PDX Model DetailsTM00170

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00170 (CN1572F) Initial Diagnosis Adenocarcinoma Final Diagnosis Adenocarcinoma Stage/Grade AJCC IV / Primary Site Colon Sample Site Liver Tumor Type Metastatic
Patient	Sex Male Age (at time of tissue collection) 30 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hu133, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample CN1572F2026P0 from passage P0 has a TMB score of 2.43 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:CN1572F2026P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
P0, P2 pathology consistent with colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F2026 for PDX model TM00170 stained for H&E.	P2 tumor F2026 ID001 for PDX model TM00170 stained for H&E.
P2 tumor F2026 ID001 for PDX model TM00170 stained for AE1AE3. Staining was positive.	P2 tumor F2026 ID001 for PDX model TM00170 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

no data