PDX Model DetailsJ000096652

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PDX Model Summary

Model Details

Model ID
J000096652
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IIIB / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
55
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Yes / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000099828 from passage P0 has a TMB score of 24.23
Sample J000099831 from passage P0 has a TMB score of 25.84
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000099828 from passage P0     Score:MSI-S
Sample:J000099831 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with high grade carcinoma. 4x and 20x primary tumor images were given diagnosis of Squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor (PT) for PDX model J000096652 stained for H&E.

Patient tumor for PDX model J000096652 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000096652 stained for H&E. This is a 20x image

P0 tumor F001 for PDX model J000096652 stained for H&E.

P1 tumor ID007 for PDX model J000096652 stained for H&E.

Dosing Studies

Circos Plots

no data