Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets
Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology
Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice
Send Questions and
Comments to User Support.
Last Database Update
2020-05-31
MTB 3.0
 
HelpHelp and Documentation Pathology Image Search Results  
Search Summary
Organ/Tissue of Origin: Adrenal gland
Sort By: Organ
Display Limit: 5
5 (of 24) pathology reports displayed, including 16 images.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents		 Strain Name
Strain Sex
Reproductive Status		 Tumor
Frequency		 Age at
Necropsy		 Description Reference
MTB:50789 Adrenal gland   hyperplasia - spindle cell Adrenal gland None (spontaneous) BALB/cByJ
Female
reproductive status not specified		 observed 877 days adrenal cortical spindle cell sarcoma and hyperplasia J:122261
5022
Image ID:
 5022
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 25x image that is a higher magnification of the right-center area of the 10x image.
5023
Image ID:
 5023
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 40x image, 40xa, that is a higher magnification of the left-center area of the 4x image.
5020
Image ID:
 5020
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 4x image.
5025
Image ID:
 5025
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 40x image, 40xc, that is a higher magnification of the center area of the 25x image.
5021
Image ID:
 5021
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 10x image that is a higher magnification of the lower-center area of the 4x image.
5024
Image ID:
 5024
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 40x image, 40xb, that is a higher magnification of the lower-left area of the 10x image.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents		 Strain Name
Strain Sex
Reproductive Status		 Tumor
Frequency		 Age at
Necropsy		 Description Reference
MTB:64312 Adrenal gland   hyperplasia - spindle cell Adrenal gland None (spontaneous) C3B6F2
Female
reproductive status not specified		 observed 562 days adrenal gland spindle cell hyperplasia J:122261
5561
Image ID:
 5561
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 2.5x image.
5563
Image ID:
 5563
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 40x image, 40x, that is a higher magnification of the right, middle region of the 4x image.
5562
Image ID:
 5562
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Image Caption:
This is a 4x image, 4x, that is a higher magnification of the right, middle area of the 2.5x image.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents		 Strain Name
Strain Sex
Reproductive Status		 Tumor
Frequency		 Age at
Necropsy		 Description Reference
MTB:11341 Adrenal gland - Cortex   adenoma Adrenal gland - Cortex None (spontaneous) C3H/HeJ
Male
reproductive status not specified		 observed J:94307
122
Image ID:
 122
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Method / Stain:
 chromium fixation method for adrenal medulla
Image Caption:
Adrenocortical adenoma. Chromium fixation delineates the adrenal medulla (brown staining). The blue nodule in the cortex compresses the adjacent normal cells. The tumor cells form small islands of polyhedral cells in a typical "endocrine" pattern.
121
Image ID:
 121
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Method / Stain:
 chromium fixation method for adrenal medulla
Image Caption:
Adrenocortical adenoma. The classical histochemical approach to evaluating the adrenal medulla is to fix it in chromium based fixatives as shown here. The medulla stains brown while the remainder of the gland, the cortex, is blue due to the counterstain. In the upper right quadrant of the cortex is a dark blue nodule that is an adrenal cortical adenoma since it does not stain brown, is located within the adrenal cortex, and has cellular features consistent with the cortical cells.
120
Image ID:
 120
Source of Image:
 Sundberg J
Pathologist:
 Sundberg J
Method / Stain:
 IHC for tyrosine hydroxylase
Image Caption:
Adrenocortical adenoma. The kidney is in the upper left corner of this image. The adrenal gland has been subjected to immunohistochemistry for detection of expression of tyrosine hydroxylase. The center of the gland (adrenal medulla) is positive for this enzyme (dark brown). The cortex is blue due to the counterstain (hematoxylin). To the right of the medulla is an round mass that compresses the cortex. The cells resemble the cortex and do not express tyrosine hydroxylase and therefore are most likely of adrenal cortex origin.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents		 Strain Name
Strain Sex
Reproductive Status		 Tumor
Frequency		 Age at
Necropsy		 Description Reference
MTB:18163 Adrenal gland - Cortex   carcinoma Adrenal gland - Cortex None (spontaneous) [not specified]-Men1tm1Ctre/+
Mixed Population
reproductive status not specified		 15% 15 months adrenal cortical tumor J:67128
3109
Image ID:
 3109
Source of Image:
 Crabtree JS
Pathologist:
 Crabtree JS
Method / Stain:
 H&E
Image Caption:
(c) H&E-stained section (?40) of adrenal cortical tumor from a 15-month-old mouse.


MTB ID Tumor Name Organ(s) Affected Treatment Type
Agents		 Strain Name
Strain Sex
Reproductive Status		 Tumor
Frequency		 Age at
Necropsy		 Description Reference
MTB:18397 Adrenal gland - Cortex   carcinoma Adrenal gland - Cortex None (spontaneous) C.129S2(B6)-Trp53tm1Tyj/J
Female
reproductive status not specified		 observed 389 days Type A spindle cell adrenocortical carcinoma J:94310
364
Image ID:
 364
Source of Image:
 Mikaelian I
Pathologist:
 Mikaelian I
Method / Stain:
 H&E
Image Caption:
Type A spindle cell adrenocortical carcinoma. The neoplasm is located on the left and has caused edema and necrosis of many adrenal cortical cells on the right. This is evidenced by the many clear spaces between the cells (edema fluid lost in the tissue processing).
365
Image ID:
 365
Source of Image:
 Mikaelian I
Pathologist:
 Mikaelian I
Method / Stain:
 H&E
Image Caption:
Type A spindle cell adrenocortical carcinoma. The details of the cell type can be seen here. Some cells are spindle shaped with elongated oval nuclei. Cytoplasmic boundries are difficult to identify. Mitotic figures (circles) are frequent. Some pink cortical cells remain but most are lost due to expansion and compression of the primary neoplasm.
363
Image ID:
 363
Source of Image:
 Mikaelian I
Pathologist:
 Mikaelian I
Method / Stain:
 H&E
Image Caption:
Type A spindle cell adrenocortical carcinoma. The cortex of the adrenal gland was effaced by spindle shaped cells (blue cells) that compressed and separated the normal cortical cells (pink)