PDX Model DetailsTM00165

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00165 (CN0446F) Initial Diagnosis Adenocarcinoma Final Diagnosis Adenocarcinoma Stage/Grade AJCC IV / Primary Site Anal Sample Site Liver Tumor Type Metastatic
Patient	Sex Male Age (at time of tissue collection) 78 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker No / Yes
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Core needle biopsy Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hg10st, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	no data
Microsatellite Instability	no data
Gene Fusion	no data

Model Characterization

Histology

Summary:
P1 pathology consistent with adenocarcinoma. P2 pathology consistent with poorly differentiated mucinous adenocarcinoma with "signet ring" pattern. P2 ID033 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00165.	Patient tumor for PDX model TM00165; HER2 (ERBB2) marker
P0 tumor #447 for PDX model TM00165.	P0 tumor #447 for PDX model TM00165; HER2 (ERBB2) marker
P0 tumor #448 for PDX model TM00165.	P1 tumor F447 ID019 for PDX model TM00165 stained for H&E.
P1 tumor F447 ID019 for PDX model TM00165 stained for AE1AE3. Staining was positive.	P1 tumor F447 ID019 for PDX model TM00165 stained for CD45. Staining was negative.
P1 tumor F447 ID019 for PDX model TM00165 stained for Ki67. Staining was positive.	P2 tumor F447 for PDX model TM00165 stained for H&E.
P2 tumor F447 ID033 for PDX model TM00165 stained for H&E.	P2 tumor F447 for PDX model TM00165 stained for AE1AE3. Staining was positive.
P2 tumor F447 ID033 for PDX model TM00165 stained for AE1AE3. Staining was positive.	P2 tumor F447 for PDX model TM00165 stained for CD45. Staining was negative.
P2 tumor F447 ID033 for PDX model TM00165 stained for CD45. Staining was negative.