PDX Model DetailsJ000077960

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PDX Model Summary

Model Details

Model ID
J000077960
Initial Diagnosis
pancreas adenocarcinoma
Final Diagnosis
pancreatic ductal adenocarcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Primary Malignancy

Related Models

PDX models J000077960 and J000077973 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no data

CNV Plots

no data

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:J000093248     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with pancreatic adenocarcinoma. 4x and 20x PT images were diagnosed as colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000077960 stained for H&E.

Patient tumor for PDX model J000077960 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000077960 stained for H&E. This is a 20x image.

P0 tumor for PDX model J000077960 stained for H&E.

P0 tumor for PDX model J000077960 stained for CD45. Staining was negative.

P0 tumor for PDX model J000077960 stained for AE1/AE3. Staining was positive.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for H&E.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for CD45. Staining was negative.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for AE1/AE3. Staining was positive.

Dosing Studies

no data

Circos Plots

no data