PDX Model DetailsTM00025

This PDX model is not available. (No inventory)

PDX Model Summary

Model Details
Model ID (Previous ID)
TM00025 (BL0470F)
Initial Diagnosis
Carcinoma: Urothelial carcinoma
Final Diagnosis
Bladder urothelial papillary carcinoma
Stage/Grade
AJCC 0 - in situ / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal

Patient
Sex
Female
Age (at time of tissue collection)
55
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BL0470F1820P0 from passage P0 has a TMB score of 4.85
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BL0470F1820P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2, P3 pathology consistent with high grade urothelial carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model TM00025.
P0 tumor for PDX model TM00025.

P2 tumor F1820 ID002 for PDX model TM00025 stained for H&E.
P2 tumor F1820 ID002 for PDX model TM00025 stained for AE1/AE3. Staining was positive.

P2 tumor F1820 ID002 for PDX model TM00025 stained for CD45. Staining was negative.
P2 tumor F1820 ID002 for PDX model TM00025 stained for Ki67. Staining was positive.

P3 tumor F1820 ID020 for PDX model TM0025 stained for H&E.
P3 tumor F1820 ID020 for PDX model TM0025 stained for AE1/AE3. Staining was positive.

P3 tumor F1820 ID020 for PDX model TM0025 stained for CD45. Staining was negative.
P3 tumor F172 ID017 for PDX model TM00927 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

Circos plot