|
| MTB ID |
Tumor Name |
Organ(s) Affected |
Treatment Type |
Agents |
Strain Name |
Strain Sex |
Reproductive Status |
Tumor Frequency |
Age at Necropsy |
Description |
Reference |
| MTB:27655 |
Intestine - Small Intestine normal tissue (control) |
Intestine - Small Intestine |
None (spontaneous) |
|
|
Unspecified |
reproductive status not specified |
not applicable |
35 days |
Small intestine - normal tissue. Bromodeoxyuridine immunohistochemistry |
J:94320 |
|
Image Caption:Small intestine - normal tissue. There is strong nuclear labeling for bromodeoxyuridine (BrdU) of epithelial cells of the crypts (antibody diluted at 1:20, tissue fixed in Fekete's solution, with antigen retrieval: 0.05% trypsin 1-2 min; rince; DNA denaturation with HCl 2N, 15 min; Sodium Borate 0.1M pH=8.5, 1 min).
|
|
|
Image ID:1331 |
|
Source of Image:Mikaelian I |
|
Pathologist:Mikaelian I |
|
Method / Stain:IHC for bromodeoxyuridine |
|
|
Image Caption:Small intestine - normal tissue. There is strong nuclear labeling for bromodeoxyuridine (BrdU) of epithelial cells of the crypts (antibody diluted at 1:20, tissue fixed in Fekete's solution, with antigen retrieval: 0.05% trypsin 1-2 min; rince; DNA denaturation with HCl 2N, 15 min; Sodium Borate 0.1M pH=8.5, 1 min).
|
|
|
Image ID:1330 |
|
Source of Image:Mikaelian I |
|
Pathologist:Mikaelian I |
|
Method / Stain:IHC for bromodeoxyuridine |
|
|
|
| MTB ID |
Tumor Name |
Organ(s) Affected |
Treatment Type |
Agents |
Strain Name |
Strain Sex |
Reproductive Status |
Tumor Frequency |
Age at Necropsy |
Description |
Reference |
| MTB:22217 |
Pituitary gland - Pars intermedia tumor |
Pituitary gland - Pars intermedia |
None (spontaneous) |
|
|
Unspecified |
reproductive status not specified |
very high |
6.5 month |
"Midsagittal section of pituitary tumors stained with BrdUrd showing 2.3 +/- 0.6% positive nuclei. Only low level of apoptosis observed by both TUNEL staining and study of H&E stained slides for hallmarks of apoptosis such as marginated chromatin and fragmented nuclei." |
J:81016 |
|
Image Caption: These animals were injected with BrdUrd (10 mg/kg body weight) 1 h before death, and analysis of BrdUrd incorporation demonstrated a significantly higher S-phase fraction (P < 0.05 for three matched pairs) in the Rb+/-; ARF-/- sample (D) relative to the Rb+/- control (C).
|
|
|
Image ID:2969 |
|
Source of Image:Tsai KY |
|
Pathologist:Tsai KY |
|
Method / Stain:H&E |
|
|
|
| MTB ID |
Tumor Name |
Organ(s) Affected |
Treatment Type |
Agents |
Strain Name |
Strain Sex |
Reproductive Status |
Tumor Frequency |
Age at Necropsy |
Description |
Reference |
| MTB:22219 |
Pituitary gland - Pars intermedia tumor |
Pituitary gland - Pars intermedia |
None (spontaneous) |
|
|
Unspecified |
reproductive status not specified |
very high |
4.5 months |
Midsagittal section of a pituitary tumor stained with BrdUrd showing 15.3 +/- 4% positive nuclei. Only low levels of apoptosis were observed by either TUNEL staining or study of H&E stained slides. Tumor size and stage was similar to that found in 6.5 month old Rb1 heterozygote mouse. |
J:81016 |
|
Image Caption:These animals were injected with BrdUrd (10 mg/kg body weight) 1 h before death, and analysis of BrdUrd incorporation demonstrated a significantly higher S-phase fraction (P < 0.05 for three matched pairs) in the Rb+/=; ARF-/- sample (D) relative to the Rb+/= control (C).
|
|
|
Image ID:2970 |
|
Source of Image:Tsai KY |
|
Pathologist:Tsai KY |
|
Method / Stain:BRDU |
|
|
|
| MTB ID |
Tumor Name |
Organ(s) Affected |
Treatment Type |
Agents |
Strain Name |
Strain Sex |
Reproductive Status |
Tumor Frequency |
Age at Necropsy |
Description |
Reference |
| MTB:27693 |
Skin normal tissue (control) |
Skin |
None (spontaneous) |
|
|
Unspecified |
reproductive status not specified |
not applicable |
35 days |
Haired skin - Normal tissue. Bromodeoxyuridine immunohistochemistry |
J:94320 |
|
Image Caption:Haired skin - Normal tissue. There is strong nuclear labeling for bromodeoxyuridine (BrdU) of epithelial cells of the bulb of the hair follicle (antibody diluted at 1:20, tissue fixed in Fekete's solution, with antigen retrieval: 0.05% trypsin 1-2 min; rince; DNA denaturation with HCl 2N, 15 min; Sodium Borate 0.1M pH=8.5, 1 min).
|
|
|
Image ID:1328 |
|
Source of Image:Mikaelian I |
|
Pathologist:Mikaelian I |
|
Method / Stain:IHC for bromodeoxyuridine |
|
|