PDX Model DetailsJ000077960

Request more information on this PDX model.

Model Details

Model ID (Previous ID)
J000077960 ()
Primary Site
Pancreas
Tumor Site
Pancreas
Tumor Type
Primary Malignancy
Initial Diagnosis
pancreas adenocarcinoma
Final Diagnosis
pancreatic ductal adenocarcinoma
Stage/Grade
AJCC IV / Grade:2
Related Models
PDX models J000077960 and J000077973 originated from the same patient.

Patient

Sex
Female
Age
68
Race/Ethnicity
White / Not Reported
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site
Right Flank
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:J000093248     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

No gene CNV data currently available.

CNV Plots

No gene CNV plots currently available.

Model Characterization

Histology: Summary:
P0, P1 pathology consistent with pancreatic adenocarcinoma. 4x and 20x PT images were diagnosed as colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000077960 stained for H&E.

Patient tumor for PDX model J000077960 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000077960 stained for H&E. This is a 20x image.

P0 tumor for PDX model J000077960 stained for H&E.

P0 tumor for PDX model J000077960 stained for CD45. Staining was negative.

P0 tumor for PDX model J000077960 stained for AE1/AE3. Staining was positive.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for H&E.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for CD45. Staining was negative.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for AE1/AE3. Staining was positive.

Dosing Studies