PDX Model DetailsTM00214

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00214 (LG1011PE)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IIIB /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
51
Race/Ethnicity
Asian or Pacific Islander / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Pleural effusion
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

Sample LG1011PE1607P0000P1004P2 from passage P2 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG1011PE1607P0000P1004P2 from passage P2     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology


Patient tumor for PDX model TM00214.

P0 tumor #1607 for PDX model TM00214.

Dosing Studies

Circos Plots

no data