PDX Model DetailsTM00176

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00176 (PA0165F)
Initial Diagnosis
Pancreatic carcinoma
Final Diagnosis
Pancreatic carcinoma
Stage/Grade
AJCC IV /
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Metastatic

Patient
Sex
Male
Age (at time of tissue collection)
77
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample PA0165F629P0000P1011P2 from passage P2 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:PA0165F629P0000P1011P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1 pathology consistent with pancreatic carcinoma. P2 Pathology consistent with a pancreatic ductal carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00176 stained for H&E.
P0 tumor #629 for PDX model TM00176 stained for H&E.

P0 tumor F629 for PDX model TM00176 stained for H&E.
P0 tumor F629 for PDX model TM00176 stained for vimentin. Staining was positive.

P1 tumor F629 ID015 for PDX model TM00176 stained for H&E.
P1 tumor F629 ID015 for PDX model TM00176 stained for AE1AE3. Staining was positive.

P1 tumor F629 ID015 for PDX model TM00176 stained for CD45. Staining was negative.
P2 tumor F629 ID011 for PDX model TM00176 stained for H&E.

P2 tumor F629 ID011 for PDX model TM00176 stained for AE1AE3. Staining was positive.
P2 tumor F629 ID011 for PDX model TM00176 stained for CD45. Staining was negative.

P2 tumor F629 ID011 for PDX model TM00176 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data