatic, with a clumped chromatin and 1-3 large acidophilic nucleoli Anisokaryosis and anisocytosis are moderate. Mitoses are numerous. Many neoplastic cells undergo apoptosis.
1846
Image ID:1846
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29296 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
STOCK Tg(MMTV-S100a4)507Oku
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, acinar, cystic, solid with secondary lumens, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph illustrates a cystic neoplastic lobule lined by a 5-10 cells thick epithelium that forms a few small secondary lumens. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small amount of strongly amphophilic cytoplasm. The nucleus is central, oval, normochromatic, with a clumped chromatin and occasionally a small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. A skeletal muscle fiber (M) is entrapped in the neoplasm.
1853
Image ID:1853
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents a portion of the neoplasm with an acinar pattern. There is mild multifocal lactational activity.
1855
Image ID:1855
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm that is cystic and presents a few papillary projections (upper right corner). The other portions of the neoplasm is composed of closely-packed glands.
1849
Image ID:1849
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is effaced by a multilobular, densely cellular, polycystic neoplasm.
1848
Image ID:1848
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates a cystic neoplastic lobule lined by a 5-10 cells thick epithelium that forms a few small secondary lumens. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small amount of strongly amphophilic cytoplasm. The nucleus is central, oval, and normochromatic. Mitoses are numerous.
1852
Image ID:1852
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents a portion of the neoplasm with an acinar pattern. There is mild multifocal lactational activity.
1854
Image ID:1854
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: at its' periphery, the neoplasm formed hollow frond-like structures that contained a proteinaceous fluid with a few degenerated neoplastic cells. In these areas, the basal layers of the neoplastic epithelium clearly showed nuclear palissading.
1857
Image ID:1857
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is effaced by a multilobular, densely cellular, polycystic neoplasm. The neoplasm is composed of coalescing lobules separated by thick fibrovascular septae. Neoplastic lobules are composed of closely-packed glands. Some of the glands are cystic and they are filled by a moderate amount of proteinaceous fluid.
1850
Image ID:1850
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of coalescing lobules separated by thick fibrovascular septae. The center of the lobules is generally cystic and occasionally contains tissues that have undergone coagulation necrosis and hemorrhage (*). Neoplastic lobules are composed of closely-packed glands generally lined by a one cell-thick cuboidal epithelium. Neoplastic cell occasionally pile-up disorderly (up to 4-5 cells-thick) but retain the ability to form secondary lumens.
1851
Image ID:1851
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: at its' periphery, the neoplasm formed hollow frond-like structures that contained a proteinaceous fluid with a few degenerated neoplastic cells. In these areas, the basal layers of the neoplastic epithelium clearly showed nuclear palissading. This type of nuclear palissading is reminiscent of myoepithelial differentiation that is observed in type P tumors. However, unlike type P tumors, this neoplasm does not display ductal differentiation nor areas of squamous differentiation.
1859
Image ID:1859
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents a portion of the neoplasm with an acinar pattern. There is mild multifocal lactational activity that is characterized by the presence of a small amount of proteinaceous fluid in the lumen of neoplastic acini.
1856
Image ID:1856
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: at its' periphery, the neoplasm formed hollow frond-like structures that contained a proteinaceous fluid with a few degenerated neoplastic cells. In these areas, the basal layers of the neoplastic epithelium clearly showed nuclear palissading. This type of nuclear palissading is reminiscent of myoepithelial differentiation that is observed in type P tumors. However, unlike type P tumors, this neoplasm does not display ductal differentiation nor areas of squamous differentiation.
1858
Image ID:1858
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29297 Mammary gland   carcinoma - adenosquamous Mammary gland None (spontaneous)
FVB/N-Tg(Mt1-Hgf)#Lmb
 Female reproductive status not specified observed unknown Carcinoma, adenosquamous, and squamous metaplasia, mammary gland J:94320
Image Caption:Mammary gland: hyperplasia, squamous metaplasia with the formation or large rafts of "ghost" epithelial cells, interstitial fibrosis, and interstitial lymphocytic and plasmacytic inflammation are prominent in this mammary lobule.
1864
Image ID:1864
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the granulomatous, lymphoplasmacytic and fibrosing inflammatory reaction associated with rupture of neoplastic glands and leakage of cornified debris in the panniculus. Multinucleated giant cells (arrowhead) of histiocytic origin surround some rafts of "ghost" epithelial cells.
1873
Image ID:1873
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma, glandular portions: this photomicrograph illustrates the glandular portions of an adenosquamous carcinoma. Epithelial cells contain prominent lipid vacuoles.
1871
Image ID:1871
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma, glandular portions: this photomicrograph illustrates the glandular portions of an adenosquamous carcinoma. Epithelial cells contain prominent lipid vacuoles. Keratinization results into the formation of keratin pearls (arrowhead).
1872
Image ID:1872
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple small (<1 mm in diameter) nodules are scattered throughout the mammary gland. The largest lobules are composed of glands packed with cornified debris and lined by a squamous epithelium.
1861
Image ID:1861
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph represents an area of squamous metaplasia with dysplasia (upper right portions of the photomicrograph) and an area of lobular hyperplasia of the mammary gland (at the center and in the lower right corner of the photomicrograph).
1863
Image ID:1863
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: the neoplasm is connected to a large interlobular duct (*). The neoplasm is multilobular, well-delineated, locally invasive, moderately cellular and contains large rafts of "ghost" epithelial cells (E) that are surrounded by a prominent granulomatous and sclerosing inflammation. Other portions of the neoplasm are composed of closely-packed glands (G).
1867
Image ID:1867
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: most of the mammary gland shows moderate lobular hyperplasia which is characterized by an increase in the number of mammary acini which are mildly ectatic (lower left corner of the photomicrograph). In addition, multifocally, entire lobules show squamous metaplasia of their epithelium (upper right corner of the photomicrograph). The acini in these areas are filled with large rafts of "ghost" epithelial cells and they often rupture, resulting in the formation of a foreign-body type granulomatous reaction. There is also moderate interstitial fibrosis and lymphoplasmacytic inflammation surrounding the mammary lobules that have undergone squamous metaplasia.
1862
Image ID:1862
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: hyperplasia, squamous metaplasia with the formation or large rafts of "ghost" epithelial cells, interstitial fibrosis, and interstitial lymphocytic and plasmacytic inflammation are prominent in this mammary lobule. In addition, a few neutrophils have transmigrated through the metaplastic mammary epithelium and are intermingled with the cornified debris that often expand the lumen of mammary acini.
1865
Image ID:1865
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple small (<1 mm in diameter) nodules are scattered throughout the mammary gland. All mammary lobules are prominent, indicating moderate diffuse mammary lobular hyperplasia.
1860
Image ID:1860
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the area of transition between the neoplasm and the interlobular duct (*).
1868
Image ID:1868
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph represents an adenosquamous carcinoma of the mammary gland. The neoplasm is connected to a large interlobular duct (*). The neoplasm is multilobular, well-delineated, locally invasive, moderately cellular and contains large rafts of "ghost" epithelial cells that are surrounded by a prominent granulomatous and sclerosing inflammation.
1866
Image ID:1866
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the area of transition between the neoplasm and the interlobular duct (*). There is prominent squamous metaplasia in the interlobular duct. Cornification is abrupt and results into the formation of large rafts of "ghost" epithelial cells.
1869
Image ID:1869
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Interlobular duct at the vicinity of an adenosquamous carcinoma: there is prominent squamous metaplasia in the interlobular duct. Cornification is abrupt and results into the formation of large rafts of "ghost" epithelial cells.
1870
Image ID:1870
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29298 Mammary gland   metaplasia - squamous Mammary gland None (spontaneous)
FVB/N-Tg(Mt1-Hgf)#Lmb
 Female reproductive status not specified observed unknown Carcinoma, adenosquamous, and squamous metaplasia, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph represents an area of squamous metaplasia with dysplasia (upper right portions of the photomicrograph) and an area of lobular hyperplasia of the mammary gland (at the center and in the lower right corner of the photomicrograph).
1863
Image ID:1863
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: hyperplasia, squamous metaplasia with the formation or large rafts of "ghost" epithelial cells, interstitial fibrosis, and interstitial lymphocytic and plasmacytic inflammation are prominent in this mammary lobule.
1864
Image ID:1864
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple small (<1 mm in diameter) nodules are scattered throughout the mammary gland. All mammary lobules are prominent, indicating moderate diffuse mammary lobular hyperplasia.
1860
Image ID:1860
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the area of transition between the neoplasm and the interlobular duct (*).
1868
Image ID:1868
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph represents an adenosquamous carcinoma of the mammary gland. The neoplasm is connected to a large interlobular duct (*). The neoplasm is multilobular, well-delineated, locally invasive, moderately cellular and contains large rafts of "ghost" epithelial cells that are surrounded by a prominent granulomatous and sclerosing inflammation.
1866
Image ID:1866
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the area of transition between the neoplasm and the interlobular duct (*). There is prominent squamous metaplasia in the interlobular duct. Cornification is abrupt and results into the formation of large rafts of "ghost" epithelial cells.
1869
Image ID:1869
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma, glandular portions: this photomicrograph illustrates the glandular portions of an adenosquamous carcinoma. Epithelial cells contain prominent lipid vacuoles. Keratinization results into the formation of keratin pearls (arrowhead).
1872
Image ID:1872
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: this photomicrograph illustrates the granulomatous, lymphoplasmacytic and fibrosing inflammatory reaction associated with rupture of neoplastic glands and leakage of cornified debris in the panniculus. Multinucleated giant cells (arrowhead) of histiocytic origin surround some rafts of "ghost" epithelial cells.
1873
Image ID:1873
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma, glandular portions: this photomicrograph illustrates the glandular portions of an adenosquamous carcinoma. Epithelial cells contain prominent lipid vacuoles.
1871
Image ID:1871
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: most of the mammary gland shows moderate lobular hyperplasia which is characterized by an increase in the number of mammary acini which are mildly ectatic (lower left corner of the photomicrograph). In addition, multifocally, entire lobules show squamous metaplasia of their epithelium (upper right corner of the photomicrograph). The acini in these areas are filled with large rafts of "ghost" epithelial cells and they often rupture, resulting in the formation of a foreign-body type granulomatous reaction. There is also moderate interstitial fibrosis and lymphoplasmacytic inflammation surrounding the mammary lobules that have undergone squamous metaplasia.
1862
Image ID:1862
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Interlobular duct at the vicinity of an adenosquamous carcinoma: there is prominent squamous metaplasia in the interlobular duct. Cornification is abrupt and results into the formation of large rafts of "ghost" epithelial cells.
1870
Image ID:1870
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: hyperplasia, squamous metaplasia with the formation or large rafts of "ghost" epithelial cells, interstitial fibrosis, and interstitial lymphocytic and plasmacytic inflammation are prominent in this mammary lobule. In addition, a few neutrophils have transmigrated through the metaplastic mammary epithelium and are intermingled with the cornified debris that often expand the lumen of mammary acini.
1865
Image ID:1865
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Adenosquamous carcinoma: the neoplasm is connected to a large interlobular duct (*). The neoplasm is multilobular, well-delineated, locally invasive, moderately cellular and contains large rafts of "ghost" epithelial cells (E) that are surrounded by a prominent granulomatous and sclerosing inflammation. Other portions of the neoplasm are composed of closely-packed glands (G).
1867
Image ID:1867
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple small (<1 mm in diameter) nodules are scattered throughout the mammary gland. The largest lobules are composed of glands packed with cornified debris and lined by a squamous epithelium.
1861
Image ID:1861
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29299 Mammary gland   hyperplasia - lobular Mammary gland None (spontaneous)
FVB/N-Tg(Mt1-Hgf)#Lmb
 Female reproductive status not specified observed unknown Lobular hyperplasia and pigmentation, mammary gland J:94320
Image Caption:Mammary gland: the lobular architecture of the mammary gland is prominent.
1874
Image ID:1874
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobular architecture of the mammary gland is prominent. Large amounts of a golden-yellow and coarsely granular intracytoplasmic pigment are present in cells located within the epithelium or in the lumen of the mammary ducts and acini. This pigment most likely is located in macrophages rather than in epithelial cells.
1875
Image ID:1875
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29305 Mammary gland   carcinoma - spindle cell Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)#Sym
 Female reproductive status not specified observed unknown Carcinoma, spindle cell, with epithelial areas, mammary gland J:94320
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates an epithelial area. As exemplified on this photomicrograph, cornification may be observed in neoplasms undergoing epithelial to mesenchymal transition. Cornification is characterized by neoplastic cells acquiring a more abundant and more acidophilic cytoplasm as well as more angular contours. Their nucleus is larger, more hypochromatic, and with a larger nucleolus than other neoplastic cells.
1894
Image ID:1894
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates the presence of a few cells with an epithelial phenotype entrapped in a area that is otherwise exclusively composed of cells with a mesenchymal phenotype.
1886
Image ID:1886
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates an epithelial area. As exemplified on this photomicrograph, cornification may be observed in neoplasms undergoing epithelial to mesenchymal transition. Cornification is characterized by neoplastic cells acquiring a more abundant and more acidophilic cytoplasm as well as more angular contours. Their nucleus is larger, more hypochromatic, and with a larger nucleolus than other neoplastic cells.
1893
Image ID:1893
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates the presence of a few cells with an epithelial phenotype entrapped in a area that is otherwise exclusively composed of cells with a mesenchymal phenotype. There is gradual transition between the cells with the epithelial phenotype and the cells with the mesenchymal phenotype.
