PDX Model DetailsJ000101173

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PDX Model Summary

Model Details
Model ID
J000101173
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC II / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Related Models

 PDX models J000101173 and J000103634 originated from the same patient.

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
55
Race/Ethnicity
White / Hispanic
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000103532 from passage P0 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000103532 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1, P2 pathology consistent with carcinoma with moderate fidelity to PT.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

PT tumor for PDX model J000101173 stained for H&E.
P0 tumor ID002 for PDX model J000101173 stained for H&E.

P1 tumor ID016 for PDX model J000101173 stained for H&E.
P1 tumor ID016 for PDX model J000101173 stained for ER. Staining was negative.

P1 tumor ID016 for PDX model J000101173 stained for ERBB2 (HER2). Staining was negative.
P1 tumor ID016 for PDX model J000101173 stained for PR. Staining was negative.

P2 tumor ID021 for PDX model J000101173 stained for H&E.

Dosing Studies

Circos Plots

 no data