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Last Database Update
MTB 3.0
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00020 Previous ID:BL0382F
Primary Site:Bladder Initial Diagnosis:Carcinoma: Urothelial carcinoma Final Diagnosis:bladder transitional cell carcinoma
Tumor Site:Bladder Tumor Type:Primary Malignancy Stage / Grade:AJCC III / Grade:high
Sex:Female Age:82 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Publications citing this model
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hg10st
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
High concordance of patient tumor morphology with P0 PDX tumor.
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00020. Nests of high grade urothelial carcinoma invading bladder muscle wall.

P0 tumor #1233 for PDX model TM00020. Sheets of high grade urothelial carcinoma cells.

P0 tumor #1235 for PDX model TM00020. Negative staining of tumor cells for vimentin. Scattered positive cells (lymphocytes).

P0 tumor #1235 for PDX model TM00020. Positive staining for Ki67 indicating tumor cells of human origin.
Circos Plots:

Circos plot for P0 tumor #1232 for TM00020

Circos plot for P1 tumor # 0001 from PDX model TM00020
Dosing Studies: