PDX Model DetailsTM00192

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00192 (LG0567F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IB / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
57
Race/Ethnicity
Asian or Pacific Islander / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Yes / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0567F669P0 from passage P0 has a TMB score of 6.46
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0567F669P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00192. Large irregular glands of markedly pleomorphic cells including giant nuclei and mitotic figures.
P0 tumor #671 for PDX model TM00192. Large irregular glands of markedly pleomorphic cells including giant and multiple nuclei.

P2 tumor #671 for PDX model TM00192 stained for H&E. This is a poorly differentiated adenocarcinoma.
P2 tumor #671 for PDX model TM00192 immunostained for AE1/AE3. Staining is positive. This is a poorly differentiated adenocarcinoma.

P2 tumor F671 ID013 for PDX model TM00192 stained for AE1/AE3. Staining was positive.
P2 tumor #671 for PDX model TM00192 immunostained for CD45. Staining is negative. This is a poorly differentiated adenocarcinoma.

P2 tumor F671 ID013 for PDX model TM00192 stained for CD45. Staining was negative.
P2 tumor #671 for PDX model TM00192 immunostained for Ki67. Staining is positive. This is a poorly differentiated adenocarcinoma.

P2 tumor F671 ID013 for PDX model TM00192 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data