PDX Model DetailsTM00381

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00381 (SA00209F)
Initial Diagnosis
Spindle cell sarcoma
Final Diagnosis
Spindle cell sarcoma
Stage/Grade
AJCC IB / Grade:3
Primary Site
Soft tissue
Sample Site
Soft tissue
Tumor Type
Primary Malignancy

Publications citing this model

 Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R

Patient
Sex
Female
Age (at time of tissue collection)
62
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Sheets of pleomorphic spindle cells with scattered multinucleated cells.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00381.
P0 tumor #15 for PDX model TM00381.

P1 tumor #12_000 for PDX model TM00381.

Dosing Studies

 no data

Circos Plots

 no data