PDX Model DetailsJ000102680

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PDX Model Summary

Model Details
Model ID
J000102680
Initial Diagnosis
Colon adenocarcinoma
Final Diagnosis
Colon adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Colon
Sample Site
Liver
Tumor Type
Metastatic

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
36
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000107098 from passage P1 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000107098 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 Pathology consistent with carcinoma. No features of adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F002 ID023 for PDX model J000102680 stained for H&E.
P1 tumor F002 ID023 for PDX model J000102680 stained for AE1AE3. Staining was positive.

P1 tumor F002 ID023 for PDX model J000102680 stained for CD45. Staining was negative.
P1 tumor F002 ID023 for PDX model J000102680 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data