PDX Model DetailsJ000079689

This PDX model is not available. (No inventory)

PDX Model Summary

Model Details
Model ID
J000079689
Initial Diagnosis
Neuroblastoma
Final Diagnosis
Neuroblastoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Retroperitoneum
Sample Site
Lymph node
Tumor Type
Metastatic

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
5
Race/Ethnicity
Black / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample J000095142 from passage P0 has a TMB score of 4.85
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000095142 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Pathology consisitent with neuroblastoma with fidelity to P1.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor for PDX model J000079689 stained for H&E.
P0 tumor for PDX model J000079689 stained for vimentin. Staining was negative.

P1 tumor F001 ID007 for PDX model J000079689 stained for H&E.
P1 tumor F001 ID007 for PDX model J000079689 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data