1887
Image ID:1887
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates an epithelial area. As exemplified on this photomicrograph, cornification may be observed in neoplasms undergoing epithelial to mesenchymal transition. Cornification is characterized by neoplastic cells acquiring a more abundant and more acidophilic cytoplasm as well as more angular contours. Their nucleus is larger, more hypochromatic, and with a larger nucleolus than other neoplastic cells.
1891
Image ID:1891
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates the presence of a few cells with an epithelial phenotype entrapped in a area that is otherwise exclusively composed of cells with a mesenchymal phenotype. There is gradual transition between the cells with the epithelial phenotype and the cells with the mesenchymal phenotype.
1888
Image ID:1888
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: in addition to skeletal muscle fibers, a few adipocytes have been entrapped in the neoplasm. The adipocytes appear as optically-empty round vacuoles.
1889
Image ID:1889
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates an epithelial area. As exemplified on this photomicrograph, cornification may be observed in neoplasms undergoing epithelial to mesenchymal transition. Cornification is characterized by neoplastic cells acquiring a more abundant and more acidophilic cytoplasm as well as more angular contours. Their nucleus is larger, more hypochromatic, and with a larger nucleolus than other neoplastic cells.
1890
Image ID:1890
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this high magnification photomicrograph illustrates a portion of the neoplasm where neoplastic cells have an epithelial phenotype and form trabeculae and gradually transform into cells with a mesenchymal phenotype forming fascicles. Dilated sinusoidal vessels are present in this portion of the neoplasm.
1892
Image ID:1892
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates the presence of a few cells with an epithelial phenotype entrapped in a area that is otherwise exclusively composed of cells with a mesenchymal phenotype.
1885
Image ID:1885
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Spindle cell carcinoma: this photomicrograph illustrates the presence of a few cells with an epithelial phenotype entrapped in a area that is otherwise exclusively composed of cells with a mesenchymal phenotype.
1884
Image ID:1884
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is entirely effaced and greatly expanded by a nodular, well-delineated, densely cellular neoplasm. This neoplasm is predominantly composed of bundles and fascicles separated by a scant amount of fibrovascular stroma. A few epithelial areas (*) characterized by the formation of small nests and trabeculae persist at the periphery of the neoplasm.
1876
Image ID:1876
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is predominantly composed of bundles and fascicles separated by a scant amount of fibrovascular stroma. A few epithelial areas (*) characterized by the formation of small nests and trabeculae persist at the periphery of the neoplasm. A few fascicles of skeletal muscle fibers and individual skeletal muscle fibers (arrowheads) are entrapped in the neoplasm.
1878
Image ID:1878
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is predominantly composed of bundles and fascicles separated by a scant amount of fibrovascular stroma. A few epithelial areas characterized by the formation of small nests and trabeculae persist at the periphery of the neoplasm and there is gradual transition between the epithelial and the mesenchymal phenotype. Cells with an epithelial phenotype are polygonal with distinct cell borders, a moderate amount of strongly amphophilic cytoplasm, and a round to oval medium-size nucleus. Cells with a mesenchymal phenotype are spindloid, with distinct cell borders, a small to moderate amount of acidophilic cytoplasm, and an elongated hyperchromatic nucleus.
1879
Image ID:1879
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this high magnification microphotograph focuses on the cells with an mesenchymal phenotype. These cells are organized in fascicles oriented at right angle one with another, are spindloid to fusifrom, with distinct cell borders, a small to moderate amount of acidophilic cytoplasm, and an elongated hyperchromatic nucleus. A moderate number of skeletal muscle fibers is entrapped in the neoplasm.
1882
Image ID:1882
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is predominantly composed of bundles and fascicles separated by a scant amount of fibrovascular stroma. A few epithelial areas characterized by the formation of small nests and trabeculae persist at the periphery of the neoplasm and there is gradual transition between the epithelial and the mesenchymal phenotype. Cells with an epithelial phenotype are polygonal with distinct cell borders, a moderate amount of strongly amphophilic cytoplasm, and a round to oval medium-size nucleus. Cells with a mesenchymal phenotype are spindloid, with distinct cell borders, a small to moderate amount of acidophilic cytoplasm, and an elongated hyperchromatic nucleus. Numerous neoplastic cells undergo apoptosis.
1880
Image ID:1880
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this high magnification microphotograph focuses on the cells with an mesenchymal phenotype. These cells are organized in fascicles oriented at right angle one with another, are spindloid to fusifrom, with distinct cell borders, a small to moderate amount of acidophilic cytoplasm, and an elongated hyperchromatic nucleus. A moderate number of skeletal muscle fibers is entrapped in the neoplasm (arrowheads), and some are degenerated.
1883
Image ID:1883
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is entirely effaced and greatly expanded by a nodular, well-delineated, densely cellular neoplasm. This neoplasm is predominantly composed of bundles and fascicles separated by a scant amount of fibrovascular stroma. A few epithelial areas characterized by the formation of small nests and trabeculae persist at the periphery of the neoplasm.
1877
Image ID:1877
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this high magnification microphotograph focuses on the cells with an epithelial phenotype. These cells are organized in nests, are polygonal with distinct cell borders, a moderate amount of strongly amphophilic cytoplasm, and a round to oval medium-size nucleus. Numerous neoplastic cells undergo apoptosis.
1881
Image ID:1881
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29306 Mammary gland   adenoma - papillary Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)5Sym
 Female reproductive status not specified observed unknown Papillary adenoma, intraductal, mammary gland J:94320
Image Caption:Mammary gland: a mammary duct is markedly ectatic. It contains a large amount of strongly acidophilic proteinaceous fluid and a few slender papillary projections lined by a two cells-thick epithelium where neoplastic cells occasionally pile-up. The occurence of two layers of cells is consistent with myoepithelial and luminal differentiation of neoplastic cells (complex papillary adenoma). Similar smaller lesions are present in the nearby mammary parenchyma.
1895
Image ID:1895
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary duct is markedly ectatic. It contains a large amount of strongly acidophilic proteinaceous fluid and a few slender papillary projections lined by a two cells-thick epithelium where neoplastic cells occasionally pile-up. The occurence of two layers of cells is consistent with myoepithelial and luminal differentiation of neoplastic cells (complex papillary adenoma).
1898
Image ID:1898
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary duct is markedly ectatic. It contains a large amount of strongly acidophilic proteinaceous fluid and a few slender papillary projections lined by a two cells-thick epithelium where neoplastic cells occasionally pile-up. The occurence of two layers of cells is consistent with myoepithelial and luminal differentiation of neoplastic cells (complex papillary adenoma). Luminal neoplastic cells are cuboidal, small, with indistinct cell borders and a moderate amount of granular acidophilic cytoplasm. The nucleus is central, oval, medium-size and normochromatic. Basal neoplastic cells (arrowheads) are cuboidal, small, with indistinct cell borders, a scant amount of acidophilic cytoplasm and a small hyperchromatic nucleus. There is no evidence of atypia and mitotic rate is low.
1896
Image ID:1896
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary duct is markedly ectatic. It contains a large amount of strongly acidophilic proteinaceous fluid and a few slender papillary projections lined by a two cells-thick epithelium where neoplastic cells occasionally pile-up. The occurence of two layers of cells is consistent with myoepithelial and luminal differentiation of neoplastic cells (complex papillary adenoma). Luminal neoplastic cells are cuboidal, small, with indistinct cell borders and a moderate amount of granular acidophilic cytoplasm. The nucleus is central, oval, medium-size and normochromatic. Basal neoplastic cells (arrowheads) form discontinuous rows. They are cuboidal, small, with indistinct cell borders, a scant amount of acidophilic cytoplasm and a small hyperchromatic nucleus. There is no evidence of atypia and mitotic rate is low.
1897
Image ID:1897
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29307 Mammary gland   hyperplasia Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)5Sym
 Female reproductive status not specified observed unknown Intraductal hyperplasia, multicentric, marked, mammary gland J:94320
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts. These projections are composed of a slender papillary core covered by several layers of small spindloid cells with indistinct cell borders, a scant amount of acidophilic cytoplasm, and a small oval hyperchromatic nucleus. Covering these spindloid cells is a one cell-thick layer of cuboidal to low columnar luminal cells with ill-defined cell borders, a moderate amount of acidophilic cytoplasm, and a medium-size central hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are not detected. A few luminal cells contain lipid vacuoles. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1901
Image ID:1901
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct is moderately expanded by a cauliflower-like proliferative process characterized by the formation of slender fibrovascular cores that support two populations of cells. First, there is a 1-5 cells-thick layer of oat-shaped cells with indistinct cell borders, a small amount of pale acidophilic cytoplasm and a small hyperchromatic oval nucleus. Second, there is a one cell-thick layer of cuboidal to low columnar cells that form conspicuous lumens filled with an amorphous proteinaceous material. These cells have indistinct cell borders, a moderate amount of acidophilic cytoplasm and a medium-size, central, normochromatic nucleus with a clumped chromatin. A few mast cells are present in the periductal connective tissue. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1904
Image ID:1904
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts.
1900
Image ID:1900
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts.
1899
Image ID:1899
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct is moderately expanded by a cauliflower-like proliferative process characterized by the formation of slender fibrovascular cores that support two populations of cells. First, there is a 1-5 cells-thick layer of oat-shaped cells with indistinct cell borders, a small amount of pale acidophilic cytoplasm and a small hyperchromatic oval nucleus. Second, there is a one cell-thick layer of cuboidal to low columnar cells that form conspicuous lumens filled with an amorphous proteinaceous material. These cells have indistinct cell borders, a moderate amount of acidophilic cytoplasm and a medium-size, central, normochromatic nucleus with a clumped chromatin. A few mast cells are present in the periductal connective tissue. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1903
Image ID:1903
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct contains multiple coalescing small cauliflower-like projections. These projections are composed of a slender papillary core covered by several layers of small spindloid cells with indistinct cell borders, a scant amount of acidophilic cytoplasm, and a small oval hyperchromatic nucleus. Covering these spindloid cells is a one cell-thick layer of cuboidal to low columnar luminal cells with ill-defined cell borders, a moderate amount of acidophilic cytoplasm, and a medium-size central hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are not detected. A few cells with a luminal phenotype contain lipid vacuoles (arrowheads). The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1902
Image ID:1902
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29308 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)5Sym
 Female reproductive status not specified observed unknown Intraductal hyperplasia, multicentric, marked, mammary gland J:94320
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts.
1899
Image ID:1899
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct is moderately expanded by a cauliflower-like proliferative process characterized by the formation of slender fibrovascular cores that support two populations of cells. First, there is a 1-5 cells-thick layer of oat-shaped cells with indistinct cell borders, a small amount of pale acidophilic cytoplasm and a small hyperchromatic oval nucleus. Second, there is a one cell-thick layer of cuboidal to low columnar cells that form conspicuous lumens filled with an amorphous proteinaceous material. These cells have indistinct cell borders, a moderate amount of acidophilic cytoplasm and a medium-size, central, normochromatic nucleus with a clumped chromatin. A few mast cells are present in the periductal connective tissue. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1903
Image ID:1903
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded. The ductal portions of the lobule are prominent and surrounded by prominent sclerosis. Cells in the ducts pile-up disorderly up to 3 cells-thick. Cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of granular and strongly acidophilic cytoplasm. The nucleus is central, oval, medium-size, normochromatic, with a punctate chromatin and one small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1907
Image ID:1907
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts. These projections are composed of a slender papillary core covered by several layers of small spindloid cells with indistinct cell borders, a scant amount of acidophilic cytoplasm, and a small oval hyperchromatic nucleus. Covering these spindloid cells is a one cell-thick layer of cuboidal to low columnar luminal cells with ill-defined cell borders, a moderate amount of acidophilic cytoplasm, and a medium-size central hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are not detected. A few luminal cells contain lipid vacuoles. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1901
Image ID:1901
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded. The ductal portions of the lobule are prominent and surrounded by prominent sclerosis. The acini are hyperplastic and are surrounded by lesser sclerosis.
1905
Image ID:1905
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct contains multiple coalescing small cauliflower-like projections. These projections are composed of a slender papillary core covered by several layers of small spindloid cells with indistinct cell borders, a scant amount of acidophilic cytoplasm, and a small oval hyperchromatic nucleus. Covering these spindloid cells is a one cell-thick layer of cuboidal to low columnar luminal cells with ill-defined cell borders, a moderate amount of acidophilic cytoplasm, and a medium-size central hypochromatic nucleus. Anisokaryosis and anisocytosis are mild. Mitoses are not detected. A few cells with a luminal phenotype contain lipid vacuoles (arrowheads). The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1902
Image ID:1902
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the alveoli of a mammary lobule affected by ductal carcinoma in situ. There is moderate anisokaryosis. In contrast to the ducts where mitotic figures were prominent, mitoses are not found in the alveoli.
1909
Image ID:1909
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded. The ductal portions of the lobule are prominent and surrounded by prominent sclerosis. Cells in the ducts pile-up disorderly up to 3 cells-thick. Cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of granular and strongly acidophilic cytoplasm. The nucleus is central, oval, medium-size, normochromatic, with a punctate chromatin and one small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. Myoepithelial differentiation is prominent (arrows). There is a focal area of squamous differentiation (arrowhead).
1908
Image ID:1908
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an interlobular mammary duct is moderately expanded by a cauliflower-like proliferative process characterized by the formation of slender fibrovascular cores that support two populations of cells. First, there is a 1-5 cells-thick layer of oat-shaped cells with indistinct cell borders, a small amount of pale acidophilic cytoplasm and a small hyperchromatic oval nucleus. Second, there is a one cell-thick layer of cuboidal to low columnar cells that form conspicuous lumens filled with an amorphous proteinaceous material. These cells have indistinct cell borders, a moderate amount of acidophilic cytoplasm and a medium-size, central, normochromatic nucleus with a clumped chromatin. A few mast cells are present in the periductal connective tissue. The presence of two layers of cells indicates that the cell that gave rise to these lesions is not committed to the luminal or to the basal lineage, and hence these lesions may be categorized as "complex" lesions.
