PDX Model DetailsTM00058

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00058 (BN218F)
Initial Diagnosis
Brain glioblastoma multiforme
Final Diagnosis
Adult glioblastoma multiforme
Stage/Grade
Not Specified /
Primary Site
Brain
Sample Site
Brain
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
52
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample SN0218F006P0002P1 from passage P1 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:SN0218F006P0002P1 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P1, P2 pathology consistent with glioblastoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis. P2 pathology done by Dr. Dorina Gui, University of California, Davis.P2 pathology for model F006 ID11 consistent with gliobastoma multiforme.

P0 tumor for PDX model TM00058.

P0 tumor for PDX model TM00058 ; GFAP marker

P1 tumor F006 for PDX model TM00058 stained for H&E.

P1 tumor F006 for PDX model TM00058 stained for AE1AE3. Staining was negative.

P1 tumor F006 for PDX model TM00058 stained for CD45. Staining was negative.

P1 tumor F006 for PDX model TM00058 stained for Ki67. Staining was positive.

P1 tumor F006 for PDX model TM00058 stained for GFAP. Staining was positive.

P2 tumor F006 ID013 for PDX model J000106533 stained for H&E.

P2 tumor F006 ID11 for PDX model TM00058 stained for H&E.

P2 tumor F006 ID013 for PDX model J000106533 stained for AE1AE3. Staining was negative.

P2 tumor F006 ID11 for PDX model TM00058 stained for AE1/AE3. Staining was negative.

P2 tumor F006 ID013 for PDX model J000106533 stained for CD45. Staining was negative.

P2 tumor F006 ID013 for PDX model J000106533 stained for GFAP. Staining was Positive.

P2 tumor F006 ID11 for PDX model TM00058 stained for GFAP. Staining was negative.

P2 tumor F006 ID013 for PDX model J000106533 stained for Ki67. Staining was Positive.

P2 tumor F006 ID11 for PDX model TM00058 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots


Circos plot for P0 tumor #002 for PDX model TM00058 (aka, BN218F)

Circos plot for P0 tumor #006 for PDX model TM00058 (aka, BN218F)