PDX Model DetailsTM00327

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00327 (OV12JX01F)
Initial Diagnosis
ovary serous adenocarcinoma
Final Diagnosis
ovary papillary carcinoma
Stage/Grade
AJCC IIIC / Grade:high
Primary Site
Ovary
Sample Site
Omentum
Tumor Type
Metastatic

Patient

Sex
Female
Age (at time of tissue collection)
50
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

no data

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:OV12JX01F017P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 and P2 pathology consistent with high grade ovarian carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F021 for PDX model TM00327 stained for H&E.

P0 tumor F021 for PDX model TM00327 stained for CD45. Staining was negative.

P0 tumor F021 for PDX model TM00327 stained for Ki67. Staining was positive.

P2 tumor F022 ID007for PDX model TM00327 stained for H&E.

P0 tumor F022 ID007 for PDX model TM00327 stained for CD45. Staining was negative.

P0 tumor F022 ID007 for PDX model TM00327 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots

no data