1904
Image ID:1904
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: almost all interlobular and intralobular mammary ducts contain multiple and often coalescing small cauliflower-like projections. There is no evidence of fibrosis or inflammation around these ducts.
1900
Image ID:1900
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded. The ductal portions of the lobule are prominent and surrounded by prominent sclerosis. The acini are hyperplastic and are surrounded by lesser sclerosis. Cells in the ducts pile-up disorderly up to 3 cells-thick.
1906
Image ID:1906
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29309 Mammary gland   adenocarcinoma - complex Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)21Sym
 Female reproductive status not specified observed unknown Adenocarcinoma, complex, mammary gland J:94320
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates the morphology of the neoplasm towards its' center. Large blood-filled vascular spaces are present. Neoplastic cells form nests and trabeculae that often undergo cystic degeneration and are supported by a moderate amount of loose fibrovascular stroma. There are two types of neoplastic cells: (1) there are large polygonal cells with a moderate amount of pale acidophilic cytoplasm and a large central hypochromatic round to oval nucleus; (2) there are small polygonal cells with a small amount of amphophilic cytoplasm and a small hyperchromatic oval nucleus. Cells intermediate between these two phenotypes are also present. Anisokaryosis and anisocytosis are mild. Mitoses are rare.
1917
Image ID:1917
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates an area of ductal differentiation. Neoplastic cells form a two cell-thick epithelium. Luminal cells are cuboidal. Basal cells are either attenuated with a morphology reminiscent of myoepithelial cells, or they are cuboidal. Anisokaryosis and anisocytosis are mild. Mitoses are rare.
1919
Image ID:1919
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, densely cellular neoplasm. This neoplasm is composed of solid trabeculae and nests (predominantly at the periphery of the neoplasm) and cystic ducts (predominantly at the center of the neoplasm) supported by a small amount of loose fibrovascular stroma with numerous blood-filled dilated vascular spaces.
1913
Image ID:1913
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates the morphology of the neoplasm towards its' center. Large blood-filled vascular spaces are present. Neoplastic cells form nests and trabeculae that often undergo cystic degeneration and are supported by a moderate amount of loose fibrovascular stroma. There are two types of neoplastic cells: (1) there are large polygonal cells with a moderate amount of pale acidophilic cytoplasm and a large central hypochromatic round to oval nucleus; (2) there are small polygonal cells with a small amount of amphophilic cytoplasm and a small hyperchromatic oval nucleus. Cells intermediate between these two phenotypes are also present.
1916
Image ID:1916
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, densely cellular neoplasm. This neoplasm is composed of solid trabeculae and nests (predominantly at the periphery of the neoplasm) and cystic ducts (predominantly at the center of the neoplasm) supported by a small amount of loose fibrovascular stroma with numerous blood-filled dilated vascular spaces.
1911
Image ID:1911
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates the morphology of the periphery of the neoplasm. The neoplasm in this area is composed of small nests, interconnected trabeculae, and areas of cystic degeneration separated by a moderate amount of loose fibrovascular stroma. There are two types of neoplastic cells: (1) there are large polygonal cells with a moderate amount of pale acidophilic cytoplasm and a large central hypochromatic round nucleus; (2) there are small polygonal cells with a small amount of amphophilic cytoplasm and a small hyperchromatic oval nucleus. Cells intermediate between these two phenotypes are also present.
1914
Image ID:1914
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, densely cellular neoplasm. This neoplasm is composed of solid trabeculae and nests (predominantly at the periphery of the neoplasm) and cystic ducts (predominantly at the center of the neoplasm) supported by a small amount of fibrovascular stroma with numerous blood-filled dilated vascular spaces.
1910
Image ID:1910
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates the morphology of the periphery of the neoplasm. The neoplasm in this area is composed of small nests, interconnected trabeculae, and areas of cystic degeneration separated by a moderate amount of loose fibrovascular stroma. There are two types of neoplastic cells: (1) there are large polygonal cells with a moderate amount of pale acidophilic cytoplasm and a large central hypochromatic round nucleus; (2) there are small polygonal cells with a small amount of amphophilic cytoplasm and a small hyperchromatic oval to coma-shaped nucleus. Cells intermediate between these two phenotypes are also present. The large cells resemble the large light cells of the developing mammary gland.
1915
Image ID:1915
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a large, densely cellular neoplasm. This neoplasm is composed of solid trabeculae and nests (predominantly at the periphery of the neoplasm) and cystic ducts (predominantly at the center of the neoplasm) supported by a small amount of loose fibrovascular stroma with numerous blood-filled dilated vascular spaces.
1912
Image ID:1912
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph illustrates the morphology of the neoplasm towards its' center. Large blood-filled vascular spaces are present. Neoplastic cells form nests and trabeculae that often undergo cystic degeneration and are supported by a moderate amount of loose fibrovascular stroma. There are two types of neoplastic cells: (1) there are large polygonal cells with a moderate amount of pale acidophilic cytoplasm and a large central hypochromatic round to oval nucleus; (2) there are small polygonal cells with a small amount of amphophilic cytoplasm and a small hyperchromatic oval nucleus. Cells intermediate between these two phenotypes are also present. Anisokaryosis and anisocytosis are mild. Mitoses are rare.
1918
Image ID:1918
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29310 Mammary gland   hyperplasia - atypical - lobular Mammary gland None (spontaneous)
CD-1-Tg(Wap-Mmp3)21Sym
 Female reproductive status not specified observed unknown Lobular hyperplasia, atypical, mammary gland J:94320
Image Caption:Atypical lobular hyperplasia: this high power photomicrograph illustrates an area of ductal differentiation (arrowheads) and an area of acinar differentiation (*). The myoepithelial layer is more prominent in the area of ductal differentiation than in the area of acinar differentiation. A few mitoses are noted.
1924
Image ID:1924
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is prominent increased lobulation of the mammary gland. There is marked ectasia of the interlobular ducts that are filled with a proteinaceous fluid. Acini and intralobular ducts connecting to the cystic interlobular ducts are hyperplastic and there is moderate interstitial fibrosis. The mammary gland recapitulates the morphology of the pubertal mammary gland, with the formation of fronds that rapidly differentiate into ducts.
1922
Image ID:1922
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is prominent increased lobulation of the mammary gland. There is marked ectasia of the ducts of a mammary lobule. Acini in this lobule are hyperplastic and there is moderate interstitial fibrosis.
1921
Image ID:1921
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Atypical lobular hyperplasia: the interlobular and intralobular ducts are lined by two types of cells: (1) a one cell-thick layer of attenuated to low cuboidal cells that are reminiscent of myoepithelial cells; (2) a 2-4 cells-thick layer of cuboidal to polygonal cells. The acini form nests that are composed of cells that are larger, with a more acidophilic cytoplasm, and a larger and more hypochromatic nucleus than cells that line the ducts. Central cavitation and the formation of small slit-like lumens are common in the acinar areas. There is moderate interstitial fibrosis with mild pleocellular inflammation.
1923
Image ID:1923
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is prominent increased lobulation of the mammary gland. There is marked ectasia of the ducts of a mammary lobule. Acini in this lobule are hyperplastic and there is moderate interstitial fibrosis.
1920
Image ID:1920
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Atypical lobular hyperplasia: this high power photomicrograph illustrates the formation of fronds at the end of the area of acinar differentiation. These areas resemble the terminal end bud of the pubertal mammary gland. A few mitoses are noted.
1925
Image ID:1925
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29311 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
STOCK Tg(MMTV-Myc)#Led Tg(Wap-BCL2)#Jag
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, secretory, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, multilobular, densely cellular neoplasm. The glandular pattern is obvious in the peripheral portions of the neoplasm, even at this low magnification. Numerous areas of liquefactive necrosis (*) are present at the center of the neoplasm.
1927
Image ID:1927
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, multilobular, densely cellular neoplasm.
1926
Image ID:1926
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands lined by a one cell-thick cuboidal epithelium. There are also a few solid areas with secondary lumens. Glands and secondary lumens show various degrees of ectasia, and some contain a small to moderate of amorphous acidophilic fluid and occasionally a few desquamated neoplastic cells. Neoplastic cells are cuboidal to polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles and hyaline droplets. The nucleus is central, medium-size to large, round to oval, slightly hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected. Neoplastic cells occasionally pile-up disorderly.
1930
Image ID:1930
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands lined by a one cell-thick cuboidal epithelium. There are also a few solid areas with secondary lumens. Glands and secondary lumens show various degrees of ectasia, and some contain a small to moderate of amorphous acidophilic fluid and occasionally a few desquamated neoplastic cells. Neoplastic cells are cuboidal to polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles and hyaline droplets. The nucleus is central, medium-size to large, round to oval, slightly hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected. Neoplastic cells occasionally pile-up disorderly.
1931
Image ID:1931
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands lined by a one cell-thick cuboidal epithelium. There are also a few solid areas with secondary lumens. Glands and secondary lumens show various degrees of ectasia, and some contain a small to moderate of amorphous acidophilic fluid and occasionally a few desquamated neoplastic cells. Neoplastic cells are cuboidal to polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles and hyaline droplets. The nucleus is central, medium-size to large, round to oval, slightly hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected. Neoplastic cells occasionally pile-up disorderly.
1929
Image ID:1929
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, multilobular, densely cellular neoplasm. The glandular pattern is obvious in the peripheral portions of the neoplasm, even at this low magnification. Neoplastic lobules are composed of closely packed glands lined by a one cell-thick cuboidal epithelium. There are also a few solid areas with the formation of secondary lumens (cribriform pattern). These is a scant amount of fibrovascular stroma.
1928
Image ID:1928
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29312 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
STOCK Tg(MMTV-Myc)#Led Tg(Wap-BCL2)#Jag
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, solid, cribriform, mammary gland J:94320
Image Caption:Mammary adenocarcinoma: this photomicrograph represents a portion of the inner portions of the neoplasm. A narrow rim of neoplastic cells survive around dilated blood vessels (V). The rest of the tissue has undergone necrosis.
1938
Image ID:1938
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: in the peripheral portions of the neoplasm, neoplastic cells form small glands supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to low columnar, occasionally polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few small lipid vacuoles. The nucleus is central, oval, medium-sized and generally hyperchromatic. Anisokaryosis and anisocytosis are mild.
1935
Image ID:1935
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: in the peripheral portions of the neoplasm, neoplastic cells form small glands supported by a scant amount of fibrovascular stroma.
1933
Image ID:1933
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: in the peripheral portions of the neoplasm, neoplastic cells form small glands supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to low columnar, occasionally polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few small lipid vacuoles. The nucleus is central, oval, medium-sized and generally hyperchromatic. Anisokaryosis and anisocytosis are mild. A few mitoses (arrowheads) are detected.
1936
Image ID:1936
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: in the peripheral portions of the neoplasm, neoplastic cells form small glands supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to low columnar, occasionally polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few small lipid vacuoles. The nucleus is central, oval, medium-sized and generally hyperchromatic. Anisokaryosis and anisocytosis are mild.
1934
Image ID:1934
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland neoplasm (portion of): the mammary gland is expanded by a nodular, well-delineated, multilobular, densely cellular neoplasm. Linear areas of liquefactive necrosis (*) are present at the center of the neoplasm and form a reticular pattern.
1932
Image ID:1932
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary adenocarcinoma: this photomicrograph represents a portion of the inner portions of the neoplasm. A narrow rim of neoplastic cells survive around dilated blood vessels (V). The rest of the tissue has undergone necrosis.
1937
Image ID:1937
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29313 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(MMTVneu)202Mul/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, mammary gland J:94320
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of closely-packed small polygonal cells that form solid areas supported by a scant amount of loose fibrovascular stroma. Many blood vessels within the stroma are moderately ectatic.
1941
Image ID:1941
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is entirely effaced by a densely cellular, expensile, unencapsulated, neoplasm. This neoplasm is composed of solid areas with multiple small foci of liquefactive necrosis.
1940
Image ID:1940
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is entirely effaced by a densely cellular, expensile, unencapsulated, neoplasm. This neoplasm is composed of solid areas with multiple small foci of liquefactive necrosis.
1939
Image ID:1939
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: the neoplasm is composed of closely-packed small polygonal cells that form solid areas supported by a scant amount of loose fibrovascular stroma. Many blood vessels within the stroma are moderately ectatic. Neoplastic cells are medium-sized to small, with indistinct cell borders and a small to moderate amount of strongly acidophilic cytoplasm. The nucleus is central, oval, medium-sized and hyperchromatic anisocytosis and anisokaryosis are mild.
1942
Image ID:1942
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29314 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, trabecular, glandular, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where glands predominate. Neoplastic cells are cuboidal to polygonal, with ill-defined cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is basal, medium-size, oval, and normochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
1948
Image ID:1948
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where nests predominate. Necrosis is present at the center of the largest nest. A moderate number of secondary lumens is present in the solid areas.
1950
Image ID:1950
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expensile, densely cellular neoplasm. The neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae.
1944
Image ID:1944
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where glands predominate. Neoplastic cells are cuboidal to polygonal, with ill-defined cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is basal, medium-size, oval, and normochromatic. Anisokaryosis and anisocytosis are mild.
1946
Image ID:1946
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where glands predominate. Neoplastic cells are cuboidal to polygonal, with ill-defined cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is basal, medium-size, oval, and normochromatic. Anisokaryosis and anisocytosis are mild.
