PDX Model DetailsJ000101329

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PDX Model Summary

Model Details

Model ID
J000101329
Initial Diagnosis
Adenocarcinoma
Final Diagnosis
Adenocarcinoma
Stage/Grade
IV /
Primary Site
Colon
Sample Site
Lymph node
Tumor Type
Metastatic

Related Models

PDX models J000101328 and J000101329 originated from the same patient.

Patient

Sex
Male
Age (at time of tissue collection)
72
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000102066 from passage P0 has a TMB score of 47.64
Sample J000103067 from passage P1 has a TMB score of 49.26
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000102066 from passage P0     Score:MSI-H
Sample:J000103067 from passage P1     Score:MSI-H

Gene Fusion

no data

Model Characterization

Histology

Summary:
Metastatic undifferentiated carcinoma of colonic origin. This model is from the same patient as J000101328.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000101329 stained for H&E.

P0 tumor for PDX model J000101329 stained for H&E.

P0 tumor F001 for PDX model J000101329 stained for vimentin. Staining was positive.

P1 tumor ID007 for PDX model J000101329 stained for H&E.

Dosing Studies

Circos Plots

no data