PDX Model DetailsJ000101866

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PDX Model Summary

Model Details
Model ID
J000101866
Initial Diagnosis
Osteosarcoma
Final Diagnosis
Osteosarcoma
Stage/Grade
III / Grade:High
Primary Site
Bone
Sample Site
Bone
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
18
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample J000104662 from passage P1 has a TMB score of 4.85
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000104662 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
PT and P1 pathology consistent with spindle cell sarcoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model J000101866 stained for H&E.
P1 tumor ID006 for PDX model J000101866 stained for H&E.

P1 tumor ID006 for PDX model J000101866 stained for AE1AE3. Staining was negative.
P1 tumor ID006 for PDX model J000101866 stained for Ki67. Staining was positive.

P1 tumor ID006 for PDX model J000101866 stained for CD45. Staining was negative.

Dosing Studies

 no data

Circos Plots

 no data