PDX Model DetailsTM00103

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00103 (BR0869F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC 1 / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
73
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BR0869F000P0000P1 from passage P1 has a TMB score of 8.08
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BR0869F000P0000P1 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor ID172 for PDX model TM00103. Infiltrating ductal carcinoma with extensive necrosis, MBR Grade 3.
P1 tumor ID172 for PDX model TM00103 stained for ER. No staining was detected.

P1 tumor ID172 for PDX model TM00103 stained for HER-2. No staining was detected.
P1 tumor ID172 for PDX model TM00103 stained for KI67. Staining was positive.

P1 tumor ID172 for PDX model TM00103 stained for PR. No staining was detected.
P1 tumor ID172 for PDX model TM00103 stained for VIMENTIN. Diffuse positive cytoplasmic staining, consistent with EMT transformation.

Dosing Studies

Circos Plots

 no data