PDX Model DetailsTM00091

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00091 (BR0901F)
Initial Diagnosis
invasive ductal carcinoma
Final Diagnosis
invasive ductal carcinoma
Stage/Grade
AJCC IIB / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
45
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Samples
Sample from passage P0 has a TMB score of 4.85
Sample from passage P3 has a TMB score of 7.27
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:BR0901F433P3     Score:MSI-S
Sample:BR0901F433P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P1, P4 pathology consistent with breast carcinoma. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F433 P0014 for PDX model TM00091 stained for AR. Staining was negative.

P1 tumor F433 P0014 for PDX model TM00091 stained for ER. Staining was negative.

P1 tumor F433 P0014 for PDX model TM00091 stained for ERBB2 (HER2). Staining was negative.

P1 tumor F433 P0014 for PDX model TM00091 stained for PR. Staining was negative.

P2 tumor F433 ID013 for PDX model TM00091 stained for H&E.

P2 tumor F433 ID013 for PDX model TM00091 stained for AE1AE3. Staining was positive.

P2 tumor F433 ID013 for PDX model TM00091 stained for AR. Staining was negative.

P2 tumor F433 ID013 for PDX model TM00091 stained for CD45. Staining was negative.

P2 tumor F433 ID013 for PDX model TM00091 stained for ER(SP1). Staining was negative.

P2 tumor F433 ID013 for PDX model TM00091 stained for ERBB2 (HER2). Staining was negative.v

P2 tumor F433 ID013 for PDX model TM00091 stained for Ki67. Staining was positive.

P2 tumor F433 ID013 for PDX model TM00091 stained for PR. Staining was negative.

P4 tumor F433 ID001 for PDX model TM00091 stained for H&E.

P4 tumor F433 ID001 for PDX model TM00091 stained for AE1AE3. Staining was positive.

P4 tumor F433 ID001 for PDX model TM00091 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots


Circos plot for P0 tumor #433 from PDX model TM00091 (aka, BR0901F)