PDX Model DetailsJ000100674

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PDX Model Summary

Model Details

Model ID
J000100674
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IIIC / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
61
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000101830 from passage P0 has a TMB score of 3.23
Sample J000101974 from passage P0 has a TMB score of 4.04
Sample J000103088 from passage P1 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000101830 from passage P0     Score:MSI-S
Sample:J000101974 from passage P0     Score:MSI-S
Sample:J000103088 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
No patient tumor images available. P1 pathology consistent with invasive ductal carcinoma. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor #001_006 for PDX model J1000100674. Sheets of moderately pleomorphic carcinoma cells.

P1 tumor #001_006 for PDX model J000100674. Negative for ER staining.

P1 tumor #001_006 for PDX model J000100674. Negative for ERBB2 (aka, HER2) staining.

P1 tumor #001_006 for PDX model J000100674. Negative for PR staining.

P1 tumor #001_006 for PDX model J000100674. Positive for human ki67 staining indicating the presence of human tumor cells.

P2 tumor F002 ID002 for PDX model J000100674 stained for H&E.

P2 tumor F002 ID002 for PDX model J000100674 stained for AE1AE3. Staining was positive.

P2 tumor F002 ID002 for PDX model J000100674 stained for AR. Staining was negative.

P2 tumor F002 ID002 for PDX model J000100674 stained for CD45. Staining was negative.

P2 tumor F002 ID002 for PDX model J000100674 stained for ER. Staining was negative.

P2 tumor F002 ID002 for PDX model J000100674 stained for ERBB2 (HER2). Staining was negative.

P2 tumor F002 ID002 for PDX model J000100674 stained for PR. Staining was negative.

P2 tumor F002 ID002 for PDX model J000100674 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data