PDX Model DetailsJ000079378

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Model Details

Model ID (Previous ID)
J000079378 ()
Primary Site
Breast
Tumor Site
Breast
Tumor Type
Primary Malignancy
Initial Diagnosis
invasive lobular carcinoma
Final Diagnosis
invasive lobular carcinoma
Stage/Grade
AJCC 1 / Grade:3

Patient

Sex
Female
Age
77
Race/Ethnicity
White / Not Reported
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site
Right Flank
Sample Type
Surgical resection (fragment)

Variant Summary

Gene Expression

No gene expression data currently available.

Gene CNV

No gene CNV data currently available.

CNV Plots

No gene CNV plots currently available.

Model Characterization

Histology: Tumor Markers:
IHC results show PDX model J000079378 is ER negative/PR negative/ERBB2 negative. Patient tumor reported as ER positive/PR positive/ERBB2 negative.
Summary:
Tumor pathology of the PDX model is consistent with metaplastic breast carcinoma. Passage 3 (P3) tumor is ER and PR negative. Patient and PDX tumor markers differ. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000079378 (aka,BR-1147) stained for H&E.

P0 tumor F006 for model J000079378 strained for H&E.

P0 tumor F006 for model J000079378 strained for Vimentin. Staining was positive.

P1 tumor F002 for model J000079378 strained for H&E.

P1 tumor F002 for model J000079378 strained for AE1AE3. Staining was positive.

P2 tumor F002 ID013 for model J000079378 strained for H&E.

P2 tumor F002 ID013 for model J000079378 strained for AR. Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for ER. Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for ERBB2 (HER2). Staining was negative.

P2 tumor F002 ID013 for model J000079378 strained for PR. Staining was negative.

P3 tumor F002 ID20 for model J000079378 strained for PR. Staining was negative.

P3 tumor F002 ID20 for model J000079378 strained for ER. Staining was negative.

Dosing Studies