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Last Database Update
2020-03-29
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00099 Previous ID:BR1367F
Primary Site:Breast Initial Diagnosis:invasive ductal carcinoma Final Diagnosis:invasive ductal carcinoma
Tumor Site:Breast Tumor Type:Primary Malignancy Stage / Grade:AJCC IIA / Grade:3
Patient
Sex:Female Age:44 Race / Ethnicity:Asian or Pacific Islander / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 3.23
Sample from passage P6 has a TMB score of 5.66
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:BR1367F003P6     Score:MSI-S
Sample:BR1367F033P0     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hg10st, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology:

Patient tumor for PDX model TM00099.

Patient tumor for PDX model TM00099; PR marker (negative)

Patient tumor for PDX model TM00099; ER marker (negative)

P0 tumor #033 for PDX model TM00099.

P0 tumor #033 for PDX model TM00099; PR marker (negative)

P0 tumor #033 for PDX model TM00099; ER marker (negative)

P0 tumor #033 for PDX model TM00099; HER2 (ERBB2) marker (negative)
Circos Plots:

Circos plot for P0 tumor #033 from PDX model TM00099
Dosing Studies: