PDX Model DetailsTM00099

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00099 (BR1367F)
Initial Diagnosis
invasive ductal carcinoma
Final Diagnosis
invasive ductal carcinoma
Stage/Grade
AJCC IIA / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
44
Race/Ethnicity
Asian or Pacific Islander / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Samples
Sample from passage P0 has a TMB score of 5.66
Sample from passage P6 has a TMB score of 4.85
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:BR1367F003P6     Score:MSI-S
Sample:BR1367F033P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology


Patient tumor for PDX model TM00099.

Patient tumor for PDX model TM00099; PR marker (negative)

Patient tumor for PDX model TM00099; ER marker (negative)

P0 tumor #033 for PDX model TM00099.

P0 tumor #033 for PDX model TM00099; PR marker (negative)

P0 tumor #033 for PDX model TM00099; ER marker (negative)

P0 tumor #033 for PDX model TM00099; HER2 (ERBB2) marker (negative)

Dosing Studies

Circos Plots


Circos plot for P0 tumor #033 from PDX model TM00099