PDX Model DetailsTM00253

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00253 (LG1260F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Lung
Sample Site
Adrenal gland
Tumor Type
Metastatic

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Male
Age (at time of tissue collection)
66
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG1260F097P0 from passage P0 has a TMB score of 8.89
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG1260F097P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 and P1 tumor Pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F098 for PDX model TM00253 stained for H&E.

P0 tumor F098 for PDX model TM00253 stained for AE1AE3. Staining was positive.

P0 tumor F098 for PDX model TM00253 stained for CD45. Staining was negative.

P0 tumor F098 for PDX model TM00253 stained for Ki67. Staining was positive.

P1 tumor F098 ID023 for PDX model TM00253 stained for H&E.

P1 tumor F098 ID023 for PDX model TM00253 stained for AE1AE3. Staining was positive

P1 tumor F098 ID023 for PDX model TM00253 stained for CD45. Staining was negative

P1 tumor F098 ID023 for PDX model TM00253 stained for Ki67. Staining was positive

Dosing Studies

Circos Plots

no data