1947
Image ID:1947
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where nests predominate. Necrosis is present at the center of the largest nest. A moderate number of secondary lumens is present in the solid areas (arrowheads).
1951
Image ID:1951
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expensile, densely cellular neoplasm. The neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae.
1945
Image ID:1945
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expensile, densely cellular neoplasm.
1943
Image ID:1943
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of nests, trabeculae, and glands separated by moderately thick fibrous septae. This photomicrograph focuses on an area where nests predominate. Necrosis is present at the center of the largest nest. A moderate number of secondary lumens is present in the solid areas.
1949
Image ID:1949
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29315 Mammary gland   hyperplasia - atypical Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Hyperplasia, atypical, mammary gland J:94320
Image Caption:Mammary gland: the lumen of mammary ducts (predominantly) and acini is moderately expanded by a strongly acidophilic proteinaceous material that also contains a few clusters of desquamated cells. The epithelium lining these ducts and acini is hypercellular and columnar and it forms a few minute papillary projections. Cells lining these ducts have a larger nucleus than what is expected for the normal mammary gland.
1954
Image ID:1954
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lumen of mammary ducts (predominantly) and acini is moderately expanded by a strongly acidophilic proteinaceous material that also contains a few clusters of desquamated cells. The epithelium lining these ducts and acini is hypercellular and columnar and it forms a few minute papillary projections.
1953
Image ID:1953
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lumen of mammary ducts (predominantly) and acini is moderately expanded by a strongly acidophilic proteinaceous material that also contains a few clusters of desquamated cells. The epithelium lining these ducts and acini is hypercellular and columnar.
1952
Image ID:1952
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29316 Mammary gland   carcinoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Spindle cell carcinoma arising in a glandular carcinoma, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of a few trabeculae and tubules interspersed among ill-defined bundles of neoplastic spindloid cells. There is gradual transition between some of the trabeculae and the spindloid cells.
1956
Image ID:1956
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of a few trabeculae and tubules interspersed among ill-defined bundles of neoplastic spindloid cells. There is gradual transition between some of the trabeculae and the spindloid cells. Neoplastic cells with an epithelial phenotype are polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm. Neoplastic cells with a mesenchymal phenotype are spindloid to oat-shaped, with distinct cell borders and a moderate amount of delicately fibrillar acidophilic cytoplasm and a slightly elongated hyperchromatic nucleus. The stroma is loose and edematous in the right portion of the photomicrograph, and dense and amorphous in the left portions of the photomicrograph.
1958
Image ID:1958
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of a few trabeculae and tubules interspersed among ill-defined bundles of neoplastic spindloid cells. There is gradual transition between some of the trabeculae and the spindloid cells. Neoplastic cells with an epithelial phenotype are polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm. Neoplastic cells with a mesenchymal phenotype are spindloid to oat-shaped, with distinct cell borders and a moderate amount of delicately fibrillar acidophilic cytoplasm and a slightly elongated hyperchromatic nucleus.
1957
Image ID:1957
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is focally expanded by a stellate, unencapsulated, ill-defined, invasive neoplasm. This neoplasm is composed of a few trabeculae and tubules interspersed among ill-defined bundles of neoplastic spindloid cells.
1955
Image ID:1955
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29317 Mammary gland   adenoma Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Adenoma, glandular, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplastic mass that has entrapped a moderate number of adipocytes. This mass is composed of glands supported by a small amount of fibrovascular stroma (some of which is pre-existing mammary connective tissue).
1959
Image ID:1959
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplastic mass that has entrapped a moderate number of adipocytes. This mass is composed of glands supported by a small amount of fibrovascular stroma (some of which is pre-existing mammary connective tissue).
1962
Image ID:1962
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a small, nodular, unencapsulated, densely cellular neoplastic mass that has entrapped a moderate number of adipocytes. This mass is composed of glands supported by a small amount of fibrovascular stroma (some of which is pre-existing mammary connective tissue).
1961
Image ID:1961
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplastic mass that has entrapped a moderate number of adipocytes. This mass is composed of glands supported by a small amount of fibrovascular stroma (some of which is pre-existing mammary connective tissue). The glands are contoured, anastomosed, with an inconspicuous lumen, and they are lined by a one cell-thick cuboidal to low columnar epithelium. Neoplastic cells have ill-defined cell borders, a moderate amount of strongly amphophilic cytoplasm, and a medium-size, oval, hyperchromatic nucleus oriented in the long axis of the neoplastic cell. Anisokaryosis and anisocytosis are minimal. A few mitoses are present.
1960
Image ID:1960
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29318 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
[not specified]-Tg(Wnt1)1Hev
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, glandular, complex, mammary gland J:94320
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma. The papillary pattern can be nicely appreciated at this magnification. Neoplastic papillae are massive and are lined by a two cells-thick cuboidal epithelium.
1967
Image ID:1967
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unenencapsulated, multilobular, densely cellular neoplasm. Neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma.
1964
Image ID:1964
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma. The papillary pattern can be nicely appreciated at this magnification. Many of the neoplastic glands are ectatic and contain a moderate amount of amorphous acidophilic fluid.
1965
Image ID:1965
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma. The papillary pattern can be nicely appreciated at this magnification. Neoplastic papillae are massive and are lined by a two cells-thick cuboidal epithelium.
1966
Image ID:1966
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unenencapsulated, multilobular, densely cellular neoplasm. Neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma.
1963
Image ID:1963
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma. The papillary pattern can be nicely appreciated at this magnification. Neoplastic papillae are massive and are lined by a two cells-thick cuboidal epithelium. The basal layer of cell is indicative of myoepithelial differentiation and is most easily identified in the papillary areas of the neoplasm (half lower right part of the photomicrographs), although it is also present in the glandular portions of the neoplasm (half upper left part of the photomicrograph). Anisokaryosis and anisocytosis are mild.
1968
Image ID:1968
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29319 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Fgf7)1Led
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, glandular, with squamous metaplasia and secretory activity, mammary gland J:94320
Image Caption:Papillary and glandular adenocarcinoma: the neoplasm is composed of glands in this area. Neoplastic cells ar ecuboidal to polygonal, with indistinct cell borders and a small to moderate amount of strongly acidophilic cytoplasm. The nucleus is central, medium-sized, oval and hyperchromatic. Anisokaryosis and anisocytosis are mild. There are numerous mitotic figures.
1972
Image ID:1972
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and glandular adenocarcinoma: the papillae and the glands are lined by a one cell-thick cuboidal to low columnar epithelium supported by a small amount of fibrovascular stroma. Neoplastic lobules are separated by thick fibrovascular septae.
1970
Image ID:1970
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph shows an area of transition between a papillary portion of the neoplasm (on the left) and of prominent squamous metaplasia (on the right). Squamous metaplasia results into the formation of large rafts of "ghost" cells.
1977
Image ID:1977
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and glandular adenocarcinoma: the papillae and the glands are lined by a one cell-thick cuboidal to low columnar epithelium supported by a small amount of fibrovascular stroma. Neoplastic lobules are separated by thick fibrovascular septae.
1971
Image ID:1971
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and glandular adenocarcinoma: this photomicrograph illustrates a papillary portion of the neoplasm. The papillae are lined by a one cell-thick cuboidal epithelium. Large ectatic blood vessels are present in the stroma.
1974
Image ID:1974
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, multilobular, unencapsulated, invasive, and densely cellular neoplasm. Neoplastic lobules are separated by thick fibrovascular septae and are composed of papillae (predominantly) and glands supported by a small amount of fibrovascular stroma.
1969
Image ID:1969
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and glandular adenocarcinoma: this photomicrograph illustrates a papillary portion of the neoplasm. The papillae are lined by a one cell-thick cuboidal epithelium. Large ectatic blood vessels are present in the stroma.
1976
Image ID:1976
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary and glandular adenocarcinoma: this photomicrograph illustrates an area of squamous metaplasia. Squamous metaplasia is abrupt and resembles keratinization in the hair follicle.
1975
Image ID:1975
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, multilobular, unencapsulated, invasive, and densely cellular neoplasm. Neoplastic lobules are separated by thick fibrovascular septae and are composed of papillae (predominantly) and glands supported by a small amount of fibrovascular stroma. Prominent lipid secretion is present in some portions of the neoplasm (*).
1973
Image ID:1973
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29320 Mammary gland   hyperplasia - alveolar/ductal Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Fgf7)1Led
 Female reproductive status not specified observed unknown Hyperplasia, ductal and alveolar, with squamous metaplasia, mammary gland J:94320
Image Caption:Papillary adenocarcinoma in an area of squamous metaplasia: squamous metaplasia results into the formation of large rafts of "ghost" cells.
1984
Image ID:1984
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly diffusely enlarged by hyperplastic acini and ducts. Cells in these areas do not pile-up and do not show atypia. In addition, there is prominent abrupt cornification (C) in the lumen of a moderate number of ducts and acini, resulting in the formation of large rafts of "ghost" cells.
1980
Image ID:1980
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenocarcinoma in an area of squamous metaplasia: squamous metaplasia results into the formation of large rafts of "ghost" cells.
1983
Image ID:1983
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is a diffuse expansion of the mammary gland by closely-packed glands and ducts the lumen of which often contains a small amount of proteinaceous fluid. A moderate number of epithelial cells contains lipid droplets. There is no evidence of atypia and cells do not pile-up disorderly.
1979
Image ID:1979
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplasia and squamous metaplasia, mammary gland: this photomicrograph illustrates an area of transition between an area of hyperplasia of the mammary gland (on the left) and an area of squamous metaplasia (on the right). A raft of ghost epithelial cells (*) and multinucleated epithelial cells (arrowhead) are present. A few nuclei have an apical location instead of a basal location, a feature consistent with dysplasia.
1982
Image ID:1982
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is a diffuse expansion of the mammary gland by closely-packed glands and ducts. A moderate number of epithelial cells contains lipid droplets. There is no evidence of atypia and cells do not pile-up disorderly.
1978
Image ID:1978
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly diffusely enlarged by hyperplastic acini and ducts. In addition, there is prominent abrupt cornification (C) in the lumen of a moderate number of ducts and acini, resulting in the formation of large rafts of "ghost" cells.
1985
Image ID:1985
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly diffusely enlarged by hyperplastic acini and ducts. Cells in these areas do not pile-up and do not show atypia. In addition, there is prominent abrupt cornification (C) in the lumen of a moderate number of ducts and acini, resulting in the formation of large rafts of "ghost" cells. There is a moderate interstitial lymphocytic and plasmacytic infiltration in the connective tissue surrounding the glands showing cornification.
1981
Image ID:1981
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29321 Mammary gland   carcinoma in situ Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Fgf7)1Led
 Female reproductive status not specified observed unknown Carcinoma in situ and hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is markedly diffusely enlarged by markedly hyperplastic acini and ducts. In adddition, there are multifocal areas of carcinoma in situ (*). These areas are characterized by epithelial cells piling-up in the ducts and acini, dilation of the lumen of the ducts and acini, and mild to moderate interstitial fibrosis. In addition, there is prominent abrupt cornification (C) in the lumen of a moderate number of ducts and acini, resulting in the formation of large rafts of "ghost" cells.
1986
Image ID:1986
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: most of the photomicrograph repesents an area of severe ductal and acinar hyperplasia. However, at the center of the photomicrograph, cells of mammary ducts pile-up, have larger nuclei than nearby cells, and there is moderate interstitial fibrosis.
1987
Image ID:1987
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: most of the photomicrograph repesents an area of severe ductal and acinar hyperplasia. However, at the center of the photomicrograph, cells of mammary ducts pile-up, have larger nuclei than nearby cells, and there is moderate interstitial fibrosis. The nucleus of a moderate number of cells has a luminal location and there is a moderate number of mitoses.
1988
Image ID:1988
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29322 Mammary gland   hyperplasia Mammary gland None (spontaneous)
FVB/N-Tg(MMTV-Fgf7)1Led
 Female reproductive status not specified observed unknown Carcinoma in situ and hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: most of the photomicrograph repesents an area of severe ductal and acinar hyperplasia. However, at the center of the photomicrograph, cells of mammary ducts pile-up, have larger nuclei than nearby cells, and there is moderate interstitial fibrosis.
1987
Image ID:1987
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: most of the photomicrograph repesents an area of severe ductal and acinar hyperplasia. However, at the center of the photomicrograph, cells of mammary ducts pile-up, have larger nuclei than nearby cells, and there is moderate interstitial fibrosis. The nucleus of a moderate number of cells has a luminal location and there is a moderate number of mitoses.
1988
Image ID:1988
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is markedly diffusely enlarged by markedly hyperplastic acini and ducts. In adddition, there are multifocal areas of carcinoma in situ (*). These areas are characterized by epithelial cells piling-up in the ducts and acini, dilation of the lumen of the ducts and acini, and mild to moderate interstitial fibrosis. In addition, there is prominent abrupt cornification (C) in the lumen of a moderate number of ducts and acini, resulting in the formation of large rafts of "ghost" cells.
1986
Image ID:1986
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29356 Mammary gland   tumor - type P Mammary gland None (spontaneous)
FVB-Tg(MMTV-Fgf3)NX1Mul
 Female reproductive status not specified observed unknown Type P tumor, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of cellular areas separated by thick strands of dense fibrovascular stroma. Epithelial areas are composed of microacini and papillary projections that have developed within the lumen of structures with a ductal morphology.
1990
Image ID:1990
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Type P tumor: in some portions of the neoplasm, neoplastic cells formed microacini filed with a a coagulated proteinaceous material. Neoplastic cells are small, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, round to oval, medium-sized, hyperchromatic and with a coarsely clumped chromatin. Anisocytosis and anisokaryosis are mild.
