PDX Model DetailsTM00213

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00213 (LG0997F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC II / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586
Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R

Patient
Sex
Male
Age (at time of tissue collection)
70
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0997F1574P0 from passage P0 has a TMB score of 16.96
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0997F1574P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model TM00213.
P0 tumor #1574 for PDX model TM00213.

P2 tumor LG-997 ID014 for PDX model TM00213 stained for H&E.
P2 tumor LG-997 ID014 for PDX model TM00213 stained for AE1AE3. Staining was positive.

P2 tumor LG-997 ID014 for PDX model TM00213 stained for CD45. Staining was negative.
P2 tumor LG-997 ID014 for PDX model TM00213 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data