PDX Model DetailsJ000100672

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PDX Model Summary

Model Details

Model ID
J000100672
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Pleural cavity
Tumor Type
Metastatic

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Male
Age (at time of tissue collection)
50
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Pleural effusion
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000102690 from passage P0 has a TMB score of 11.31
Sample J000103864 from passage P1 has a TMB score of 11.31
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000102690 from passage P0     Score:MSI-S
Sample:J000103864 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
Squamous cell carcinoma with high fidelity through P3. P2 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000100672 stained with H&E.

P2 tumor F001 ID014 for PDX model J000100672 stained for H&E.

P2 tumor F001 ID014 for PDX model J000100672 stained for H&E.

P2 tumor F001 ID014 for PDX model J000100672 stained for AE1AE3. Staining was positive.

P2 tumor F001 ID014 for PDX model J000100672 stained for CD45. Staining was negative.

P2 tumor F001 ID014 for PDX model J000100672 stained for Ki67. Staining was positive.

P3 tumor F001 ID04 for PDX model J000100672 stained for H&E.

Dosing Studies

Circos Plots

no data