1993
Image ID:1993
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of cellular areas separated by thick strands of dense fibrovascular stroma. Epithelial areas are composed of microacini and papillary projections that have developed within the lumen of structures with a ductal morphology.
1989
Image ID:1989
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of cellular areas separated by thick strands of dense fibrovascular stroma. Epithelial areas are composed of microacini and papillary projections that have developed within the lumen of structures with a ductal morphology.
1991
Image ID:1991
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is replaced by a densely cellular neoplasm composed of cellular areas separated by thick strands of dense fibrovascular stroma. Epithelial areas are composed of microacini and papillary projections that have developed within the lumen of structures with a ductal morphology.
1994
Image ID:1994
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Type P tumor: a few large ducts lined by a pseudostratified epithelium are scattered throughout the neoplasm. Cells lining these ducts have a large amount of strongly acidophilic cytoplasm. Similar structures are also present in type P tumors which develop in mice transgenic for Wnt1.
1996
Image ID:1996
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland, type P tumor: in this portion of the neoplasm, neoplastic cells have formed large papillae. These papillae are lined, on their surface, by a two cell-thick epithelium resembling the mammary ductal epithelium which invaginates (arrowhead) to form terminal end bud-like structures (*).
1995
Image ID:1995
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Type P tumor: in some portions of the neoplasm, neoplastic cells formed microacini filed with a a coagulated proteinaceous material. Neoplastic cells are small, polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. Anisocytosis and anisokaryosis are mild.
1992
Image ID:1992
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29357 Mammary gland   tumor - type P Lung None (spontaneous)
FVB-Tg(MMTV-Fgf3)NX1Mul
 Female reproductive status not specified observed unknown Type P tumor, metastatic to the lung J:94320
Image Caption:Lung: there are multiple metastases of the type P mammary tumor. These metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts. Minute areas of cornification (arrowhead) are present in the areas of ductal differentiation.
2000
Image ID:2000
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: there are multiple metastases of the type P mammary tumor. These metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts.
1997
Image ID:1997
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: there are multiple metastases of the type P mammary tumor. These metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts.
1999
Image ID:1999
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: there are multiple metastases of the type P mammary tumor. These metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts.
2001
Image ID:2001
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: there are multiple metastases of the type P mammary tumor. These metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts.
1998
Image ID:1998
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: minute areas of cornification are present in the areas of ductal differentiation. Cells undergoing cornification often contain keratohyalin granules (basophilic granules) in their cytoplasm.
2003
Image ID:2003
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: the metastases share many features with the primary tumor, including the formation of microacini and of large papillary structures in ducts resembling the mammary ducts. Minute areas of cornification (arrowhead) are present in the areas of ductal differentiation. Cells undergoing cornification often contain keratohyalin granules (basophilic granules) in their cytoplasm.
2002
Image ID:2002
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29361 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
FVB/N-Tg(MtTPRMET)#Lng
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm with a prominent papillary pattern. The neoplasm is composed of closely-packed papillae lined by a one cell-thick cuboidal epithelium supported by a moderate amount of dense fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with ill-defined cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, and medium-size.
2006
Image ID:2006
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: this high power photomicrograph illustrates a portion at the periphery of the neoplasm where most of the neoplasm has a papillary pattern, although small clusters of cells invade the periphery of the neoplasm (arrowheads). Neoplastic cells become spindloid and form cords at the center of the photomicrograph. Numerous neoplastic cells undergo apoptosis.
2007
Image ID:2007
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm with a prominent papillary pattern. The neoplasm is composed of closely-packed papillae lined by a one cell-thick cuboidal epithelium supported by a moderate amount of dense fibrovascular stroma.
2004
Image ID:2004
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae lined by a one cell-thick cuboidal epithelium supported by a moderate amount of dense fibrovascular stroma. Neoplastic cells often pile-up disorderly. Neoplastic cells are cuboidal to polygonal, with ill-defined cell borders and a moderate amount of acidophilic cytoplasm that often contains lipid vacuoles. The nucleus is central, round, medium-size, normochromatic, with a clumped chromatin and 1-2 small (generally) to medium size bacophilic nucleoli. Anisokaryosis is moderate. Anisocytosis is mild. Numerous neoplastic cells undergo apoptosis. The stroma is fibrous.
2008
Image ID:2008
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, partly encapsulated, locally invasive, densely cellular neoplasm with a prominent papillary pattern. The neoplasm is composed of closely-packed papillae lined by a one cell-thick cuboidal epithelium supported by a moderate amount of dense fibrovascular stroma.
2005
Image ID:2005
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary mammary adenocarcinoma: this high power photomicrograph of the periphery of the neoplasm illustrates an area where neoplastic cells form small trabeculae and cords and become spindloid. The stroma is infiltrated by a moderate number of lymphocytes, plasma cells, and also mast cells (arrowheads).
2009
Image ID:2009
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29362 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, glandular, mammary gland J:94320
Image Caption:Mammary gland: this photomicrograph focuses on the center of the neoplasm where neoplastic cells form thick interconnected trabeculae that often show central liquefactive necrosis (comedo pattern). Although the pattern of the neoplasm is solid, there are numerous slit-like secondary lumens. There is a small to moderate amount of hyalinized fibrovascular stroma.
2016
Image ID:2016
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, well-delineated neoplasm. The neoplasm is composed of solid areas with central necrosis (comedo pattern) at the center of the neoplasm, with the gradual transition to small glandular structures are the periphery of the neoplasm. The stroma is more abundant and more fibrous at the periphery of the neoplasm than at its' center.
2010
Image ID:2010
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, well-delineated neoplasm. The neoplasm is composed of solid areas with central necrosis (comedo pattern) at the center of the neoplasm, with the gradual transition to small glandular structures are the periphery of the neoplasm. The solid areas often contain small slit-like lumens with angular contours that can be identified at this low magnification.
2011
Image ID:2011
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the periphery of the neoplasm where glandular differentiation is prominent. A few adipocytes are entrapped within the neoplasm. The central portions of the neoplasm are composed of large coalescing trabeculae with a few slit-like secondary lumens. The glands are lined by a one cell-thick cuboidal epithelium.
2013
Image ID:2013
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the periphery of the neoplasm where glandular differentiation is prominent. A few adipocytes are entrapped within the neoplasm. The glands are lined by a one cell-thick cuboidal epithelium where neoplastic cells often pile-up disorderly. Neoplastic cells have ill-defined cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, slightly hypochromatic, with a coarsely clumped chromatin and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
2014
Image ID:2014
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the center of the neoplasm where neoplastic cells form thick interconnected trabeculae that often show central liquefactive necrosis (comedo pattern). Although the pattern of the neoplasm is solid, there are numerous slit-like secondary lumens. There is a small to moderate amount of hyalinized fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, have ill-defined cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, oval, slightly hypochromatic, with a coarsely clumped chromatin and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.
2017
Image ID:2017
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the periphery of the neoplasm where glandular differentiation is prominent. A few adipocytes are entrapped within the neoplasm. The central portions of the neoplasm are composed of large coalescing trabeculae with a few slit-like secondary lumens. The glands are lined by a one cell-thick cuboidal epithelium.
2012
Image ID:2012
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph focuses on the center of the neoplasm where neoplastic cells form thick interconnected trabeculae that often show central liquefactive necrosis (comedo pattern). Although the pattern of the neoplasm is solid, there are numerous slit-like secondary lumens. There is a small to moderate amount of hyalinized fibrovascular stroma.
2015
Image ID:2015
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29363 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc Tg(Wap-TGFB1)6Lmb
 Female reproductive status not specified observed 330 days Adenocarcinoma, solid, with secondary lumens, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced and expanded by a large, nodular, encapsulated, well-delineated, densely cellular neoplasm. This neoplasm is composed of large (at the center of the neoplasm) to thin coalescing trabeculae supported by a moderate amount of hyalinized fibrovascular stroma.
2018
Image ID:2018
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced and expanded by a large, nodular, encapsulated, well-delineated, densely cellular neoplasm. This neoplasm is composed of large (at the center of the neoplasm) to thin coalescing trabeculae supported by a moderate amount of hyalinized fibrovascular stroma. Neoplastic cells form a few mildly ectatic glands at the periphery of the neoplasm.
2019
Image ID:2019
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a few secondary lumens are present in the trabeculae located at the periphery of the neoplasm.
2021
Image ID:2021
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced and expanded by a large, nodular, encapsulated, well-delineated, densely cellular neoplasm. This neoplasm is composed of coalescing trabeculae supported by a moderate amount of hyalinized fibrovascular stroma. This photomicrograph illustrates a portion of the neoplasm where a few glands are formed. Some glands are mildly ectatic. A few adipocytes have been entrapped in the neoplasm.
2020
Image ID:2020
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates the morphology of the center of the neoplasm. Neoplastic cells form thick trabeculae with occasional central liquefactive necrosis (comedo pattern). Neoplastic cells are medium-size, cuboidal to polygonal, with distinct cell borders, and a moderate amount of acidophilic cytoplasm. The nucleus is central, round to oval, and hyperchromatic. Anisokaryosis and anisocytosis are minimal.
2025
Image ID:2025
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates the morphology of the center of the neoplasm. Neoplastic cells form thick trabeculae with occasional central liquefactive necrosis (comedo pattern) and a few small secondary lumens.
2023
Image ID:2023
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this photomicrograph illustrates the morphology of the center of the neoplasm. Neoplastic cells form thick trabeculae with occasional central liquefactive necrosis (comedo pattern) and a few small secondary lumens. Neoplastic cells are medium-size, cuboidal to polygonal, with distinct cell borders, and a moderate amount of acidophilic cytoplasm. The nucleus is central, round to oval, and hyperchromatic. Anisokaryosis and anisocytosis are minimal.
2024
Image ID:2024
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a few secondary lumens are present in the trabeculae located at the periphery of the neoplasm. Neoplastic cells are medium-size, cuboidal to polygonal, with distinct cell borders, and a moderate amount of acidophilic cytoplasm. The nucleus is central, round to oval, and hyperchromatic. Anisokaryosis and anisocytosis are minimal.
2022
Image ID:2022
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29364 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(WapNotch4)10Rnc/J
 Female reproductive status not specified observed unknown Adenocarcinoma, solid, with secondary lumens, mamamry gland J:94320
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates an area of invasion in the mammary fat pad. The invasive portions of the neoplasm form small contoured and anastomosed glands with an inconspicuous lumen and they are surrounded by a mild scirrhous reaction. The center of some of the solid areas has undergone liquefactive necrosis (comedo pattern). Neoplastic cells are low columnar to polygonal, with indistinct cell borders and a moderate amout of acidophilic cytoplasm. The nucleus is basal, oval, medium-size, hypochromatic, and generally oriented in the long axis of the cell (at right angle with the basement membrane). Anisokaryosis and anisocytosis are mild. A few mitoses are present.
2031
Image ID:2031
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates an area of invasion in the mammary fat pad. The invasive portions of the neoplasm form small contoured and anastomosed glands with an inconspicuous lumen and they are surrounded by a mild scirrhous reaction. The center of some of the solid areas has undergone liquefactive necrosis (comedo pattern). Neoplastic cells are low columnar to polygonal, with indistinct cell borders and a moderate amout of acidophilic cytoplasm. The nucleus is basal, oval, medium-size, hypochromatic, and generally oriented in the long axis of the cell (at right angle with the basement membrane). Anisokaryosis and anisocytosis are mild. A few mitoses are present.
2032
Image ID:2032
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a solid mass of neoplastic cells is protruding in the lumen of an interlobular mammary duct.
2028
Image ID:2028
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a solid area of the neoplasm with central liquefactive necrosis (comedo pattern). The arrowheads point at secondary lumens.
2034
Image ID:2034
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a multilobular, partially encapsulated, locally invasive, densely cellular neoplasm which multifocally grows into the lumen of mammary ducts (arrowheads). The rest of the mammary gland is lactating.
2026
Image ID:2026
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates an area of invasion in the mammary fat pad. The invasive portions of the neoplasm form small contoured and anastomosed glands with an inconspicuous lumen and they are surrounded by a mild scirrhous reaction.
2030
Image ID:2030
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: this photomicrograph illustrates a solid area of the neoplasm with central liquefactive necrosis (comedo pattern).
2033
Image ID:2033
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a multilobular, partially encapsulated, locally invasive, densely cellular neoplasm which multifocally grows in the lumen of a duct. The neoplasm is composed of coalescing solid areas and trabeculae supported by a small to moderate amount of fibrovascular stroma. Secondary lumens are formed in some solid areas.
2027
Image ID:2027
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary adenocarcinoma: a solid mass of neoplastic cells is protruding in the lumen of an interlobular mammary duct.
2029
Image ID:2029
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29369 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Hyperplastic alveolar nodule, with squamous metaplasia, mammary gland J:94320
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia. There is also mild to moderate interstitial fibrosis and lymphocytic, plasmacytic and granulocytic inflammation. There is a focal area of squamous metaplasia with the formation of a keratin pearl (arrowhead).
2037
Image ID:2037
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: this photomicrograph illustrates an area of prominent secretory activity. There is no evidence of atypia. There is mild interstitial lymphocytic, plasmacytic and granulocytic inflammation. A few pigment-ladden macrophages are scattered in the stroma of the hyperplastic alveolar nodule.
2039
Image ID:2039
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia.
2035
Image ID:2035
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia. There is also mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation. There is a focal area of squamous metaplasia with the formation of a keratin pearl (arrowhead).
