PDX Model DetailsTM00332

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00332 (OV0529F)
Initial Diagnosis
Ovarian serous carcinoma
Final Diagnosis
Ovarian serous carcinoma
Stage/Grade
AJCC IIIC /
Primary Site
Ovary
Sample Site
Ovary
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
56
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample OV0529F1939P0 from passage P0 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:OV0529F1939P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2 pathology consistent with undifferentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P2 tumor F19400 ID012 for PDX model TM00332 stained for H&E.
P2 tumor F19400 ID012 for PDX model TM00332 stained for AE1/AE3. Staining was positive.

P2 tumor F19400 ID012 for PDX model TM00332 stained for CD45. Staining was negative.
P2 tumor F19400 ID012 for PDX model TM00332 stained for Ki67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data