PDX Model DetailsTM00916

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00916 (OM1058F)
Initial Diagnosis
ovary serous adenocarcinoma
Final Diagnosis
ovary serous adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Ovary
Sample Site
Omentum
Tumor Type
Metastatic

Related Models

PDX models TM00916, TM00913 and TM00914 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 4.04
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:OM1058F141P059P1     Score:MSI-S

Gene Fusion

Fusion Genes
Sample OM1058F141P0 has fusion gene RAD51AP1 - DYRK4

Model Characterization

Histology

Summary:
P0, P1, P2 pathology consistent with serous carcinoma of ovary.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F141 for PDX model TM00916 stained for H&E.

P0 tumor F141 for PDX model TM00916 stained for AE1AE3. Staining was positive

P0 tumor F141 for PDX model TM00916 stained for CD45. Staining was negative.

P1 tumor F141 for PDX model TM00916 stained for H&E.

P2 tumor F142 ID007 for PDX model TM00916 stained for H&E.

Dosing Studies

no data

Circos Plots

no data