PDX Model DetailsTM00386

Request information on the availability of this model.

PDX Model Summary
Model Details	Model ID (Previous ID) TM00386 (BR0555F) Initial Diagnosis Invasive ductal carcinoma Final Diagnosis Invasive ductal carcinoma Stage/Grade AJCC IV / Grade:2 Primary Site Breast Sample Site Breast Tumor Type Primary Malignancy
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Female Age (at time of tissue collection) 86 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker No / No
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hg10st, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample BR0555F294P0 from passage P0 has a TMB score of 5.66 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:BR0555F294P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Tumor Markers:
Patient is ER positive; PR positive; HER2 (ERRB2) negative. P0 and P1 tumors reflect the marker status of the patient tumor. P4 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00386.	Patient tumor for PDX model TM00386; PR marker (positive)
Patient tumor for PDX model TM00386; ER marker (positive)	P0 tumor #294 for PDX model TM00386.
P0 tumor #294 for PDX model TM00386; PR marker (positive)	P0 tumor #294 for PDX model TM00386; ER marker (positive)
P1 tumor #294 for PDX model TM00386.	P1 tumor #294 for PDX model TM00386.
P1 tumor #294 for PDX model TM00386; PR marker (positive)	P1 tumor #294 for PDX model TM00386; ER marker (positive)
P4 tumor F294 ID023 for PDX model TM00386 stained for H&E.	P4 tumor F294 ID023 for PDX model TM00386 stained for AE1/AE3. Staining was positive.
P4 tumor F294 ID023 for PDX model TM00386 stained for CD45. Staining was positive.	P4 tumor F294 ID023 for PDX model TM00386 stained for Ki67. Staining was positive.
P4 tumor F294 ID023 for PDX model TM00386 stained for AR. Staining was negative.	P4 tumor F294 ID023 for PDX model TM00386 stained for ER. Staining was positive.
P4 tumor F294 ID023 for PDX model TM00386 stained for ERBB2 (HER2). Staining was negative.	P4 tumor F294 ID023 for PDX model TM00386 stained for PR. Staining was negative.
P5 tumor F294 ID029 for PDX model TM00386 stained for H&E.	P5 tumor F294 ID029 for PDX model TM00386 stained for AE1/AE3.
P5 tumor F294 ID029 for PDX model TM00386 stained for CD45.	P5 tumor F294 ID029 for PDX model TM00386 stained for Ki67.
P5 tumor F294 ID029 for PDX model TM00386 stained for AR.	P5 tumor F294 ID029 for PDX model TM00386 stained for ER.
P5 tumor F294 ID029 for PDX model TM00386 stained for ERBB2 (HER2).	P5 tumor F294 ID029 for PDX model TM00386 stained for PR.