PDX Model DetailsJ000092712

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PDX Model Summary

Model Details
Model ID
J000092712
Initial Diagnosis
Urinary bladder cancer
Final Diagnosis
Bladder transitional cell carcinoma
Stage/Grade
AJCC III / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Patient
Sex
Male
Age (at time of tissue collection)
57
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000095175 from passage P0 has a TMB score of 11.31
Sample J000096798 from passage P0 has a TMB score of 13.73
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000095175 from passage P0     Score:MSI-S
Sample:J000096798 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1 pathology consistent with urothelial carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

PT tumor for PDX model J000092712 (aka, BL-757) stained for H&E.
P0 tumor F004 for PDX model J000092712 stained for H&E.

P0 tumor F004 for PDX model J000092712 stained for vimentin. Staining was negative.
P1 tumor F004 ID008 for PDX model J000092712 stained for H&E.

P1 tumor F004 ID008 for PDX model J000092712 stained for AE1AE3. Staining was positive.
P1 tumor F004 ID008 for PDX model J000092712 stained for CD45. Staining was negative.

Dosing Studies

 no data

Circos Plots

 no data