PDX Model DetailsTM00026

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00026 (BL0479F)
Initial Diagnosis
Carcinoma: Urothelial carcinoma
Final Diagnosis
Bladder transitional cell carcinoma
Stage/Grade
pT2 / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal

Patient
Sex
Female
Age (at time of tissue collection)
78
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BL0479F1895P0002P1 from passage P1 has a TMB score of 12.92
Sample BL0479F1895P0005P1 from passage P1 has a TMB score of 12.92
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BL0479F1895P0002P1 from passage P1     Score:MSI-S
Sample:BL0479F1895P0005P1 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

Patient tumor for PDX model TM00026.
P0 tumor for PDX model TM00026.

Dosing Studies

 no data

Circos Plots

Circos plot