PDX Model DetailsJ000079378

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PDX Model Summary
Model Details	Model ID J000079378 Initial Diagnosis Invasive lobular carcinoma Final Diagnosis Invasive lobular carcinoma Stage/Grade AJCC 1 / Grade:3 Primary Site Breast Sample Site Breast Tumor Type Primary Malignancy
Patient	Sex Female Age (at time of tissue collection) 77 Race/Ethnicity White / Not Reported Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	no expression plots
Gene CNV	no CNV data
CNV Plots	no CNV plots
Tumor Mutation Burden	Sample J000098243 from passage P1 has a TMB score of 16.15 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:J000098243 from passage P1 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Tumor Markers:
IHC results show PDX model J000079378 is ER negative/PR negative/ERBB2 negative. Patient tumor reported as ER positive/PR positive/ERBB2 negative.
Summary:
Tumor pathology of the PDX model is consistent with metaplastic breast carcinoma. Passage 3 (P3) tumor is ER and PR negative. Patient and PDX tumor markers differ. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000079378 (aka,BR-1147) stained for H&E.	P0 tumor F006 for model J000079378 strained for H&E.
P0 tumor F006 for model J000079378 strained for Vimentin. Staining was positive.	P1 tumor F002 for model J000079378 strained for H&E.
P1 tumor F002 for model J000079378 strained for AE1AE3. Staining was positive.	P2 tumor F002 ID013 for model J000079378 strained for H&E.
P2 tumor F002 ID013 for model J000079378 strained for AR. Staining was negative.	P2 tumor F002 ID013 for model J000079378 strained for ER. Staining was negative.
P2 tumor F002 ID013 for model J000079378 strained for ERBB2 (HER2). Staining was negative.	P2 tumor F002 ID013 for model J000079378 strained for PR. Staining was negative.
P3 tumor F002 ID20 for model J000079378 strained for PR. Staining was negative.	P3 tumor F002 ID20 for model J000079378 strained for ER. Staining was negative.