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Last Database Update
2020-03-29
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00025 Previous ID:BL0470F
Primary Site:Bladder Initial Diagnosis:Carcinoma: Urothelial carcinoma Final Diagnosis:bladder urothelial papillary carcinoma
Tumor Site:Bladder Tumor Type:Primary Malignancy Stage / Grade:AJCC 0 - in situ / Grade:high
Patient
Sex:Female Age:55 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Publications citing this model
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 5.66
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:BL0470F1820P0     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:hu133
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P2 pathology consistent with high grade urothelial carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model TM00025.

P0 tumor for PDX model TM00025.

P2 tumor F1820 ID002 for PDX model TM00025 stained for H&E.

P2 tumor F1820 ID002 for PDX model TM00025 stained for AE1/AE3. Staining was positive.

P2 tumor F1820 ID002 for PDX model TM00025 stained for CD45. Staining was negative.

P2 tumor F1820 ID002 for PDX model TM00025 stained for Ki67. Staining was positive.
Circos Plots:

Circos plot
Dosing Studies: