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Last Database Update
2020-02-16
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:J000077960 Previous ID:
Primary Site:Pancreas Initial Diagnosis:pancreas adenocarcinoma Final Diagnosis:pancreatic ductal adenocarcinoma
Tumor Site:Pancreas Tumor Type:Primary Malignancy Stage / Grade:AJCC IV / Grade:2
Related Models: PDX models J000077960 and J000077973 originated from the same patient.
Patient
Sex:Female Age:68 Race / Ethnicity:White / Not Reported
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site:Right Flank Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 4.85
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:J000093248     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
No gene CNV data currently available.
CNV Plots Help
No gene CNV plots currently available.
Model Characterization
Histology: Summary:
Pancreatic Adenocarcinoma. P0 excellent fidelity to PT, CD45 negative AE1/AE3 positive. P1 excellent fidelity to PT, CD45 negative AE1/AE3 positive. 4x and 20x PT images were diagnosed as colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000077960 stained for H&E.

Patient tumor for PDX model J000077960 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000077960 stained for H&E. This is a 20x image.

P0 tumor for PDX model J000077960 stained for H&E.

P0 tumor for PDX model J000077960 stained for CD45. Staining was negative.

P0 tumor for PDX model J000077960 stained for AE1/AE3. Staining was positive.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for H&E.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for CD45. Staining was negative.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for AE1/AE3. Staining was positive.