PDX Model DetailsTM00194

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00194 (LG0627PE)
Initial Diagnosis
Lung small cell carcinoma
Final Diagnosis
Lung small cell carcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Pleural cavity
Tumor Type
Metastatic

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
60
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Pleural effusion
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG0627PE569P0000P1030P2 from passage P2 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG0627PE569P0000P1030P2 from passage P2     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
PE (pleural effusion) is believed to be from P0 but this has not been confirmed. PE, P2 pathology consistent with small cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Primary tumor for PDX model TM00194 stained for H&E.

PE tumor F596 PE ID962 for PDX model TM00194 stained for H&E.

P2 tumor PEF596 ID014 for PDX model TM00194 stained for H&E.

P2 tumor PEF596 ID014 for PDX model TM00194 stained for AE1AE3. Staining was positive.

P2 tumor PEF596 ID014 for PDX model TM00194 stained for CD45. Staining was negative.

P2 tumor PEF596 ID014 for PDX model TM00194 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data