PDX Model DetailsJ000079378

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PDX Model Summary

Model Details

Model ID
J000079378
Initial Diagnosis
invasive lobular carcinoma
Final Diagnosis
invasive lobular carcinoma
Stage/Grade
AJCC 1 / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
77
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

no data

Gene CNV

no data

CNV Plots

no data

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 16.15
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

no data

Gene Fusion

no data

Model Characterization

Histology

Tumor Markers:
IHC results show PDX model J000079378 is ER negative/PR negative/ERBB2 negative. Patient tumor reported as ER positive/PR positive/ERBB2 negative.
Summary:
Tumor pathology of the PDX model is consistent with metaplastic breast carcinoma. Passage 3 (P3) tumor is ER and PR negative. Patient and PDX tumor markers differ. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000079378 (aka,BR-1147) stained for H&E.

P0 tumor F006 for model J000079378 strained for H&E.

P0 tumor F006 for model J000079378 strained for Vimentin. Staining was positive.

P1 tumor F002 for model J000079378 strained for H&E.

P1 tumor F002 for model J000079378 strained for AE1AE3. Staining was positive.

P2 tumor F002 ID013 for model J000079378 strained for H&E.

P2 tumor F002 ID013 for model J000079378 strained for AR. Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for ER. Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for ERBB2 (HER2). Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for PR. Staining was negative.

P3 tumor F002 ID20 for model J000079378 strained for PR. Staining was negative.

P3 tumor F002 ID20 for model J000079378 strained for ER. Staining was negative.

Dosing Studies

no data

Circos Plots

no data