PDX Model DetailsJ000099327

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PDX Model Summary

Model Details

Model ID
J000099327
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Recurrent/Relapse

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
70
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000100857 from passage P0 has a TMB score of 6.46
Sample J000101348 from passage P0 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000100857 from passage P0     Score:MSI-S
Sample:J000101348 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1, P2 and P3 pathology consistent with high grade breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000099327 stained with H&E.

Patient tumor for PDX model J000099327 immunostained for ER. Staining was negative.

Patient tumor for PDX model J000099327 immunostained for ERBB2 (HER2). Staining was negative.

Patient tumor for PDX model J000099327 immunostained for PR. Staining was negative.

Patient tumor for PDX model J000099327 immunostained for Ki67. Staining was positive.

Patient tumor for PDX model J000099327 immunostained for Vimentin. Staining was positive in the stroma.

P0 tumor F001 for PDX model J000099327 stained for H&E.

P0 tumor F001 for PDX model J000099327 immunostained for Ki67. Staining was positive.

P1 tumor F001 ID011 for PDX model J000099327 stained for H&E.

P1 tumor F001 ID011 for PDX model J000099327 immunostained for Ki67. Staining was positive.

P2 tumor F001 ID001 for PDX model J000099327 stained for H&E.

P2 tumor F001 ID001 for PDX model J000099327 immunostained for Ki67. Staining was positive.

P2 tumor F001 ID001 for PDX model J000099327 immunostained for Ae1Ae3. Staining was positive.

P2 tumor F001 ID001 for PDX model J000099327 immunostained for CD45. Staining was negative.

P3 tumor F001 ID011 for PDX model J000099327 stained for H&E.

P3 tumor F001 ID011 for PDX model J000099327 immunostained for Ki67. Staining was positive.

P3 tumor F001 ID003 for PDX model J000099327 stained for H&E.

P3 tumor F001 ID003 for PDX model J000099327 immunostained for ER. Staining was negative.

P3 tumor F001 ID003 for PDX model J000099327 immunostained for ERBB2 (HER2). Staining was negative.

P3 tumor F001 ID003 for PDX model J000099327 immunostained for PR. Staining was negative.

Dosing Studies

Circos Plots

no data