2036
Image ID:2036
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: this photomicrograph illustrates an area of squamous metaplasia. There is no evidence of atypia. Many luminal cells of the mammary gland contain lipid vacuoles. There is mild interstitial lymphocytic, plasmacytic and granulocytic inflammation.
2038
Image ID:2038
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29370 Mammary gland   metaplasia - squamous Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Hyperplastic alveolar nodule, with squamous metaplasia, mammary gland J:94320
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia. There is also mild to moderate interstitial fibrosis and lymphocytic, plasmacytic and granulocytic inflammation. There is a focal area of squamous metaplasia with the formation of a keratin pearl (arrowhead).
2037
Image ID:2037
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia.
2035
Image ID:2035
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is greatly expanded as a result of marked proliferation of its' epithelium and ductal and alveolar ectasia. There is also mild to moderate interstitial fibrosis and lymphocytic and plasmacytic inflammation. There is a focal area of squamous metaplasia with the formation of a keratin pearl (arrowhead).
2036
Image ID:2036
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: this photomicrograph illustrates an area of prominent secretory activity. There is no evidence of atypia. There is mild interstitial lymphocytic, plasmacytic and granulocytic inflammation. A few pigment-ladden macrophages are scattered in the stroma of the hyperplastic alveolar nodule.
2039
Image ID:2039
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Hyperplastic alveolar nodule: this photomicrograph illustrates an area of squamous metaplasia. There is no evidence of atypia. Many luminal cells of the mammary gland contain lipid vacuoles. There is mild interstitial lymphocytic, plasmacytic and granulocytic inflammation.
2038
Image ID:2038
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29371 Mammary gland   adenoma - tubular Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Adenoma, tubular, arising in an hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Mammary gland: there is, within an hyperplastic alveolar nodule, a small, densely cellular, unencapsulated, expensile, neoplasm (arrowheads). This neoplasm is composed of closely-packed tubules and solid areas supported by a scant amount of fibrovascular stroma.
2040
Image ID:2040
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Tubular adenoma of the mammary gland: the neoplasm is composed of closely packed tubules and solid areas supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, round, normochromatic, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
2042
Image ID:2042
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is, within an hyperplastic alveolar nodule, a small, densely cellular, unencapsulated, expensile, neoplasm (arrowheads). This neoplasm is composed of closely packed tubules and solid areas supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, round, normochromatic, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. A few mitoses are present (arrowheads). A small to moderate number of inflammatory cells, including pigment-laden macrophages, infiltrates the connective tissue in the hyperplastic alveolar nodule.
2041
Image ID:2041
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29372 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Adenoma, tubular, arising in an hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Mammary gland: there is, within an hyperplastic alveolar nodule, a small, densely cellular, unencapsulated, expensile, neoplasm (arrowheads). This neoplasm is composed of closely-packed tubules and solid areas supported by a scant amount of fibrovascular stroma.
2040
Image ID:2040
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Tubular adenoma of the mammary gland: the neoplasm is composed of closely packed tubules and solid areas supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, round, normochromatic, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. A few mitoses are present.
2042
Image ID:2042
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is, within an hyperplastic alveolar nodule, a small, densely cellular, unencapsulated, expensile, neoplasm (arrowheads). This neoplasm is composed of closely packed tubules and solid areas supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of homogeneous acidophilic cytoplasm. The nucleus is central, round, normochromatic, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis are mild. A few mitoses are present (arrowheads). A small to moderate number of inflammatory cells, including pigment-laden macrophages, infiltrates the connective tissue in the hyperplastic alveolar nodule.
2041
Image ID:2041
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29373 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Mammary gland: a mammary lobule is markedly hyperplastic. All alveoli are ectatic and contain a moderate amount of proteinaceous material. They are lined by a prominent cuboidal epithelium. There is mild to moderate interstitial fibrosis with moderate pleocellular inflammation.
2043
Image ID:2043
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland, hyperplastic alveolar nodule: all alveoli are ectatic and contain a moderate amount of proteinaceous material. They are lined by a prominent one cell-thick cuboidal epithelium. These cells often contain lipid vacuoles of various sizes. There is no evidence of atypia. There is mild interstitial fibrosis with moderate pleocellular inflammation.
2046
Image ID:2046
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland, hyperplastic alveolar nodule: all alveoli are ectatic and contain a moderate amount of proteinaceous material. They are lined by a prominent one cell-thick cuboidal epithelium. These cells often contain lipid vacuoles of various sizes. There is no evidence of atypia. There is mild interstitial fibrosis with moderate pleocellular inflammation.
2045
Image ID:2045
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland, hyperplastic alveolar nodule: all acini are ectatic and contain a moderate amount of proteinaceous material. They are lined by a prominent one cell-thick cuboidal epithelium. These cells often contain lipid vacuoles of various sizes and also a fw proteinaceous droplets. There is no evidence of atypia. There is mild interstitial fibrosis with moderate pleocellular inflammation.
2047
Image ID:2047
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is markedly hyperplastic. All alveoli are ectatic and contain a moderate amount of proteinaceous material. They are lined by a prominent cuboidal epithelium. There is mild to moderate interstitial fibrosis with moderate pleocellular inflammation. In addition, a small adenoma (*) is present.
2044
Image ID:2044
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29374 Mammary gland   adenoma - mixed Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Adenoma, solid and tubular, arising in an hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates a peripheral portion of the neoplasm where there is a small group of large cells that are columnar and have a more abundant and more acidophilic cytoplasm than most neoplastic cells. The other neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round, normochromatic, round, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis overall are mild. Mitoses are numerous.
2050
Image ID:2050
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates a peripheral portion of the neoplasm where there is a small group of large cells that are columnar and have a more abundant and more acidophilic cytoplasm than most neoplastic cells. These cells undergo squamous metaplasia (*) that is not associated with the presence of trichohyalin or keratohyalin granules. The other neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round, normochromatic, round, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis overall are mild. Mitoses are numerous.
2051
Image ID:2051
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a small, unenencapsulated, densely cellular, expensile neoplasm arising in an hyperplastic alveolar nodule. The neoplasm is composed of solid areas with secondary lumen and a few closely-packed glands that are lined by a one cell-thick cuboidal epithelium and are supported by a scant amount of fibrovascular stroma. Epithelial cells in the hyperplastic alveolar nodule (in the right and lower right portions of the photomicrograph) show more atypia than generally observed in typical hyperplastic alveolar nodules. Also, the contours of the alveoli in the hyperplastic alveolar nodule are more irregular than typically observed in an hyperplastic alveolar nodule. However, cells do not pile-up disorderly and the overall pattern of the normal mammary gland can still be identified.
2049
Image ID:2049
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates an area of transition between the hyperplastic alveolar nodule (to the far right) and the adenoma (to the left).
2052
Image ID:2052
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a small, unenencapsulated, densely cellular, expensile neoplasm arising in an hyperplastic alveolar nodule.
2048
Image ID:2048
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates an area of transition between the hyperplastic alveolar nodule (to the far right) and the adenoma (to the left). In the tumor, cells form solid areas with secondary lumens while the epithelium is one cell-thick in the hyperplastic alveolar nodule.
2053
Image ID:2053
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29375 Mammary gland   hyperplasia - alveolar Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Adenoma, solid and tubular, arising in an hyperplastic alveolar nodule, mammary gland J:94320
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates a peripheral portion of the neoplasm where there is a small group of large cells that are columnar and have a more abundant and more acidophilic cytoplasm than most neoplastic cells. These cells undergo squamous metaplasia (*) that is not associated with the presence of trichohyalin or keratohyalin granules. The other neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round, normochromatic, round, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis overall are mild. Mitoses are numerous.
2051
Image ID:2051
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates an area of transition between the hyperplastic alveolar nodule (to the far right) and the adenoma (to the left).
2052
Image ID:2052
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates an area of transition between the hyperplastic alveolar nodule (to the far right) and the adenoma (to the left). In the tumor, cells form solid areas with secondary lumens while the epithelium is one cell-thick in the hyperplastic alveolar nodule.
2053
Image ID:2053
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and tubular adenoma of the mammary gland: this photomicrograph illustrates a peripheral portion of the neoplasm where there is a small group of large cells that are columnar and have a more abundant and more acidophilic cytoplasm than most neoplastic cells. The other neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round, normochromatic, round, and with a small basophilic nucleolus. Anisokaryosis and anisocytosis overall are mild. Mitoses are numerous.
2050
Image ID:2050
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a small, unenencapsulated, densely cellular, expensile neoplasm arising in an hyperplastic alveolar nodule.
2048
Image ID:2048
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a small, unenencapsulated, densely cellular, expensile neoplasm arising in an hyperplastic alveolar nodule. The neoplasm is composed of solid areas with secondary lumen and a few closely-packed glands that are lined by a one cell-thick cuboidal epithelium and are supported by a scant amount of fibrovascular stroma. Epithelial cells in the hyperplastic alveolar nodule (in the right and lower right portions of the photomicrograph) show more atypia than generally observed in typical hyperplastic alveolar nodules. Also, the contours of the alveoli in the hyperplastic alveolar nodule are more irregular than typically observed in an hyperplastic alveolar nodule. However, cells do not pile-up disorderly and the overall pattern of the normal mammary gland can still be identified.
2049
Image ID:2049
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29376 Mammary gland   adenoma - papillary Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Papilloma, intraductal, with early transformation into a carcinoma, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplasm that arises within a duct (the duct was cut open during the preparation of the specimen). The lumen of the duct is filled with multiple papillary projections supported by delicate fibrovascular projections. Numerous hyperplastic alveolar nodules are present in the nearby mammary parenchyma.
2055
Image ID:2055
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma, area of early transformation into a carcinoma: neoplastic cells at the center of the photomicrograph are larger, have a paler cytoplasm, a larger and paler nucleus, and a higher mitotic rate than in the rest of the neoplasm.
2058
Image ID:2058
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma: the neoplasm is composed of papillary projections lined by a one cell-thick cuboidal epithelium that also forms small glands and solid areas. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small to moderate amount of acidophilic cytoplasm. The nucleus tends to be basal, oval, and medium-sized.
2056
Image ID:2056
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma: the neoplasm in this area is composed of glands supported by a scant amount . Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small to moderate amount of acidophilic cytoplasm. The nucleus tends to be basal, oval, and medium-sized. There is, at the center of the photomicrograph, an area where neoplastic cells are larger, have a paler cytoplasm, a larger and paler nucleus, and a higher mitotic rate than in the rest of the neoplasm (early transition into a carcinoma).
2057
Image ID:2057
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplasm that arises within a duct (the duct was cut open during the preparation of the specimen). The lumen of the duct is filled with multiple papillary projections supported by delicate fibrovascular projections. Numerous hyperplastic alveolar nodules are present in the nearby mammary parenchyma.
2054
Image ID:2054
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29377 Mammary gland   carcinoma Mammary gland None (spontaneous)
FVB-Tg(WapTgfa)215Bri
 Female reproductive status not specified observed 210 days Papilloma, intraductal, with early transformation into a carcinoma, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplasm that arises within a duct (the duct was cut open during the preparation of the specimen). The lumen of the duct is filled with multiple papillary projections supported by delicate fibrovascular projections. Numerous hyperplastic alveolar nodules are present in the nearby mammary parenchyma.
2054
Image ID:2054
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma, area of early transformation into a carcinoma: neoplastic cells at the center of the photomicrograph are larger, have a paler cytoplasm, a larger and paler nucleus, and a higher mitotic rate than in the rest of the neoplasm.
2058
Image ID:2058
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma: the neoplasm in this area is composed of glands supported by a scant amount . Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small to moderate amount of acidophilic cytoplasm. The nucleus tends to be basal, oval, and medium-sized. There is, at the center of the photomicrograph, an area where neoplastic cells are larger, have a paler cytoplasm, a larger and paler nucleus, and a higher mitotic rate than in the rest of the neoplasm (early transition into a carcinoma).
2057
Image ID:2057
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, unencapsulated, densely cellular neoplasm that arises within a duct (the duct was cut open during the preparation of the specimen). The lumen of the duct is filled with multiple papillary projections supported by delicate fibrovascular projections. Numerous hyperplastic alveolar nodules are present in the nearby mammary parenchyma.
2055
Image ID:2055
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Papillary adenoma: the neoplasm is composed of papillary projections lined by a one cell-thick cuboidal epithelium that also forms small glands and solid areas. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small to moderate amount of acidophilic cytoplasm. The nucleus tends to be basal, oval, and medium-sized.
2056
Image ID:2056
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29432 Mammary gland   hyperplasia - atypical Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 84 days Atypical hyperplasia, mild, mammary gland J:94320
Image Caption:Mammary gland: the mammary ducts and alveoli are slightly more prominent than normal for a resting mammary gland.
2222
Image ID:2222
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary ducts and alveoli are slightly more prominent than normal for a resting mammary gland.
2223
Image ID:2223
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary ducts and alveoli are slightly more prominent than normal for a resting mammary gland.
2224
Image ID:2224
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary ducts and alveoli are slightly more prominent than normal for a resting mammary gland. The ducts and the acini are lined by a cuboidal epithelium with an abnormally high mitotic activity. Cells with a morphology consistent with that of "large clear cells" (arrowheads) are more numerous than for a normal 84 days old mouse.
2225
Image ID:2225
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29434 Mammary gland   adenocarcinoma Lung None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 168 days Mammary adenocarcinoma, metastatic to the lungs J:94320
Image Caption:Lung: three branches of a large pulomonary artery are filled with large neoplastic emboli. There is moderate necrosis at the center of the neoplastic emboli.
