PDX Model DetailsTM00107

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00107 (BR1936F) Initial Diagnosis Breast carcinoma Final Diagnosis Invasive ductal carcinoma Stage/Grade AJCC IV / Grade:3 Primary Site Breast Sample Site Breast Tumor Type Recurrent/Relapse
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Female Age (at time of tissue collection) 48 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker No / No
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hu133, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample BR1936F227P0 from passage P0 has a TMB score of 5.66 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:BR1936F227P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Tumor Markers:
The hormone receptor status for PDX model TM00107 is ER-/PR-/HER2-. Note that the clinical information provided to JAX reports that the patient is ER+ (weakly)/PR-/HER2-. Patient tumor reported as ER positive (weakly)/PR positive/ERBB2 negative.
Summary:
P0, P1 pathology consistent with triple negative breast carcinoma. P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00107 stained for H&E.	P0 tumor F227 for PDX model TM00107 stained for H&E.
P1 tumor F224 ID010 for PDX model TM00107 stained for H&E.	P1 tumor F224 ID010 for PDX model TM00107 stained for AE1AE3. Staining was positive.
P1 tumor F224 ID010 for PDX model TM00107 stained for CD45. Staining was negative.	P1 tumor F224 ID010 for PDX model TM00107 stained for ER. Staining was negative.
P1 tumor F224 ID010 for PDX model TM00107 stained for PR. Staining was negative.	P1 tumor F224 ID010 for PDX model TM00107 stained for ERBB2 (HER2). Staining was negative.
P1 tumor F224 ID015 for PDX model TM00107 stained for H&E.	P1 tumor F224 ID015 for PDX model TM00107 stained for AE1AE3. Staining was positive.
P1 tumor F224 ID015 for PDX model TM00107 stained for CD45. Staining was negative.	P1 tumor F224 ID015 for PDX model TM00107 stained for Ki67. Staining was positive.