PDX Model DetailsJ000102630

PDX Model Summary
Model Details	Model ID J000102630 Initial Diagnosis Colon adenocarcinoma Final Diagnosis Colon adenocarcinoma Stage/Grade AJCC IV / Grade:III Primary Site Colon Sample Site Liver Tumor Type Metastatic
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Male Age (at time of tissue collection) 37 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Core needle biopsy Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample J000106822 from passage P1 has a TMB score of 13.73 Sample J000107525 from passage P2 has a TMB score of 11.31 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:J000106822 from passage P1 Score:MSI-S Sample:J000107525 from passage P2 Score:MSI-S
Gene Fusion	no data

Model Characterization

Summary:
P2 pathology consistent with colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Primary tumor for PDX model J000102630 stained for H&E.

P2 tumor F002 ID002 for PDX model J000102630 stained for H&E.

no data