2227
Image ID:2227
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: neoplastic cells have invaded the pulmonary parenchyma. They form anastomosed trabeculae and a few glands supported by a scant amount of fibrovascular stroma. Neoplastic cells at the periphery of neoplastic trabeculae and glands display prominent nuclear palisading, are low columnar, and have an elongated nucleus. Neoplastic cells at the center of neoplastic trabeculae are polygonal with a rounder nucleus than neoplastic cells at the periphery of neoplastic trabeculae.
2232
Image ID:2232
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: three branches of a large pulomonary artery are filled with large neoplastic emboli. There is moderate necrosis at the center of the neoplastic emboli.
2226
Image ID:2226
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: a neoplastic embolus (*) fills the lumen of the distal portions of a pulmonary artery.
2229
Image ID:2229
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: large neoplastic emboli are present in several pulmonary arteries (*). Neoplastic cells have invaded through the wall of the arteries into the pulmonary parenchyma. Invasion of neoplastic cells into the pulmonary parenchyma defines the metastatic stage of cancer progression.
2230
Image ID:2230
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: three branches of a large pulomonary artery are filled with large neoplastic emboli. The pulmonary artery is partly thrombosed (T) and neoplastic cells invade the thrombus. Some portions of the surface of the neoplastic embolus are covered by endothelial cells (arrowhead; re-endothelialization).
2228
Image ID:2228
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: neoplastic cells have invaded the pulmonary parenchyma. They form anastomosed trabeculae and a few glands supported by a scant amount of fibrovascular stroma. Neoplastic cells at the periphery of neoplastic trabeculae and glands display prominent nuclear palisading, are low columnar, and have an elongated nucleus. Neoplastic cells at the center of neoplastic trabeculae are polygonal with a rounder nucleus than neoplastic cells at the periphery of neoplastic trabeculae.
2233
Image ID:2233
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Lung: neoplastic cells have invaded the pulmonary parenchyma. They form anastomosed trabeculae and a few glands supported by a scant amount of fibrovascular stroma. Neoplastic cells at the periphery of neoplastic trabeculae and glands display prominent nuclear palisading, are low columnar, and have an elongated nucleus. Neoplastic cells at the center of neoplastic trabeculae are polygonal with a rounder nucleus than neoplastic cells at the periphery of neoplastic trabeculae.
2231
Image ID:2231
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29435 Mammary gland   adenocarcinoma - solid Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 168 days Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilobular, encapsulated, densely cellular, mostly expansile, locally invasive, neoplasm with a large central area of cavitation (*).
2234
Image ID:2234
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells gradually become spindloid out of a portion of the neoplasm that is solid (on the right of the photomicrograph). Cells that have undergone epithelial to mesenchymal transition are difficult to differentiate from stromal cells.
2244
Image ID:2244
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a portion of the neoplasm that has a trabecular/solid pattern with the presence of numerous secondary lumens. Cords and trabeculae of neoplastic cells invade the capsule.
2236
Image ID:2236
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells gradually become spindloid out of a portion of the neoplasm that is solid (on the right of the photomicrograph). Cells that have undergone epithelial to mesenchymal transition are difficult to differentiate from stromal cells.
2243
Image ID:2243
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a large, multilobular, encapsulated, densely cellular, mostly expansile, locally invasive, neoplasm with a large central area of cavitation. The neoplasm is predominantly composed of solid areas with secondary lumens that can be discerned even at this low magnification. Areas indicative of epithelial to mesenchymal transition and composed of bundles and fascicles are most prominent at the periphery of the area of cavitation.
2235
Image ID:2235
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a portion of the neoplasm that has a trabecular/solid pattern separated by a small to moderate amount of moderately dense fibrovascular stroma. Neoplastic cell are polygonal, medium-size, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, medium-size and hyperchromatic.
2238
Image ID:2238
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where there is gradual transition between a solid pattern (left side of the photomicrograph) to a spindloid pattern (right side of the photomicrograph) characterized by the formation of interlacing fascicles. The stroma in the solid areas is more abundant and more fibrous than at the periphery of the neoplasm. The stroma is more edematous and less fibrous in the portions of the neoplasm composed of spindloid cells. Neoplastic cells still form a few glands with prominent lumens (arrowheads).
2241
Image ID:2241
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where there is gradual transition between a solid pattern (left side of the photomicrograph) to a spindloid pattern (right side of the photomicrograph) characterized by the formation of interlacing fascicles. The stroma is more abundant and more fibrous than at the periphery of the neoplasm.
2240
Image ID:2240
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a portion of the neoplasm that has a trabecular/solid pattern separated by a small to moderate amount of moderately dense fibrovascular stroma. Neoplastic cell are polygonal, medium-size, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a large lipid vacuole. The nucleus is central, oval, medium-size and hyperchromatic. Small clusters of neoplastic cells invade the capsule.
2239
Image ID:2239
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells gradually become spindloid although most of them have retained many features of epithelial cells, including angular cell contours, occasionally organization of neoplastic cells in glands, and an oval nucleus. Some neoplastic cells are fusiform with and elongated nucleus.
2242
Image ID:2242
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid mammary carcinoma: this photomicrograph illustrates a portion of the neoplasm that has a trabecular/solid pattern separated by a small to moderate amount of moderately dense fibrovascular stroma. Secondary lumens are prominent in the upper left portions of the photomicrograph. Neoplastic cell are polygonal, medium-size, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm.
2237
Image ID:2237
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29436 Mammary gland   adenocarcinoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 140 days Adenocarcinoma, solid, comedo, mammary gland J:94320
Image Caption:Solid and comedo mammary carcinoma: neoplastic cells are closely packed, medium-size, polygonal, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-size, with a slightly contoured nuclear membrane, normochromatic, a clumped chromatin and 1-3 small nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. Neoplastic cells in some places seem to be located in the stroma of the neoplasm and are not separated from the stroma by a discrete basement membrane.
2250
Image ID:2250
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: multiple neoplasms are arising in this mammary gland. The largest neoplasm is nodular, expansile, and densely cellular. It is composed of solid areas with central necrosis.
2245
Image ID:2245
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expansile, and densely cellular neoplasm. It is composed of solid areas with central necrosis.
2246
Image ID:2246
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expansile, and densely cellular neoplasm. It is composed of solid areas with central necrosis. Solid areas are separated by a small amount of moderately dense fibrovascular stroma.
2247
Image ID:2247
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is expanded by a nodular, expansile, and densely cellular neoplasm. It is composed of solid areas with central necrosis. Solid areas are separated by a small amount of moderately dense fibrovascular stroma. Neoplastic cells form a few trabeculae and nests at the periphery of the neoplasm.
2248
Image ID:2248
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Solid and comedo mammary carcinoma: neoplastic cells are closely packed, medium-size, polygonal, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-size, with a slightly contoured nuclear membrane, normochromatic, a clumped chromatin and 1-3 small nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated.
2249
Image ID:2249
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29437 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 140 days Ductal carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: the architecture of a mammary lobule is maintained but the ducts of the mammary glands are obliterated by closely-packed neoplastic cells. Neoplastic cells are composed of several populations of cells. Some of these cells are pale, large, polygonal, with a large hypochromatic and round nucleus. Some other cells are columnar with a slightly elongated hyperchromatic nucleus. Many cells have a phenotype that is intermediate between the two types described above. Cells with a myoepithelial phenotype seem to be partly lining these ducts. The adjacent ducts and alveoli are lined by a cuboidal epithelium that has a "crowded" appearance, although there is no evidence of atypia. Mild to moderate interstitial fibrosis and pleocellular inflammation are presnt at the periphery of the ducts packed with neoplastic cells.
2251
Image ID:2251
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of a mammary lobule is maintained but the ducts of the mammary glands are obliterated by closely-packed neoplastic cells. Neoplastic cells are composed of several populations of cells. Some of these cells are pale, large, polygonal, with a large hypochromatic and round nucleus. Some other cells are columnar with a slightly elongated hyperchromatic nucleus. Many cells have a phenotype that is intermediate between the two types described above. Cells with a myoepithelial phenotype seem to be partly lining these ducts. Mild to moderate interstitial fibrosis and pleocellular inflammation are presnt at the periphery of the ducts packed with neoplastic cells.
2252
Image ID:2252
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29438 Mammary gland   hyperplasia - atypical Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 140 days Hyperplasia, atypical, mammary gland J:94320
Image Caption:Mammary gland: the architecture of mammary lobules is preserved. Ducts and acini are mildly distended by a proteinaceous fluid, lipid vacuoles, and desquamated dysplastic cells. They are lined by a cuboidal epithelium where cells generally do not pile-up disordely. There is mild fibrosis and interstitial pleocellular inflammation. The mammary fat pad contains brown fat pad.
2253
Image ID:2253
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of mammary lobules is preserved. Ducts and acini are mildly distended by a proteinaceous fluid, lipid vacuoles, and desquamated dysplastic cells. They are lined by a cuboidal epithelium where cells generally do not pile-up disordely. Some cells (arrowheads) lining these ducts resemble the "large clear cells", a type of cell that is less differentiated than most of the other luminal cells. There is mild fibrosis and interstitial pleocellular inflammation. The mammary fat pad contains brown fat pad (left portions of the photomicrograph).
2254
Image ID:2254
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29439 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 140 days Ductal carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: the architecture of the mammary gland is preserved. The lumen of the ducts and alveoli of a few acini is moderately distended by closely-packed neoplastic cells.
2255
Image ID:2255
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is preserved. The lumen of the ducts and alveoli of a few acini is moderately distended by closely-packed neoplastic cells that form solid areas with a few linear clefts. These cells are medium-size, polygonal, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval to slightly elongated, medium-size, oval to elongated, normochromatic, with a coarsely clumped chromatin and 1-2 inconspicuous basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. There is mild fibrosis and pleocllular inflammation at the periphery of the affected ducts and acini.
2256
Image ID:2256
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is preserved. The lumen of the ducts and alveoli of a few acini is moderately distended by closely-packed neoplastic cells. These cells are medium-size, polygonal, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval, medium-size, oval, normochromatic, with a finely stippled chromatin and 1-2 inconspicuous basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. A few neoplastic cells undergo single cell necrosis. There is mild fibrosis and pleocllular inflammation at the periphery of the affected ducts and acini.
2257
Image ID:2257
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the architecture of the mammary gland is preserved. The lumen of the ducts and alveoli of a few acini is moderately distended by closely-packed neoplastic cells that form solid areas with a few linear clefts. These cells are medium-size, polygonal, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval to slightly elongated, medium-size, oval to elongated, normochromatic, with a coarsely clumped chromatin and 1-2 inconspicuous basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. Myoepithelial differentiation seems to be present at this stage of the disease. There is mild fibrosis and pleocllular inflammation at the periphery of the affected ducts and acini.
2258
Image ID:2258
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29440 Mammary gland   carcinoma - mixed Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 140 days Carcinoma, solid, with spindloid differentiation, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a multilobular, ill-defined, densely cellular neoplasm. This neoplasm is predominantly composed of solid areas that gradually blend into the adjacent fibrovascular stroma. During this process, some neoplastic cells acquired an spindloid phenotype.
2259
Image ID:2259
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a multilobular, ill-defined, densely cellular neoplasm. This neoplasm is predominantly composed of solid areas that gradually blend into the adjacent fibrovascular stroma. During this process, some neoplastic cells acquired an spindloid phenotype. Neoplastic cells are oat-shaped to spindloid, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is oval to elongated, normochromatic to slightly hypochromatic, with a clumped to stippled chromatin, and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. Numerous neoplastic cells undergo single cell necrosis. There is a mild lymphocytic infiltration at the periphery of the neoplasm.
2261
Image ID:2261
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a multilobular, ill-defined, densely cellular neoplasm. This neoplasm is predominantly composed of solid areas that gradually blend into the adjacent fibrovascular stroma. During this process, some neoplastic cells acquired an spindloid phenotype. Neoplastic cells are oat-shaped to spindloid, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is oval to elongated, normochromatic to slightly hypochromatic, with a clumped to stippled chromatin, and 1-3 small basophilic nucleoli. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. Numerous neoplastic cells undergo single cell necrosis. There is a mild lymphocytic infiltration at the periphery of the neoplasm.
2260
Image ID:2260
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29441 Mammary gland   adenocarcinoma Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 98 days Adenocarcinoma, glandular, mammary gland J:94320
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, densely cellular, invasive neoplasm. This neoplasm is composed of closely-packed glands supported by a small to moderate amount of fibrovascular stroma.
2264
Image ID:2264
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, densely cellular, invasive neoplasm. This neoplasm is composed of closely-packed glands supported by a small to moderate amount of fibrovascular stroma.
2263
Image ID:2263
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells had a more abundant and more acidophilic cytoplasm. The pattern of the neoplasm in this area was glandular to solid and nuclear palissading is lost.
2270
Image ID:2270
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed glands supported by a moderate amount of fibrovascular stroma (the stroma was less abundant in some fields). Neoplastic cells are cuboidal, medium-sized, with indistinct cell borders, and a moderate amount of strongly acidophilic cytoplasm. The nucleus is basal, oval to round, and hyperchromatic. Anisokaryosis sand anisocytosis are mild. Inflammation is minimal.
2266
Image ID:2266
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells had a more abundant and more acidophilic cytoplasm. The pattern of the neoplasm in this area was glandular to solid.
2268
Image ID:2268
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of closely-packed glands supported by a small to moderate amount of fibrovascular stroma. Neoplastic cells are cuboidal, medium-sized, with indistinct cell borders, and a moderate amount of strongly acidophilic cytoplasm. The nucleus is basal, oval to round, and hyperchromatic. Anisokaryosis sand anisocytosis are mild. Inflammation is minimal.
