PDX Model DetailsTM00302

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00302 (LG1306aF)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Kidney
Tumor Type
Metastatic

Related Models

PDX models TM00222 and TM00302 originated from the same patient.

Publications citing this model

Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
53
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG1306F130P0078P1 from passage P1 has a TMB score of 8.08
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG1306F130P0078P1 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 pathology consistent with adenocarcinoma. P3 pathology consistent with carcinoma but has lost adenocarcinoma differentiation.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P0 tumor #130 for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 4x image.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 20x image.

P3 tumor F130 ID16 from model TM00302 stained for AE1AE3.

Dosing Studies

Circos Plots

no data