2265
Image ID:2265
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells had a more abundant and more acidophilic cytoplasm. The pattern of the neoplasm in this area was glandular to solid and nuclear palissading is lost.
2271
Image ID:2271
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates an area of invasion of the panniculus at the periphery of the neoplasm.
2267
Image ID:2267
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Glandular mammary adenocarcinoma: this photomicrograph illustrates a portion of the neoplasm where neoplastic cells had a more abundant and more acidophilic cytoplasm. The pattern of the neoplasm in this area was glandular to solid and nuclear palissading is lost.
2269
Image ID:2269
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, well-delineated, densely cellular, invasive neoplasm. This neoplasm is composed of closely-packed glands supported by a small to moderate amount of fibrovascular stroma.
2262
Image ID:2262
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29442 Mammary gland   hyperplasia - atypical - ductal Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 98 days Atypical ductal hyperplasia, mammary gland J:94320
Image Caption:Mammary gland: an intralobular duct and most acini or a mammary lobule are lined by a prominent epithelium. Cells forming this epithelium are cuboidal to polygonal, with a moderate amount of pale basophilic cytoplasm and a medium-size hypochromatic nucleus.
2272
Image ID:2272
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: an intralobular duct and most acini or a mammary lobule are lined by a prominent epithelium. Cells forming this epithelium are cuboidal to polygonal, with a moderate amount of pale basophilic cytoplasm and a medium-size hypochromatic nucleus. Some of these clear cells are surrounded by 2 cells with a small elongated hyperchromatic nucleus oriented at right angle with the basement membrane (arrowheads). Myoepithelial differentiation can still be recognized (arrow).
2273
Image ID:2273
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29443 Mammary gland   carcinoma in situ - ductal Mammary gland None (spontaneous)
FVB/N-Tg(C3-1-TAg)cJeg
 Female reproductive status not specified observed 98 days Ductal carcinoma in situ, mammary gland J:94320
Image Caption:Mammary gland: a mammary lobule is more prominent than nearby lobules. The intralobular ducts and the acini of this lobule are mildly distended by epithelial cells. The center of some solid areas is often necrotic. Cells at the periphery of the lobules are smaller, often slightly attenuated, with a nucleus oriented parallel to the basement membrane, and with a small amount of strongly amphophilic cytoplasm. These features are consistent with myoepithelial differentiation. Cells at the center of the lobules are larger, polygonal, with a moderate amount of pale basophilic cytoplasm and a medium-size hypochromatic nucleus. Mitotic figures are numerous.
2275
Image ID:2275
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is more prominent than nearby lobules. The intralobular ducts and the acini of this lobule are mildly distended by epithelial cells. The center of some solid areas is often necrotic. Cells at the periphery of the lobules are smaller, often slightly attenuated, with a nucleus oriented parallel to the basement membrane, and with a small amount of strongly amphophilic cytoplasm. These features are consistent with myoepithelial differentiation. Cells at the center of the lobules are larger, polygonal, with a moderate amount of pale basophilic cytoplasm and a medium-size hypochromatic nucleus. Mitotic figures are numerous.There is mild interstitial fibrosis.
2276
Image ID:2276
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: a mammary lobule is more prominent than nearby lobules. The intralobular ducts and the acini of this lobule are mildly distended by epithelial cells.
2274
Image ID:2274
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29462 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LauraGfc
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma. The lumen of some glands contains clumps of degenerated neoplastic cells. Neoplastic cells are cuboidal and have a moderate amount of acidophilic cytoplasm. The nucleus is medium-sized, central and oval. Fixation artifacts prevent further interpretation of these tissues.
2409
Image ID:2409
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma.
2407
Image ID:2407
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with slender papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma. The lumen of some glands contains clumps of degenerated neoplastic cells. Neoplastic cells are cuboidal and have a moderate amount of acidophilic cytoplasm. The nucleus is medium-sized, central and oval. Fixation artifacts prevent further interpretation of these tissues.
2410
Image ID:2410
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma.
2406
Image ID:2406
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary gland is effaced by a multilobular, densely cellular, unencapsulated neoplastic mass.
2405
Image ID:2405
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma. The lumen of some glands contains clumps of degenerated neoplastic cells. Neoplastic cells are cuboidal and have a moderate amount of acidophilic cytoplasm. The nucleus is medium-sized, central and oval. Fixation artifacts prevent further interpretation of these tissues.
2408
Image ID:2408
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of ectatic glands which are partially filled with slender papillary projections. These epithelial structures are lined by a one cell-thick cuboidal epithelium supported by a small amount of dense fibrovascular stroma. The lumen of some glands contains clumps of degenerated neoplastic cells. Neoplastic cells are cuboidal and have a moderate amount of acidophilic cytoplasm. The nucleus is medium-sized, central and oval. Fixation artifacts prevent further interpretation of these tissues.
2411
Image ID:2411
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29463 Mammary gland   hyperplasia - atypical Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LauraGfc
 Female reproductive status not specified observed unknown Atypical hyperplasia and interstitial fibrosis, mammary gland J:94320
Image Caption:Dysplasia, hyperplasia and interstitial fibrosis of the mammary gland: most intralobular ducts and most acini are filled by an amorphous acidophilic material. There is moderate to locally marked periacinar and periductular fibrosis. Cells lining mammary acini and ducts do not pile-up but they have more cytoplasm and a larger nucleus than normally. Immunohistochemistry for myoepithelial markers would be needed to determine whether myoepithelial differentiation is maintained in these lesions.
2414
Image ID:2414
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobular architecture of the mammary gland is prominent. Most intralobular ducts and most acini are filled by an amorphous acidophilic material. There is moderate to locally marked periacinar and periductular fibrosis. Cells lining mammary acini and ducts do not pile-up. Immunohistochemistry for myoepithelial markers would be needed to determine whether myoepithelial differentiation is maintained in these lesions.
2412
Image ID:2412
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the lobular architecture of the mammary gland is prominent. Most intralobular ducts and most acini are filled by an amorphous acidophilic material. There is moderate to locally marked periacinar and periductular fibrosis. Cells lining mammary acini and ducts do not pile-up. Immunohistochemistry for myoepithelial markers would be needed to determine whether myoepithelial differentiation is maintained in these lesions.
2413
Image ID:2413
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29465 Mammary gland   carcinoma - papillary Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LauraGfc
 Female reproductive status not specified observed unknown Intraductal papillary carcinoma, mammary gland J:94320
Image Caption:Mammary gland: the epithelium of several interlobular ducts forms small papillae. The lumen of these papillae contains necrotic epithelial cells. There is moderate periductal fibrosis. Adjacent mamamry acini are moderately ectatic, contain necrotic epithelial cells, and are surrounded by moderate fibrosis with mild to moderate pleocellular inflammation.
2415
Image ID:2415
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29471 Mammary gland   adenoacanthoma Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LauraGfc
 Female reproductive status not specified observed unknown Adenocarcinoma, glandular, with squamous metaplasia (adenoacanthoma), mammary gland J:94320
Image Caption:Mammary gland: this is a nodular, well-delineated, unencapsulated, densely cellular neoplasm. Cytological details are poor because the tissue was fixed in ethanol.
2416
Image ID:2416
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a nodular, well-delineated, unencapsulated, densely cellular neoplasm. The neoplasm is composed of interconnected ducts separated by a moderate amount of dense fibrovascular stroma. Cytological details are poor because the tissue was fixed in ethanol.
2417
Image ID:2417
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a nodular, well-delineated, unencapsulated, invasive, densely cellular neoplasm. The neoplasm is composed of interconnected ducts separated by a moderate amount of dense fibrovascular stroma. There are numerous areas of cornification which appear as concentric whirls of a strongly acidophilic material. There is a mild to moderate lymphocytic and plasmacytic infiltrate at the periphery of the tumor. Cytological details are poor because the tissue was fixed in ethanol.
2419
Image ID:2419
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there are numerous areas of cornification which appear as concentric whirls of a strongly acidophilic material. The cytoplasm of a few cells in these areas of cornification contain keratohyalin granules (arrowhead). There is a mild to moderate lymphocytic and plasmacytic infiltrate (L) at the periphery of the tumor. Cytological details are poor because the tissue was fixed in ethanol.
2421
Image ID:2421
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a nodular, well-delineated, unencapsulated, invasive, densely cellular neoplasm. The neoplasm is composed of interconnected ducts separated by a moderate amount of dense fibrovascular stroma. There are numerous areas of cornification which appear as concentric whirls of a strongly acidophilic material. There is a mild to moderate lymphocytic and plasmacytic infiltrate at the periphery of the tumor. Cytological details are poor because the tissue was fixed in ethanol.
2420
Image ID:2420
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: this is a nodular, well-delineated, unencapsulated, invasive, densely cellular neoplasm. The neoplasm is composed of interconnected ducts separated by a moderate amount of dense fibrovascular stroma. There are numerous areas of cornification which appear as concentric whirls of a strongly acidophilic material. There is a mild to moderate lymphocytic and plasmacytic infiltrate at the periphery of the tumor. Cytological details are poor because the tissue was fixed in ethanol.
2418
Image ID:2418
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29472 Mammary gland   adenocarcinoma - papillary Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LesleyGfc
 Female reproductive status not specified observed unknown Adenocarcinoma, papillary, mammary gland J:94320
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium and supported by a moderate amount of fibrovascular stroma with a moderate pleocellular inflammation. The epithelium of numerous ducts forms small papillae supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal. Cytological details are poor because the tissue was fixed in ethanol.
2425
Image ID:2425
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: there is a nodular, unencapsulated, densely cellular, invasive neoplasm in the right portion of the specimen. The left portion of the specimen contains multiple small areas of intraductal carcinoma. Cytological details are poor because the tissue was fixed in ethanol.
2422
Image ID:2422
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is effaced by a nodular, unencapsulated, densely cellular, invasive neoplasm. This neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium and supported by a moderate amount of fibrovascular stroma with a moderate pleocellular inflammation. The epithelium of numerous ducts forms small papillae supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal. Cytological details are poor because the tissue was fixed in ethanol.
2424
Image ID:2424
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the mammary parenchyma is effaced by a nodular, unencapsulated, densely cellular, invasive neoplasm. This neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium and supported by a moderate amount of fibrovascular stroma with a moderate pleocellular inflammation. Cytological details are poor because the tissue was fixed in ethanol.
2423
Image ID:2423
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: the neoplasm is composed of interconnected ducts lined by a one cell-thick epithelium and supported by a moderate amount of fibrovascular stroma with a moderate pleocellular inflammation. The epithelium of numerous ducts forms small papillae supported by a scant amount of fibrovascular stroma. Neoplastic cells are cuboidal. Cytological details are poor because the tissue was fixed in ethanol.
2426
Image ID:2426
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:29473 Mammary gland   carcinoma - papillary Mammary gland None (spontaneous)
B6;CB-Tg(PAEP-Igf2)LesleyGfc
 Female reproductive status not specified observed unknown Intraductal papillary carcinoma, mammary gland J:94320
Image Caption:Mammary gland: all mammary ducts and alveoli are moderately ectatic and are lined by a one cell-thick epithelium that forms numerous small papillary projections. There is moderate interstitial fibrosis and pleocellular inflammation at the periphery of these ducts and alveoli. Many ducts and alveoli contain a moderate number of desquamated and degenerated neoplastic epithelial cells. Cytological details are poor because the tissue was fixed in ethanol.
2429
Image ID:2429
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: all mammary ducts and alveoli are moderately ectatic and are lined by a one cell-thick epithelium that forms numerous small papillary projections. There is moderate interstitial fibrosis and pleocellular inflammation at the periphery of these ducts and alveoli. Cytological details are poor because the tissue was fixed in ethanol.
2427
Image ID:2427
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: all mammary ducts and alveoli are moderately ectatic and are lined by a one cell-thick epithelium that forms numerous small papillary projections. There is moderate interstitial fibrosis and pleocellular inflammation at the periphery of these ducts and alveoli. Many ducts and alveoli contain a moderate number of desquamated and degenerated neoplastic epithelial cells. Cytological details are poor because the tissue was fixed in ethanol.
2430
Image ID:2430
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
Image Caption:Mammary gland: all mammary ducts and alveoli are moderately ectatic and are lined by a one cell-thick epithelium that forms numerous small papillary projections. There is moderate interstitial fibrosis and pleocellular inflammation at the periphery of these ducts and alveoli. Many ducts and alveoli contain a moderate number of desquamated and degenerated neoplastic epithelial cells. Cytological details are poor because the tissue was fixed in ethanol.
2428
Image ID:2428
Source of Image:Ward JM
Pathologist:Mikaelian I
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:69591 Spleen   hyperplasia - splenic marginal zone Spleen None (spontaneous)
B6;129-Trp53tm1Brd
 Unspecified reproductive status not specified observed splenic marginal zone hyperplasia J:107304
Image Caption:This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/15602/.
5752
Image ID:5752
Source of Image:Ward JM
Pathologist:Ward JM
Method / Stain:H&E
MTB ID Tumor Name Organ(s) Affected Treatment Type Agents Strain Name Strain Sex Reproductive Status Tumor Frequency Age at Necropsy Description Reference
MTB:100592 (Unspecified organ)   normal tissue (control) (Unspecified organ) None (spontaneous)
[not specified]
 Unspecified reproductive status not specified not applicable Normal Control J:107304
Image Caption:This is the normal control slide for CD45R staining. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/16004/.
6517
Image ID:6517
Source of Image:Ward JM
Pathologist:Ward JM
Image Caption:This is the normal control slide for CD3 staining. A whole-slide scan image cane be viewed at https://images.jax.org/webclient/img_detail/16001/.
6516
Image ID:6516
Source of Image:Ward JM
Pathologist:Ward JM